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ClinicalTrials.gov 135 recruiting now official registry

Parkinson Disease clinical trials

135 of 298 indexed Parkinson Disease trials are currently recruiting.

298 US clinical trials · 135 currently recruiting

Parkinson Disease is the subject of 298 registered US clinical trials on ClinicalTrials.gov, 135 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 66 in Phase 1-2 (earlier-stage). The most active sponsor is University of Minnesota, running 10 of these trials.

The research picture

Parkinson Disease has 298 registered US clinical trials, 135 of them open to new participants right now, about 45% of the total.

135
recruiting participants now
45%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
10
top sponsor: University of Minnesota
Phase 131Phase 235Phase 38Phase 413

Active & Recent Trials

298 total, page 5 of 6

COMPLETED Phase 2 129 participants

Open-label, Long-term Safety Extension Study of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias

Novartis Pharmaceuticals

NCT01491932

COMPLETED NA 128 participants

Study in Parkinson's Disease of Exercise

University of Colorado, Denver

NCT01506479

COMPLETED NA 120 participants

Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

National Institute of Mental Health (NIMH)

NCT00004451

COMPLETED 114 participants

Fox BioNet Project: LRRK2-002

Michael J. Fox Foundation for Parkinson's Research

NCT03545425

COMPLETED NA 112 participants

Driving Performance of People With Parkinson's Using Autonomous In-Vehicle Technologies

University of Florida

NCT04660500

COMPLETED Phase 1 110 participants

A Study to Investigate a New Treatment in Patients With Parkinson's Disease

Tools4Patient

NCT03407378

COMPLETED NA 108 participants

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

University of Alabama at Birmingham

NCT03797378

COMPLETED NA 104 participants

Effects of Aerobic Exercise in Parkinson's Disease

US Department of Veterans Affairs

NCT00784563

COMPLETED 97 participants

The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease

Boston University Charles River Campus

NCT06483126

COMPLETED Phase 2 94 participants

GM1 Ganglioside Effects on Parkinson's Disease

Thomas Jefferson University

NCT00037830

COMPLETED 89 participants

Biomarkers of Risk of Parkinson Disease

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00775853

COMPLETED Phase 1 82 participants

Quantitative Mapping of Substantia Nigra Iron in Parkinson's Disease (Stages I-IV, REM Sleep Behavior Disorder) and Controls

Weill Medical College of Cornell University

NCT03675282

COMPLETED 81 participants

PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

Indiana University

NCT01536821

COMPLETED 80 participants

Transcranial Magnetic Stimulation in Parkinson's Disease

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00023062

COMPLETED Phase 2 79 participants

A Study to Assess the Safety of GRF6021 Infusions in Subjects With Parkinson's Disease and Cognitive Impairment

Alkahest

NCT03713957

COMPLETED Phase 3 77 participants

Behavioral or Solifenacin Therapy for Urinary Symptoms in Parkinson Disease

VA Office of Research and Development

NCT03149809

COMPLETED 72 participants

GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology

ConvaTec

NCT05470751

COMPLETED NA 72 participants

Visual Spatial Exploration and Art Therapy Intervention in Patients Diagnosed With Parkinson's Disease

NYU Langone Health

NCT03178786

COMPLETED Phase 2 64 participants

A Study of TAK-071 in People With Parkinson Disease

Takeda

NCT04334317

COMPLETED 63 participants

Brain Networks and Consciousness

University of Texas Southwestern Medical Center

NCT04502550

COMPLETED Phase 2 62 participants

PD4PD:Partnered Dance for Parkinson Disease

Washington University School of Medicine

NCT01388556

COMPLETED Phase 2 62 participants

Imaging and Genetic Biomarkers of Parkinson Disease (PD) Onset and Progression in High-risk Families

Institute for Neurodegenerative Disorders

NCT00273351

COMPLETED Phase 1 60 participants

Safety and Tolerability Study of K0706 in Subjects With Parkinson's Disease

Sun Pharma Advanced Research Company Limited

NCT02970019

COMPLETED Phase 2 60 participants

Clinical Trial for Parkinson's Disease Using Allogeneic HB-adMSCs (Early and Moderate PD)

Hope Biosciences Research Foundation

NCT04995081

COMPLETED 58 participants

Speech, Linguistic and Acoustic Markers in Parkinson's Disease

University of Massachusetts, Worcester

NCT04273672

COMPLETED Phase 1 57 participants

Lu AF28996 in Participants With Parkinson's Disease (PD)

H. Lundbeck A/S

NCT04291859

COMPLETED 54 participants

FoxBioNet Pilot Project: SAVE (Synuclein Assay Validation Effort)

Michael J. Fox Foundation for Parkinson's Research

NCT03170063

COMPLETED NA 51 participants

Physiological Effects of Nutritional Support in Patients With Parkinson's Disease

Thomas Jefferson University

NCT02445651

COMPLETED Phase 2 51 participants

Dual-task Augmented Reality Treatment for Parkinson's Disease

The Cleveland Clinic

NCT04634331

COMPLETED NA 50 participants

Pre-Active PD: Looking At Physical Activity Behavior Change in Parkinson's Disease

San Jose State University

NCT05308238

COMPLETED Phase 4 50 participants

Naltrexone for Impulse Control Disorders in Parkinson's Disease

University of Pennsylvania

NCT01052831

COMPLETED 48 participants

Determining the Microbiota Composition of the Middle Meatus in Parkinson's

Rush University Medical Center

NCT03336697

COMPLETED NA 46 participants

Emotion Study/Substudy: Flexible Brain Study

University of Florida

NCT03872414

COMPLETED 45 participants

The Influence of Sensory Stimuli on Gait Imagery in Patients With Freezing of Gait

National Institute of Neurological Disorders and Stroke (NINDS)

NCT01071590

COMPLETED NA 41 participants

Strength Training and Medication Effects in Parkinson Disease Effects on Hypokinesia in Parkinson Disease

University of Utah

NCT00665184

COMPLETED 40 participants

Cognitive Disparities in Parkinson's Disease

Duke University

NCT07262658

COMPLETED Phase 2 40 participants

Levetiracetam Treatment of L-dopa Induced Dyskinesias

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00076674

COMPLETED Phase 3 40 participants

Embryonic Dopamine Cell Implants for Parkinson's Disease

University of Colorado, Denver

NCT00038116

COMPLETED NA 40 participants

Transcutaneous Afferent Patterned Stimulation (TAPS) for Reduction of Parkinson's Disease (PD) Related Action Tremor

Cala Health

NCT05012579

COMPLETED Phase 1 40 participants

A Study to Assess Pharmacokinetic Profiles of LY03003 and Neupro

Luye Pharma Group

NCT03733561

COMPLETED 40 participants

Investigation of Effects of Delayed Feedback on Non-motor Symptoms in Individuals With Parkinson's Disease

Kessler Foundation

NCT06217484

COMPLETED NA 38 participants

Unlocking Dystonia From Parkinson's Disease With Directional DBS Technology

University of Alabama at Birmingham

NCT03409120

COMPLETED NA 35 participants

Golf Instruction Versus Tai Chi for People With Parkinson's Disease

Massachusetts General Hospital

NCT03563807

COMPLETED NA 35 participants

Protective Step Training in Parkinson's Disease

Arizona State University

NCT03895814

COMPLETED NA 35 participants

Training and Parkinson's

University of Miami

NCT03434327

COMPLETED NA 33 participants

Effect of Osteopathic Manipulative Medicine on Parkinson Disease

New York Institute of Technology

NCT02107638

COMPLETED NA 33 participants

Preparing Patient-Caregiver Dyads with Parkinson's Disease for Future Decision Making

Purdue University

NCT05084209

COMPLETED NA 32 participants

Treadmill Training in People With Parkinson's Disease

Georgia State University

NCT05239026

COMPLETED NA 32 participants

Tai Chi for Enhancing Motor and Cognitive Function in Parkinson's Disease

Harvard University Faculty of Medicine

NCT02418780

COMPLETED Phase 2 31 participants

Intranasal Insulin in Parkinson's Disease

HealthPartners Institute

NCT04251585

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Reading the Parkinson Disease Trial Landscape

298 indexed Parkinson Disease studies · 135 recruiting (45%).

Phase mix: 21 late (III/IV) vs 66 early (I/II).

Top sponsor: University of Minnesota (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Parkinson Disease?

PlainTrial tracks 298 US clinical trials for Parkinson Disease, of which 135 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Parkinson Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.