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NCT04675398 · ClinicalTrials.gov registry record · NA
Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson's Disease
A NA study of Parkinson Disease, sponsored by Doris Wang, MD, PhD.
- Active
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04675398 is a NA study of Parkinson Disease that is active but no longer recruiting, run by Doris Wang, MD, PhD. The registered enrollment target is 10 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04675398, a NA study of Parkinson Disease, is active but no longer recruiting, sponsored by Doris Wang, MD, PhD.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single-center phase I clinical study aiming to improve gait functions in patients with Parkinson's disease (PD) by using adaptive neurostimulation to the pallidum. The investigators will use a bidirectional deep brain stimulation device with sensing and stimulation capabilities to 1) decode the physiological signatures of gait and gait adaptation by recording neural activities from the motor cortical areas and the globus pallidus during natural walking and a gait adaptation task, and 2) develop an adaptive deep brain stimulation (DBS) paradigm to selectively stimulate the pallidum during different phases of the gait cycle and measure improvements in gait parameters. This is the first exploration of network dynamics of gait in PD using chronically implanted cortical and subcortical electrodes. In addition to providing insights into a fundamental process, the proposed therapy will deliver personalized neurostimulation based on individual physiological biomarkers to enhance locomotor skills in patients with PD. Ten patients with idiopathic Parkinson's disease undergoing evaluation for DBS implantation will be enrolled in this single treatment arm study.
Conditions Studied
Interventions
- DEVICE Summit RC+S
Study Locations (1)
California
- UCSF - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2021-06-15 |
| Est. Completion | 2030-04-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04675398
The ClinicalTrials.gov registry entry for NCT04675398 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (100% lower). The listed sponsor is Doris Wang, MD, PhD, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Parkinson Disease appearing as the primary indexed condition, and to 1 intervention - of which Summit RC+S is the first listed.
NCT04675398 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT04675398 about?
NCT04675398 is a clinical study titled "Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson's Disease". This is a single-center phase I clinical study aiming to improve gait functions in patients with Parkinson's disease (PD) by using adaptive neurostimulation to the pallidum. The investigators will use a bidirectional deep brain stimulation device with sensing and stimulation capabilities to 1) decod...
What is the current status of trial NCT04675398?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2021-06-15. Estimated completion is 2030-04-01.
What conditions does trial NCT04675398 study?
This clinical trial studies the following conditions: Parkinson Disease.
What interventions are being tested in trial NCT04675398?
The interventions under investigation include: Summit RC+S (DEVICE).
Who is sponsoring clinical trial NCT04675398?
This trial is sponsored by Doris Wang, MD, PhD, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04675398 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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