Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03577730 · ClinicalTrials.gov registry record · Early Phase 1
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
A Early Phase 1 study of Pain, Postoperative, sponsored by University of Michigan.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 71
- Enrollment target
- 1
- Study location
NCT03577730: Completed Early Phase 1 study of Pain, Postoperative, sponsored by University of Michigan.
NCT03577730 is a Early Phase 1 study of Pain, Postoperative that has completed, run by University of Michigan. The registered enrollment target is 71 participants, below the 272-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (74% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03577730, a Early Phase 1 study of Pain, Postoperative, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 71 participants
- Enrollment target
- 1
- Study location
Study Summary
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine reduces pain and opioid requirements after surgery. The investigators will also test whether caffeine improves mood and brain function (e.g., learning, memory) after surgery.
Primary Outcome
Postoperative opioid consumption, oral morphine equivalents (mg)
Conditions Studied
Interventions
- DRUG Dextrose Water
- DRUG Caffeine Citrate
Study Locations (1)
Michigan
- Michigan Medicine - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 71 participants |
| Start Date | 2018-07-10 |
| Est. Completion | 2020-01-17 |
| Phase | Early Phase 1 |
What the finished NCT03577730 record still lists
NCT03577730 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 71 participants, a relatively small participant target, below the 272-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Pain, Postoperative appearing as the primary indexed condition, and to 2 interventions - of which Dextrose Water is the first listed.
NCT03577730 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT03577730 about?
NCT03577730 is a clinical study titled "Caffeine and Neurologic Recovery Following Surgery and General Anesthesia". The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine reduces pain and opioid requ...
What is the current status of trial NCT03577730?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 71 participants. The study started on 2018-07-10. Estimated completion is 2020-01-17.
What conditions does trial NCT03577730 study?
This clinical trial studies the following conditions: Pain, Postoperative.
What interventions are being tested in trial NCT03577730?
The interventions under investigation include: Dextrose Water (DRUG), Caffeine Citrate (DRUG).
Who is sponsoring clinical trial NCT03577730?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03577730 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Postoperative
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03577730's enrollment target sits among peer trials
71 70th of 113 higher than 43 of 113 other Pain, Postoperative trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Postoperative trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Quadratus Lumborum Block for Total Hip Arthroplasty
RECRUITING · Early Phase 1
-
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
RECRUITING · Early Phase 1
-
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
COMPLETED · Early Phase 1
-
Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
RECRUITING · NA
-
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
RECRUITING · Phase 3
-
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05452889 · 71 participants · Early Phase 1
PET Image in PAH Patients
- NCT05766943 · 71 participants · NA
Reduction of Myopotential Interference With Smart Pass in S-ICD Patients
- NCT06229678 · 71 participants · Early Phase 1
Ketones, SGLT2, HFrEF
- NCT06377566 · 71 participants · Phase 2
A Study of BV-AVD in People With Bulky Hodgkin Lymphoma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI