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Pain, Chronic: early-phase trial registry
26 of 49 indexed Pain, Chronic trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #281 of 28,707 conditions by registered trial count.
49 US clinical trials · 26 currently recruiting · #281 of 28,707 conditions by registered trial count
Pain, Chronic: 49 US clinical trials tracked, 26 recruiting.
Pain, Chronic is the subject of 49 registered US clinical trials on ClinicalTrials.gov, 26 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Weill Medical College of Cornell University, running 4 of these trials.
Enrollment posture brief
Registry condition pain-chronic
OPEN 26 | RECR 53% | LATE 1 | EARLY 6 | RANK #281 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Endometriosis (53% recruiting · 49 trials)
Pain, Chronic lists 26 open slots (53% of 49 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain, Chronic on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain, Chronic is recruiting above its size-band peers.
26 of 49 indexed trials (53.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain, Chronic trials is spread across many organizations.
Weill Medical College of Cornell University accounts for 4 of 49 trials (8.2%). 39 distinct sponsors appear on at least one study for this condition label.
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Typical Pain, Chronic enrolment sits around 100 participants.
Median target enrolment is 100 among the 49 trials that report a genuine target (sentinel values excluded). 23 of those (46.9%) plan for fewer than 100 participants.
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Pain, Chronic splits between interventional and observational designs.
34 interventional and 15 observational studies make up this index (69.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
49 total, page 1 of 1
Adolescent Outcomes of Post-operative Opioid EXposure
Sharon Levy
NCT06350409
Evaluation of the PACE/PACENET BHL Clinical Program
University of Pennsylvania
NCT02463266
Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study
Stanford University
NCT05612750
Pain and Opioid Management in Older Adults
University of Oklahoma
NCT05037682
Embo Registry; National Registry for Artery Embolization
Vascular Solutions of North Carolina
NCT06477965
MIVetsCan: Cannabidiol (CBD)-Care Trial
Kevin Boehnke
NCT06213233
Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia
Northwestern University
NCT05703178
Evaluating the Efficacy of the Pain Identification and Communication Toolkit
Weill Medical College of Cornell University
NCT06168604
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
Weill Medical College of Cornell University
NCT06094257
Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
Mayo Clinic
NCT06837857
Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.
University of Illinois at Chicago
NCT06374537
The PROACTIVE Study for Black Elders
University of Florida
NCT06512727
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
Palo Alto Veterans Institute for Research
NCT05700682
Pain Reprocessing Therapy in Post-Operative Knee Pain
University of Colorado, Denver
NCT06800209
Using Technology to Track Pain and Pain-related Outcomes
Johns Hopkins University
NCT04267588
Chronic Pain Diagnosis and Treatment in Torture Survivors
Weill Medical College of Cornell University
NCT04629963
VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain
Northwestern University
NCT06336447
iCanCope With Post-Operative Pain (iCanCope PostOp)
The Hospital for Sick Children
NCT05382962
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
Pain and Weight Treatment: Development and Trial of PAW
Connecticut Children's Medical Center
NCT04046562
Interoceptive Awareness and Function in Adolescents With Chronic Pain
Connecticut Children's Medical Center
NCT07325110
Screening Trial for Pain Relief in Schwannomatosis (STARFISH)
Massachusetts General Hospital
NCT05684692
Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks
University of Pittsburgh
NCT05961800
Light Exposure on Pain in Hypermobile Ehlers-Danlos Syndrome
New York Institute of Technology
NCT05561270
Assessment of Methadone Dose Taken
Cari Health
NCT05981573
Diabetic Neuropathy in Spinal Cord Stimulator Patients
University of Chicago
NCT04687215
More Individualized Care: Assessment and Recovery Through Engagement
Kaiser Permanente
NCT05122676
SPRINT: Signature for Pain Recovery IN Teens
Stanford University
NCT04285112
Resilience Coaching for Adolescents With Chronic Musculoskeletal Pain
Children's Hospital of Philadelphia
NCT05834725
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
Stanford University
NCT04994249
EHR Precision Drug Treatment in Neonates
Children's Hospital Medical Center, Cincinnati
NCT04850079
Acceptability and Efficacy of Pain Reprocessing Therapy in Racially/ Ethnically Diverse Adults With Chronic Back Pain
University of Colorado, Denver
NCT05820204
Neurotechnology Following Traumatic Brain Injury
Brain State Technologies
NCT03649958
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Pain Reduction Through Empowered Recovery (PRIME) Study
Johns Hopkins University
NCT05619510
Sleep Intervention for Chronic Insomnia Using Virtual Reality Pilot Study
University of Missouri-Columbia
NCT04253691
Intermittent vs. Continuous Dorsal Root Ganglion Stimulation
Spine and Pain Institute of New York
NCT04727216
Cognitive Behavioral Therapy for Chronic Pain in Adults With Cerebral Palsy
Hugo W. Moser Research Institute at Kennedy Krieger
NCT06269926
Cooperative Pain Education and Self-management: Expanding Treatment for Real-world Access (COPES ExTRA)
Yale University
NCT03469505
Radiofrequency (RF) Ablation Prospective Outcomes Study
Boston Scientific Corporation
NCT04673032
A Personalized Self-Management Program for Older Adults With Chronic Pain and Negative Emotions
Weill Medical College of Cornell University
NCT03487822
Real-World Experience of Patients Treated for Musculoskeletal Injuries With SAM in Routine Care
ZetrOZ
NCT05254470
Mobile-Based Contingency Management to Promote Daily Self-monitoring in Primary Care Patients
Virginia Commonwealth University
NCT03962491
Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Non-cancer, Refractory, Chronic Pain Population
Evolve Restorative Center
NCT04096391
The Loneliness Epidemic Tailoring Interventions to Reduce Loneliness and Pain
University of Nebraska
NCT05387447
Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Wake Forest University Health Sciences
NCT04156802
Pain Management Support Study for Cancer Survivors
Drexel University
NCT03782506
Examining the Effects of Float-REST for Recovery in Individuals With Chronic Lower Back Pain
West Virginia University
NCT05260918
RTMS for Treatment of Pain and Craving
Medical University of South Carolina
NCT03310138
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 6 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain, Chronic records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain, Chronic trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain, Chronic page
49 registered trials, 26 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 26 Pain, Chronic trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Weill Medical College of Cornell University sponsors the most Pain, Chronic trials on record, review their full trial history before evaluating a specific study. See Weill Medical College of Cornell University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain, Chronic condition card totals 49 registered trials; most-linked intervention Pain reprocessing therapy (PRT); top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.