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NCT05981573 · ClinicalTrials.gov registry record

Assessment of Methadone Dose Taken

A clinical trial of Pain, Chronic and Drug Metabolism, Poor, CYP2D6-Related, sponsored by Cari Health.

Recruiting
Registry status
30
Enrollment target
1
Study location

NCT05981573: Recruiting study of Pain, Chronic and Drug Metabolism, Poor, CYP2D6-Related, sponsored by Cari Health.

NCT05981573 is a study of Pain, Chronic and Drug Metabolism, Poor, CYP2D6-Related that is actively recruiting participants, run by Cari Health. The registered enrollment target is 30 participants, below the 721-participant average among 48 other Pain, Chronic trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05981573, a study of Pain, Chronic and Drug Metabolism, Poor, CYP2D6-Related, is actively recruiting participants, sponsored by Cari Health.

RECRUITING
Registry status
30 participants
Enrollment target
1
Study location

Study Summary

Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication adherence monitor and would allow for the physician, counselor, patient, or family member to remotely verify that a physician-prescribed dose has been taken.

Primary Outcome

Measure the dermal interstitial fluid proteome using LC-MS in subjects without opioid use disorder

Conditions Studied

Pain, Chronic Drug Metabolism, Poor, CYP2D6-Related Methadone Toxicity Methadone Overdose Metabolism Medication Toxicity

Interventions

  • DIAGNOSTIC_TEST Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo
  • DRUG Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo
  • DEVICE ISF Extraction Device 2

Study Locations (1)

California

  • Synergy - Lemon Grove

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2024-08-26
Est. Completion 2026-04
Cari Health

3 total trials

What NCT05981573 shows while recruiting

NCT05981573 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 721-participant average among 48 other Pain, Chronic trials with a reported enrollment target (96% lower).

The record links to 5 conditions, with Pain, Chronic appearing as the primary indexed condition, and to 3 interventions - of which Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo is the first listed.

NCT05981573 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT05981573 about?

NCT05981573 is a clinical study titled "Assessment of Methadone Dose Taken". Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication ...

What is the current status of trial NCT05981573?

This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2024-08-26. Estimated completion is 2026-04.

What conditions does trial NCT05981573 study?

This clinical trial studies the following conditions: Pain, Chronic, Drug Metabolism, Poor, CYP2D6-Related, Methadone Toxicity, Methadone Overdose, Metabolism Medication Toxicity.

What interventions are being tested in trial NCT05981573?

The interventions under investigation include: Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo (DIAGNOSTIC_TEST), Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo (DRUG), ISF Extraction Device 2 (DEVICE).

Who is sponsoring clinical trial NCT05981573?

This trial is sponsored by Cari Health, which has 3 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05981573 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Pain, Chronic

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05981573's enrollment target sits among peer trials

30 40th of 48 higher than 6 of 48 other Pain, Chronic trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Pain, Chronic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05981573

Source: ClinicalTrials.gov NCT05981573, the US trial registry maintained by the National Library of Medicine. NCT05981573 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.