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NCT06800209 · ClinicalTrials.gov registry record · Phase 2
Pain Reprocessing Therapy in Post-Operative Knee Pain
A Phase 2 study of Pain, Chronic and Knee Pain Chronic, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 110
- Enrollment target
- 2
- Study locations
NCT06800209: Recruiting Phase 2 study of Pain, Chronic and Knee Pain Chronic, sponsored by University of Colorado, Denver.
NCT06800209 is a Phase 2 study of Pain, Chronic and Knee Pain Chronic that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 110 participants, below the 719-participant average among 48 other Pain, Chronic trials with a reported enrollment target (85% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06800209, a Phase 2 study of Pain, Chronic and Knee Pain Chronic, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 110 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.
Primary Outcome
Last-week average pain intensity is assessed using the 5-item pain subscale of the 12-item shortened version (ShortMAC) of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The ShortMAC assesses pain severity and its impact on functioning. It consists of 12 total items, including 5 pain items and 7 pain interference items. The 5 pain items measure pain on a scale of 0-4, with 0 indicating no pain and 4 indicating extreme pain.
Conditions Studied
Interventions
- OTHER Usual care
- BEHAVIORAL Pain reprocessing therapy (PRT)
Study Locations (2)
Colorado
- University of Colorado Anschutz Medical Campus - Aurora
New York
- Hospital for Special Surgery - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2025-08-13 |
| Est. Completion | 2028-09-30 |
| Phase | Phase 2 |
What NCT06800209 shows while recruiting
NCT06800209 is an interventional study that assigns participants to a tested intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 719-participant average among 48 other Pain, Chronic trials with a reported enrollment target (85% lower).
The record links to 2 conditions, with Pain, Chronic appearing as the primary indexed condition, and to 2 interventions - of which Usual care is the first listed.
NCT06800209 reports a single indexed study location in Colorado, New York.
Frequently Asked Questions
What is clinical trial NCT06800209 about?
NCT06800209 is a clinical study titled "Pain Reprocessing Therapy in Post-Operative Knee Pain". The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questio...
What is the current status of trial NCT06800209?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 110 participants. The study started on 2025-08-13. Estimated completion is 2028-09-30.
What conditions does trial NCT06800209 study?
This clinical trial studies the following conditions: Pain, Chronic, Knee Pain Chronic.
What interventions are being tested in trial NCT06800209?
The interventions under investigation include: Usual care (OTHER), Pain reprocessing therapy (PRT) (BEHAVIORAL).
Who is sponsoring clinical trial NCT06800209?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06800209 being conducted?
This trial has 2 study locations across Colorado, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Chronic
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06800209's enrollment target sits among peer trials
110 24th of 48 higher than 25 of 48 other Pain, Chronic trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Chronic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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