Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06837857 · ClinicalTrials.gov registry record · Phase 2
Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
A Phase 2 study of Pain, Chronic, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT06837857: Recruiting Phase 2 study of Pain, Chronic, sponsored by Mayo Clinic.
NCT06837857 is a Phase 2 study of Pain, Chronic that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 200 participants, below the 717-participant average among 48 other Pain, Chronic trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06837857, a Phase 2 study of Pain, Chronic, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by fractional anisotropy of the corpus callosum.
Primary Outcome
Fractional anisotropy of the corpus callosum, adjusted against baseline value.
Conditions Studied
Interventions
- DRUG Opioid
- DRUG Opioid Placebo
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-04-16 |
| Est. Completion | 2029-12-31 |
| Phase | Phase 2 |
What NCT06837857 shows while recruiting
NCT06837857 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 717-participant average among 48 other Pain, Chronic trials with a reported enrollment target (72% lower).
The record links to 1 condition, with Pain, Chronic appearing as the primary indexed condition, and to 2 interventions - of which Opioid is the first listed.
NCT06837857 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT06837857 about?
NCT06837857 is a clinical study titled "Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain". The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by fractional anisotropy of the corpus callosum.
What is the current status of trial NCT06837857?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 200 participants. The study started on 2025-04-16. Estimated completion is 2029-12-31.
What conditions does trial NCT06837857 study?
This clinical trial studies the following conditions: Pain, Chronic.
What interventions are being tested in trial NCT06837857?
The interventions under investigation include: Opioid (DRUG), Opioid Placebo (DRUG).
Who is sponsoring clinical trial NCT06837857?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06837857 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Chronic
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06837857's enrollment target sits among peer trials
200 16th of 48 higher than 32 of 48 other Pain, Chronic trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Chronic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Screening Trial for Pain Relief in Schwannomatosis (STARFISH)
RECRUITING · Phase 2
-
Pain Reprocessing Therapy in Post-Operative Knee Pain
RECRUITING · Phase 2
-
MIVetsCan: Cannabidiol (CBD)-Care Trial
RECRUITING · Phase 2
-
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
ACTIVE NOT RECRUITING · Phase 2
-
RTMS for Treatment of Pain and Craving
COMPLETED · Phase 2
-
Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00107289 · 200 participants · Phase 2
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma
- NCT00109174 · 200 participants · NA
MRS Measurement of Glutamate and GABA Metabolism in Brain
- NCT00177268 · 200 participants
Blood, Urine, and Tissue Collection for Cutaneous Lymphoma, Eczema, and Atopic Dermatitis Research
- NCT00493688 · 200 participants
A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI