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Opioid Use Disorder: early-phase trial registry
156 of 258 indexed Opioid Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #40 of 28,707 conditions by registered trial count.
258 US clinical trials · 156 currently recruiting · #40 of 28,707 conditions by registered trial count
Opioid Use Disorder: 258 US clinical trials tracked, 156 recruiting.
Opioid Use Disorder is the subject of 258 registered US clinical trials on ClinicalTrials.gov, 156 of them currently open to new participants. 23 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 19 of these trials.
Enrollment posture brief
Registry condition opioid-use-disorder
OPEN 156 | RECR 60% | LATE 23 | EARLY 59 | RANK #40 | SPON 19
Volume-matched condition peers
Nearest open-share peer: HIV Prevention (61% recruiting · 33 trials)
Opioid Use Disorder lists 156 open slots (60% of 258 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Use Disorder is recruiting above its size-band peers.
156 of 258 indexed trials (60.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Opioid Use Disorder trials is spread across many organizations.
Yale University accounts for 19 of 258 trials (7.4%). 127 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Use Disorder enrolment sits around 103 participants.
Median target enrolment is 103 among the 258 trials that report a genuine target (sentinel values excluded). 121 of those (46.9%) plan for fewer than 100 participants.
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Opioid Use Disorder research is mostly interventional.
233 interventional and 25 observational studies make up this index (90.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
258 total, page 4 of 6
Neuroplasticity in Maternal Opioid Use Disorder (OUD)
Yale University
NCT05495984
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
Yale University
NCT06160284
Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine
University of Wisconsin, Madison
NCT04161066
Longitudinal Neural Fingerprinting of Opioid-use Trajectories
Yale University
NCT06207162
Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain
Arizona State University
NCT06947122
Deep Brain Stimulation Effects In Patients With Opioid Use Disorder
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT04354077
Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD
Kaiser Permanente
NCT05944133
Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care
Kaiser Permanente
NCT05160233
Mobile Peer Support for OUD Recovery
Brown University
NCT05405712
STEPuP: Prenatal Provider Education and Training to Improve Medication-assisted Treatment Use During Pregnancy
University of Pittsburgh
NCT04527926
Kentucky Women's Justice Community Opioid Innovation Network
Michele Staton
NCT04069624
Adapting the HOPE Online Support Intervention to Increase Uptake of Medications for Opioid Use Disorder
University of California, Irvine
NCT04712981
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations
Yale University
NCT05286879
The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions
University of Pennsylvania
NCT04245423
The Emergency Department Longitudinal Integrated Care
University of Washington
NCT05327166
Recovery Management Checkups for Opioid Use Disorder Experiment
Chestnut Health Systems
NCT04365920
Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder
Public Health Management Corporation
NCT06359340
Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder
Philadelphia College of Osteopathic Medicine
NCT04257214
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
University of Colorado, Denver
NCT04664062
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
Erin Winstanley
NCT06367387
Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD)
University of Arkansas
NCT05776823
Pain Care at Home to Amplify Function (Pain CHAMP)
Yale University
NCT05333341
Extended Release Naltrexone Versus Extended Release Buprenorphine With Individuals Leaving Jail
Friends Research Institute
NCT04408313
Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use
University of California, Los Angeles
NCT04808479
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; R33 Phase)
Case Western Reserve University
NCT05688410
Contingency Management for Drug Use: Does Age Matter?
Wake Forest University Health Sciences
NCT05521854
ED Observation for Opioid Use Disorder
NYU Langone Health
NCT05064826
Sublingual Dexmedetomidine for Treating Opioid Withdrawal
New York State Psychiatric Institute
NCT05712707
Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
University of New Mexi
NCT05571917
Pain and Opioids: Integrated Treatment In Veterans
University of New Mexi
NCT04648228
Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT
BehaVR
NCT06021431
NET Device for Treating Opioid Use Disorder
Wayne State University
NCT04916600
Evaluating Buspirone to Treat Opioid Withdrawal
Johns Hopkins University
NCT05511909
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)
Case Western Reserve University
NCT04736550
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Contingency Management for Opioid and Stimulant Use Disorders in Primary Care
University of Minnesota
NCT05288751
Peer Recovery Support Services for Individuals in Recovery Residences on MOUD
Potomac Health Foundations
NCT05616949
MHealth Incentivized Adherence Plus Patient Navigation
University of Washington
NCT06027814
Maternal Brain Imaging in Opioid Use Disorder
Indiana University
NCT06008990
Low-dose Versus a High-dose Sublingual Buprenorphine Induction
Friends Research Institute
NCT05944952
E-cigarette Switching Older Adults
University of Maryland, Baltimore
NCT06534905
Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering
Washington State University
NCT05924022
rTMS, Stress and Opioid Use Disorder
Wayne State University
NCT04920864
Effective Caregiving for Neonatal Abstinence Syndrome: Testing an Instructional Mobile Technology Platform for High-Risk Pregnant Women
Washington State University
NCT04783558
Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People
Medical University of South Carolina
NCT06496230
Buprenorphine Integration Research and Community Health
Yale University
NCT05668780
Therapy for People With Opioid Use Disorder
Philadelphia College of Osteopathic Medicine
NCT06008769
tAN for PTSD and OUD in Buprenorphine Therapy
University of Cincinnati
NCT06130501
Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals With Co-Occurring Internalizing Disorders
University of Minnesota
NCT06545071
Continuous And Data-drivEN CarE (CADENCE) Pilot
University of South Florida
NCT05609669
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 11 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Use Disorder page
258 registered trials, 156 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 156 Opioid Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Opioid Use Disorder trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Use Disorder condition card totals 258 registered trials; most-linked intervention Placebo; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.