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NCT04920864 · ClinicalTrials.gov registry record · NA
rTMS, Stress and Opioid Use Disorder
A NA study of Opioid Use Disorder, sponsored by Wayne State University.
- Active
- Registry status
- NA
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT04920864: Active NA study of Opioid Use Disorder, sponsored by Wayne State University.
NCT04920864 is a NA study of Opioid Use Disorder that is active but no longer recruiting, run by Wayne State University. The registered enrollment target is 32 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04920864, a NA study of Opioid Use Disorder, is active but no longer recruiting, sponsored by Wayne State University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
Opioid agonist treatments are the gold standard for treating opioid use disorder (OUD). Yet, even effective treatments average only 50% six-month retention. Despite extensive research into treatment options, it remains important to improve understanding of factors that contribute to relapse and identify interventions to mitigate these risks. Stress-exposure is problematic for people trying to recover from substance use disorders (SUDs) because it weakens inhibition of automatic behaviors and increases drug craving and likelihood of relapse. However, paths through which stress affects behavior are incompletely understood and current SUD treatments do not target effects of stress on drug use. This project will explore whether repetitive transcranial magnetic stimulation (rTMS) might improve treatment outcomes for people with OUD entering methadone treatment. The investigators will examine the impact of rTMS treatment over one of two theoretically-driven neural targets on substance use and cognitive outcomes associated with treatment success (executive function and emotional arousal).
Primary Outcome
Wisconsin Card Sorting Task perseverance measures cognitive flexibility as an index of executive function. Higher scores reflect better outcome.
Conditions Studied
Interventions
- DEVICE rTMS
Study Locations (1)
Michigan
- Tolan Park Medical Building - Detroit
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2022-04-01 |
| Est. Completion | 2026-12 |
| Phase | NA |
What the registry record for NCT04920864 still lists
NCT04920864 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 1 intervention - of which rTMS is the first listed.
NCT04920864 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT04920864 about?
NCT04920864 is a clinical study titled "rTMS, Stress and Opioid Use Disorder". Opioid agonist treatments are the gold standard for treating opioid use disorder (OUD). Yet, even effective treatments average only 50% six-month retention. Despite extensive research into treatment options, it remains important to improve understanding of factors that contribute to relapse and iden...
What is the current status of trial NCT04920864?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 32 participants. The study started on 2022-04-01. Estimated completion is 2026-12.
What conditions does trial NCT04920864 study?
This clinical trial studies the following conditions: Opioid Use Disorder.
What interventions are being tested in trial NCT04920864?
The interventions under investigation include: rTMS (DEVICE).
Who is sponsoring clinical trial NCT04920864?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04920864 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Opioid Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04920864's enrollment target sits among peer trials
32 202nd of 257 higher than 54 of 257 other Opioid Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Opioid Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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