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Opioid Use Disorder: early-phase trial registry
156 of 258 indexed Opioid Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #40 of 28,707 conditions by registered trial count.
258 US clinical trials · 156 currently recruiting · #40 of 28,707 conditions by registered trial count
Opioid Use Disorder: 258 US clinical trials tracked, 156 recruiting.
Opioid Use Disorder is the subject of 258 registered US clinical trials on ClinicalTrials.gov, 156 of them currently open to new participants. 23 are in Phase 3-4 (later-stage) and 59 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 19 of these trials.
Enrollment posture brief
Registry condition opioid-use-disorder
OPEN 156 | RECR 60% | LATE 23 | EARLY 59 | RANK #40 | SPON 19
Volume-matched condition peers
Nearest open-share peer: HIV Prevention (61% recruiting · 33 trials)
Opioid Use Disorder lists 156 open slots (60% of 258 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid Use Disorder is recruiting above its size-band peers.
156 of 258 indexed trials (60.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Opioid Use Disorder trials is spread across many organizations.
Yale University accounts for 19 of 258 trials (7.4%). 127 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid Use Disorder enrolment sits around 103 participants.
Median target enrolment is 103 among the 258 trials that report a genuine target (sentinel values excluded). 121 of those (46.9%) plan for fewer than 100 participants.
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Opioid Use Disorder research is mostly interventional.
233 interventional and 25 observational studies make up this index (90.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
258 total, page 5 of 6
Pilot Research on Opioid Use Disorder
Theranova, L.L.C.
NCT04244227
PRimary Care Opioid Use Disorders Treatment (PROUD) Trial
Kaiser Permanente
NCT03407638
Natural Language Processing for Screening Opioid Misuse
University of Wisconsin, Madison
NCT05745480
Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid
NYU Langone Health
NCT04632238
Patient Decision Aid for Opioid Use Disorder
University of California, Los Angeles
NCT03568552
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Opioid-Naive Population
University of Minnesota
NCT04601493
An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery
Indivior
NCT03604861
OXD01 in Combination With Sublingual Buprenorphine/Naloxone for Treatment of Opioid Use Disorder
Orexo AB
NCT04948307
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
Alkermes
NCT02537574
Parenting Young Children Study
University of Oregon
NCT05180487
SMART Trial for Buprenorphine-Naloxone Medication Assisted Treatment Adherence
Karen Derefinko, PhD
NCT04080180
Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment (R33 Phase)
Cambridge Health Alliance
NCT04278586
Technology for MAT in Primary Care - Phase 2
Q2i
NCT05017272
Treatment of Pregnant Women With OUD
Yale University
NCT04240392
Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder
Braeburn Pharmaceuticals
NCT02672111
A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail
Friends Research Institute
NCT02334215
Open-Label Treatment Extension Study
Indivior
NCT02896296
Reducing Pain and Opioid Use With CBD
University of Colorado, Denver
NCT05299944
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
HealthPartners Institute
NCT04939727
Enhancing Prospective Thinking in Early Recovery (PARK)
Indiana University
NCT05908097
Rapid Initiation of Drug Treatment Engagement
University of Pennsylvania
NCT03908437
Substance Use Treatment and Recovery Team (START)
RAND
NCT04314648
Transforming Recovery Through Exercise and Community
Butler Hospital
NCT03065049
Pilot Test of Patient Decision Aid for Opioid Use Disorder
University of California, Los Angeles
NCT03394261
Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections
Laura Fanucchi
NCT04677114
Phase II Pharmacokinetics Study of CAM2038
Braeburn Pharmaceuticals
NCT02710526
Harnessing Digital Health to Understand Clinical Trajectories of Opioid Use Disorder
Dartmouth-Hitchcock Medical Center
NCT04535583
Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction
Ohio State University
NCT03791645
BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control
Grace Lim, MD, MS
NCT04365465
Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
HealthPartners Institute
NCT03559179
Emergency Department Outcomes for Patients With Opioid Use Disorder
NYU Langone Health
NCT04289363
Evaluation of Long-term Buprenorphine Plasma Exposure
Indivior
NCT03752528
Testing of the Integrated Rapid Access to HIV Prevention Program for People Who Inject Drugs Program
University of Connecticut
NCT04531670
Culturally Centering Medications for Opioid Use Disorder With American Indian and Alaska Native Communities
New York State Psychiatric Institute
NCT04958798
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
Boston Medical Center
NCT03718104
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03662529
Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
Spark Biomedical
NCT04075214
Digital Therapeutic Development of Virtual Cognitive-Affective Training for Opioid Use Disorder
University of Utah
NCT05034276
Computerized Anxiety Sensitivity Treatment for Opioid Use Disorders
Southeast Louisiana Veterans Health Care System
NCT03944850
Philly NavSTAR Implementation Trial
Friends Research Institute
NCT06634277
Cocaine Opioid Oxytocin Option - Limited
University of California, San Francisco
NCT02028533
Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.
Brigham and Women's Hospital
NCT03212794
Effect of Music on Cue Reactivity for Patients With Opioid Use Disorder
Brigham and Women's Hospital
NCT06948890
MySafeRx™: An Integrated Mobile Platform for Buprenorphine Adherence
Dartmouth-Hitchcock Medical Center
NCT02778282
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants
Astellas Pharma Global Development
NCT04448561
AWAITS: A Web-based E-health Application for Active Illicit Opioid Users
University of Cincinnati
NCT03402672
Repetitive Transcranial Magnetic Stimulation to Reduce Heroin Cravings
University of Nevada, Las Vegas
NCT05074524
Opioid Treatment Program (OTP)-Pharmacy Collaboration for Methadone Maintenance Treatment
Friends Research Institute
NCT04308694
Tai Chi Easy for Opioid Use Disorder, Anxiety, and Chronic Pain
Asana Recovery
NCT05850533
mHealth for Patient Self-Management of Opioid Use Disorder
Biomedical Development Corporation
NCT03633929
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 11 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid Use Disorder page
258 registered trials, 156 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 156 Opioid Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Opioid Use Disorder trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid Use Disorder condition card totals 258 registered trials; most-linked intervention Placebo; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.