Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
HIV Prevention: early-phase trial registry
20 of 33 indexed HIV Prevention trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #463 of 28,707 conditions by registered trial count.
33 US clinical trials · 20 currently recruiting · #463 of 28,707 conditions by registered trial count
HIV Prevention: 33 US clinical trials tracked, 20 recruiting.
HIV Prevention is the subject of 33 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 3 of these trials.
Enrollment posture brief
Registry condition hiv-prevention
OPEN 20 | RECR 61% | LATE 2 | EARLY 4 | RANK #463 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Metastatic Breast Carcinoma (61% recruiting · 33 trials)
HIV Prevention lists 20 open slots (61% of 33 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for HIV Prevention on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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HIV Prevention is recruiting above its size-band peers.
20 of 33 indexed trials (60.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of HIV Prevention trials is spread across many organizations.
Johns Hopkins University accounts for 3 of 33 trials (9.1%). 23 distinct sponsors appear on at least one study for this condition label.
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Typical HIV Prevention enrolment sits around 101 participants.
Median target enrolment is 101 among the 33 trials that report a genuine target (sentinel values excluded). 13 of those (39.4%) plan for fewer than 100 participants.
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HIV Prevention research is mostly interventional.
28 interventional and 5 observational studies make up this index (84.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
33 total, page 1 of 1
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
University of California, Los Angeles
NCT05018611
Using PrEP, Doing It for Ourselves
Duke University
NCT06638892
Suubi4PrEP: Improving PrEP Access and Adherence Among Adolescent Girls and Young Women in Uganda
Washington University School of Medicine
NCT07002866
Hybrid Evaluation of a Home-based HIV Pre-exposure Prophylaxis Program
University of Washington
NCT05856942
Client-Centered Care Coordination for Black Men Who Have Sex With Men
University of Maryland, Baltimore
NCT06056544
California MEPS Hub
University of California, Los Angeles
NCT07433985
Intervention to Enhance PrEP Persistence
Brown University
NCT06872307
A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women
Johns Hopkins Bloomberg School of Public Health
NCT06703060
Testing a Gender-inclusive HIV Prevention Program
Center for Innovative Public Health Research
NCT06586151
Stick2PrEP Cisgender Women and Trans Individuals
Columbia University
NCT05165745
HIV Outpatient Monitoring Evaluation Through Self-collection of Dried Blood Spots
University of Colorado, Denver
NCT04979728
The Unlocking PrEP Study: Integration of Peer Health Navigation Into Comprehensive Re-entry Services
University of Texas Southwestern Medical Center
NCT07292792
Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP
Duke University
NCT07218211
Safe Spaces 4 Sexual Health
Johns Hopkins University
NCT07133555
WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women
University of Colorado, Denver
NCT06656676
An Acceptance Based PrEP Intervention to Engage Young Black MSM in the South
Rhode Island Hospital
NCT05087680
Behavioral Economic Intervention to Improve HIV Behaviors in Sexual Minority Individuals
The University of Texas Health Science Center at San Antonio
NCT06745947
PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking
University of Alabama at Birmingham
NCT07231640
Prepping for The Talk: Helping Trusted Adults and Youth Talk About Sexual Health
Rhode Island Hospital
NCT07011563
Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers
Johns Hopkins University
NCT07349758
Clinic-based HIV Identification and Prevention Project Using Electronic Resources
Johns Hopkins University
NCT05412433
Integrated HIV Prevention and HCV Care for PWID
Columbia University
NCT03981445
PrEP Affect Regulation Treatment Innovation
Florida International University
NCT04899024
Pre-Exposure Prophylaxis for Transgender Women in the US and South America
HIV Prevention Trials Network
NCT04742491
Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use
University of Washington
NCT03112369
In Vivo Drug Interaction Pharmacokinetic Study of Tenofovir 1% Gel and Three Commonly Used Vaginal Products
CONRAD
NCT01813162
Addressing Health Disparities in Engagement, Retention, and Utilization of PrEP Among South Florida Women of Color
Florida International University
NCT05338996
Implantable Long-Acting Pre-Exposure Prophylaxis For MSM
Elizabeth Arnold
NCT05420207
Biomarkers of Protocol Compliance and Product Adherence
CONRAD
NCT01804023
Study for IFE4PrEP Intervention on PrEP Uptake by Southern African American Women
University of North Carolina, Chapel Hill
NCT05087927
Formative Research for an HIV Videogame for Young Black Women
Yale University
NCT02685410
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
Public Health Foundation Enterprises
NCT03387462
An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations
Ian McGowan
NCT01575418
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on HIV Prevention records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on HIV Prevention trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this HIV Prevention page
33 registered trials, 20 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 20 HIV Prevention trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most HIV Prevention trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This HIV Prevention condition card totals 33 registered trials; most-linked intervention Control; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.