Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
HIV Prevention
Open-data reference.
33 US clinical trials · 20 currently recruiting
Active & Recent Trials
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
University of California, Los Angeles
NCT05018611
Using PrEP, Doing It for Ourselves
Duke University
NCT06638892
Suubi4PrEP: Improving PrEP Access and Adherence Among Adolescent Girls and Young Women in Uganda
Washington University School of Medicine
NCT07002866
Hybrid Evaluation of a Home-based HIV Pre-exposure Prophylaxis Program
University of Washington
NCT05856942
Client-Centered Care Coordination for Black Men Who Have Sex With Men
University of Maryland, Baltimore
NCT06056544
California MEPS Hub
University of California, Los Angeles
NCT07433985
Intervention to Enhance PrEP Persistence
Brown University
NCT06872307
A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women
Johns Hopkins Bloomberg School of Public Health
NCT06703060
Testing a Gender-inclusive HIV Prevention Program
Center for Innovative Public Health Research
NCT06586151
Stick2PrEP Cisgender Women and Trans Individuals
Columbia University
NCT05165745
HIV Outpatient Monitoring Evaluation Through Self-collection of Dried Blood Spots
University of Colorado, Denver
NCT04979728
The Unlocking PrEP Study: Integration of Peer Health Navigation Into Comprehensive Re-entry Services
University of Texas Southwestern Medical Center
NCT07292792
Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP
Duke University
NCT07218211
Safe Spaces 4 Sexual Health
Johns Hopkins University
NCT07133555
WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women
University of Colorado, Denver
NCT06656676
An Acceptance Based PrEP Intervention to Engage Young Black MSM in the South
Rhode Island Hospital
NCT05087680
Behavioral Economic Intervention to Improve HIV Behaviors in Sexual Minority Individuals
The University of Texas Health Science Center at San Antonio
NCT06745947
PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking
University of Alabama at Birmingham
NCT07231640
Prepping for The Talk: Helping Trusted Adults and Youth Talk About Sexual Health
Rhode Island Hospital
NCT07011563
Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers
Johns Hopkins University
NCT07349758
Clinic-based HIV Identification and Prevention Project Using Electronic Resources
Johns Hopkins University
NCT05412433
Integrated HIV Prevention and HCV Care for PWID
Columbia University
NCT03981445
PrEP Affect Regulation Treatment Innovation
Florida International University
NCT04899024
Pre-Exposure Prophylaxis for Transgender Women in the US and South America
HIV Prevention Trials Network
NCT04742491
Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use
University of Washington
NCT03112369
In Vivo Drug Interaction Pharmacokinetic Study of Tenofovir 1% Gel and Three Commonly Used Vaginal Products
CONRAD
NCT01813162
Addressing Health Disparities in Engagement, Retention, and Utilization of PrEP Among South Florida Women of Color
Florida International University
NCT05338996
Implantable Long-Acting Pre-Exposure Prophylaxis For MSM
Elizabeth Arnold
NCT05420207
Biomarkers of Protocol Compliance and Product Adherence
CONRAD
NCT01804023
Study for IFE4PrEP Intervention on PrEP Uptake by Southern African American Women
University of North Carolina, Chapel Hill
NCT05087927
Formative Research for an HIV Videogame for Young Black Women
Yale University
NCT02685410
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
Public Health Foundation Enterprises
NCT03387462
An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations
Ian McGowan
NCT01575418
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Prevention Trial Landscape
ClinicalTrials.gov lists 33 US studies indexed under HIV Prevention, and 20 of those are currently open to recruitment — roughly 61% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for HIV Prevention shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for HIV Prevention is led by Johns Hopkins University with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 33 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV Prevention?
PlainTrial tracks 33 US clinical trials for HIV Prevention, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV Prevention?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.