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Obesity: early-phase trial registry
306 of 1,057 indexed Obesity trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3 of 28,707 conditions by registered trial count.
1,057 US clinical trials · 306 currently recruiting · #3 of 28,707 conditions by registered trial count
Obesity: 1,057 US clinical trials tracked, 306 recruiting.
Obesity is the subject of 1,057 registered US clinical trials on ClinicalTrials.gov, 306 of them currently open to new participants. 107 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 48 of these trials.
Enrollment posture brief
Registry condition obesity
OPEN 306 | RECR 29% | LATE 107 | EARLY 196 | RANK #3 | SPON 48
Volume-matched condition peers
Nearest open-share peer: Metastatic Pancreatic Adenocarcinoma (29% recruiting · 38 trials)
Obesity lists 306 open slots (29% of 1,057 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obesity on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obesity is recruiting below its size-band peers.
306 of 1,057 indexed trials (28.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obesity trials is spread across many organizations.
Eli Lilly and Company accounts for 48 of 1,057 trials (4.5%). 314 distinct sponsors appear on at least one study for this condition label.
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Typical Obesity enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,054 trials that report a genuine target (sentinel values excluded). 555 of those (52.7%) plan for fewer than 100 participants.
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Obesity research is mostly interventional.
894 interventional and 163 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,057 total, page 21 of 22
Vitamin D and Adipose Tissue Inflammation
Fred Hutchinson Cancer Center
NCT01477034
Pharmacokinetics of Implanon in Obese Women
University of Chicago
NCT00724438
The Natriuretic Peptide Response to Saline Infusion
Vanderbilt University Medical Center
NCT04223531
Impact of Metabolic Flexibility on Changes in Metabolic Health
Pennington Biomedical Research Center
NCT06340321
Child Care Wellness Study on Nutrition and Physical Activity
University of North Carolina, Chapel Hill
NCT01921842
Preventing Weight Gain in African American Reproductive-Aged Women
Washington University School of Medicine
NCT02416921
Preparing a Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control
University of Illinois at Chicago
NCT05796648
A Trial of Lifestyle Interventions to Control Weight After Bariatric Surgery
Beth Israel Deaconess Medical Center
NCT02603601
Obesity, Iron Regulation and Colorectal Cancer Risk
University of Illinois at Chicago
NCT03548948
ClockWork Postpartum Weight Management Study
University of Pittsburgh
NCT04992637
Neurohormonal & Behavioral Correlates of Obesity and Weight Loss
University of Michigan
NCT02063451
Whole Grains, Gastric Emptying and Glycemic Response
Purdue University
NCT03467659
Characterization of Bile Acid Pathway in Obesity
Mayo Clinic
NCT03341052
Acute Exercise on Brain Insulin Sensitivity
Rutgers, The State University of New Jersey
NCT05853913
Exercise and Nutrition Program in Improving Physical Activity and Dietary Behavior in Non-Active, Overweight, or Obese Latinas
OHSU Knight Cancer Institute
NCT03028935
Effects of Regular Activity on Physiology Between Recreational Athletes of Different Body Fatness
Florida State University
NCT05154422
Effect of Food Order on Postprandial Glucose Excursions in Pre-Diabetes
Weill Medical College of Cornell University
NCT03536364
Free-Living Physical Activity and Energy Expenditure
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00062998
Effects of Exercise on Cardiac Fat in Women With Obesity: a Pilot Study
Texas Tech University
NCT02589327
WorkWell: Work-based Activity and Metabolic Health
Arizona State University
NCT04269070
Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents
Yale University
NCT01901978
Effect of Administration of Itraconazole on the Pharmacokinetics of S-309309 in Healthy Participants
Shionogi
NCT06106334
Identification of Muscle-specific Biomarkers of Fatty Acid Beta-oxidation
USDA, Western Human Nutrition Research Center
NCT01494025
Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance
National Heart, Lung, and Blood Institute (NHLBI)
NCT01862757
Glycomacropeptide and Women's Health
University of Wisconsin, Madison
NCT05551091
Sleep, Exercise and Insulin Sensitivity
University of Missouri-Columbia
NCT03556410
The Effects of Alcohol Consumption on Central Adiposity
Pennington Biomedical Research Center
NCT03521817
The Effect of Bariatric Surgery on Metabolism, the Metabolome and Microbiome in Patients With Type 2 Diabetes
Mayo Clinic
NCT02762708
A Study to Evaluate the Effect of Lipid Infusion on Toll Like Receptor 4 (TLR4) Signaling
The University of Texas Health Science Center at San Antonio
NCT01740817
Work-Related Effects of Heat, Activity, and Fat in Middle Aged Men
Freeman-Sheldon Research Group
NCT02532725
FFA Hypertension and Inflammation in Lean and Obese Subjects
Emory University
NCT00721617
PACE-CALL: A Weight Control Intervention for Survivors of Childhood Leukemia
University of California, San Diego
NCT01171599
Online Resources to Manage Obesity and Health Risks in an Employee Wellness Program
Vanderbilt University
NCT01122420
Virtual Enhanced Lifestyle for Metabolic Syndrome (ELM) Proof-of-Concept Study
Rush University Medical Center
NCT04637477
Implementation of a Cardiometabolic Disease Staging System in Primary Care
University of Alabama at Birmingham
NCT04922294
Mediators of Abnormal Reproductive Function in Obesity (MARO)
University of Colorado, Denver
NCT01817400
Endoscopic Gastric Reduction for Weight Management
Mayo Clinic
NCT01682733
Sleep Restriction and Postprandial Lipemia
University of Missouri-Columbia
NCT05713370
Sex Differences in Gene Expression in Human Adipose Tissue
University of California, San Diego
NCT00677651
Kid STRIDE: Exploring Participation in a Family-based Intervention
University of Wisconsin, Madison
NCT00682422
Celecoxib Inhibition of Aromatase Expression and Inflammation in Adipose Tissue of Obese Postmenopausal Women
Rockefeller University
NCT01901679
Influence of a Monopoly Game on Subtle Behaviors
University of Colorado, Denver
NCT02470949
Endoscopic Suturing System for Tissue Apposition
Ethicon Endo-Surgery
NCT00495222
The Effects of Leucine on Body Weight
Columbia University
NCT00683826
Effects of Exercise for Overweight Women With Polycystic Ovary Syndrome
Pennington Biomedical Research Center
NCT01150539
Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
University of North Carolina, Chapel Hill
NCT02237872
Timing of Meals for Weight Loss
The University of Tennessee, Knoxville
NCT02204735
Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health
Washington University School of Medicine
NCT02706288
Fatty Acid Metabolism and Insulin Sensitivity After Exercise in Obesity
University of Michigan
NCT01451957
Effects of Glucagon Administration on Energy Expenditure
AdventHealth Translational Research Institute
NCT02237053
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 101 |
| Phase 3 | 69 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Obesity records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obesity trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obesity page
1,057 registered trials, 306 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 306 Obesity trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Eli Lilly and Company sponsors the most Obesity trials on record, review their full trial history before evaluating a specific study. See Eli Lilly and Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obesity condition card totals 1,057 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.