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NCT06340321 · ClinicalTrials.gov registry record
Impact of Metabolic Flexibility on Changes in Metabolic Health
A clinical trial of Obesity and Metabolic Syndrome, sponsored by Pennington Biomedical Research Center.
- Completed
- Registry status
- 18
- Enrollment target
- 1
- Study location
NCT06340321: Completed study of Obesity and Metabolic Syndrome, sponsored by Pennington Biomedical Research Center.
NCT06340321 is a study of Obesity and Metabolic Syndrome that has completed, run by Pennington Biomedical Research Center. The registered enrollment target is 18 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06340321, a study of Obesity and Metabolic Syndrome, has completed, sponsored by Pennington Biomedical Research Center.
- COMPLETED
- Registry status
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands. Thus, for example, increases in glucose availability after a meal would increase glucose oxidation, while increases in lipid availability during fasting would increase lipid oxidation. Enhanced metabolic flexibility has been proposed to protect humans from metabolic diseases. Nevertheless, most studies examining associations between metabolic flexibility and metabolic health outcomes have used cross-sectional designs. Whether impaired metabolic flexibility causes or results from metabolic health impairment is thus unclear. In this study, the investigators will use the data from a study conducted approximately 16 years ago in healthy participants without obesity. Using the data already collected in that study, the metabolic flexibility of each participant will be calculated. To test the association between metabolic flexibility and the change in metabolic health, the investigators will call back all the participants for a single follow-up visit to reassess several metabolic health outcomes. Thus, the main aim of the study is to test the association between metabolic flexibility and the change in metabolic health outcomes after 16 years in humans.
Primary Outcome
Circulating concentration of glucose in mg/dL
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Metabolic flexibility in the fasted state
- OTHER Metabolic flexibility in euglycemic-hyperinsulinemic clamp
- OTHER Metabolic flexibility in the metabolic chamber
Study Locations (1)
Louisiana
- Pennington Biomedical Research Center - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2024-10-09 |
| Est. Completion | 2025-08-27 |
What the finished NCT06340321 record still lists
NCT06340321 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 3 interventions - of which Metabolic flexibility in the fasted state is the first listed.
NCT06340321 reports a single indexed study location in Louisiana.
Frequently Asked Questions
What is clinical trial NCT06340321 about?
NCT06340321 is a clinical study titled "Impact of Metabolic Flexibility on Changes in Metabolic Health". Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands. Thus, for example, increases in glucose availability after a meal would increase glucose oxidation, while increases in lipid availability during fasting would incr...
What is the current status of trial NCT06340321?
This trial is currently completed. The enrollment target is 18 participants. The study started on 2024-10-09. Estimated completion is 2025-08-27.
What conditions does trial NCT06340321 study?
This clinical trial studies the following conditions: Obesity, Metabolic Syndrome.
What interventions are being tested in trial NCT06340321?
The interventions under investigation include: Metabolic flexibility in the fasted state (DIAGNOSTIC_TEST), Metabolic flexibility in euglycemic-hyperinsulinemic clamp (OTHER), Metabolic flexibility in the metabolic chamber (OTHER).
Who is sponsoring clinical trial NCT06340321?
This trial is sponsored by Pennington Biomedical Research Center, which has 258 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06340321 being conducted?
This trial has 1 study location across Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT06340321's enrollment target sits among peer trials
18 982nd of 1053 higher than 64 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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