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NCT06340321 · ClinicalTrials.gov registry record
Impact of Metabolic Flexibility on Changes in Metabolic Health
A clinical trial of Obesity and Metabolic Syndrome, sponsored by Pennington Biomedical Research Center.
- Completed
- Registry status
- 18
- Enrollment target
- 1
- Study location
NCT06340321 is a study of Obesity and Metabolic Syndrome that has completed, run by Pennington Biomedical Research Center. The registered enrollment target is 18 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06340321, a study of Obesity and Metabolic Syndrome, has completed, sponsored by Pennington Biomedical Research Center.
- COMPLETED
- Registry status
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands. Thus, for example, increases in glucose availability after a meal would increase glucose oxidation, while increases in lipid availability during fasting would increase lipid oxidation. Enhanced metabolic flexibility has been proposed to protect humans from metabolic diseases. Nevertheless, most studies examining associations between metabolic flexibility and metabolic health outcomes have used cross-sectional designs. Whether impaired metabolic flexibility causes or results from metabolic health impairment is thus unclear. In this study, the investigators will use the data from a study conducted approximately 16 years ago in healthy participants without obesity. Using the data already collected in that study, the metabolic flexibility of each participant will be calculated. To test the association between metabolic flexibility and the change in metabolic health, the investigators will call back all the participants for a single follow-up visit to reassess several metabolic health outcomes. Thus, the main aim of the study is to test the association between metabolic flexibility and the change in metabolic health outcomes after 16 years in humans.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Metabolic flexibility in the fasted state
- OTHER Metabolic flexibility in euglycemic-hyperinsulinemic clamp
- OTHER Metabolic flexibility in the metabolic chamber
Study Locations (1)
Louisiana
- Pennington Biomedical Research Center - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2024-10-09 |
| Est. Completion | 2025-08-27 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06340321
The ClinicalTrials.gov registry entry for NCT06340321 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The listed sponsor is Pennington Biomedical Research Center, which has 258 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 3 interventions - of which Metabolic flexibility in the fasted state is the first listed.
NCT06340321 reports 1 study location spanning 1 distinct geographic area - top geographies include Louisiana.
Frequently Asked Questions
What is clinical trial NCT06340321 about?
NCT06340321 is a clinical study titled "Impact of Metabolic Flexibility on Changes in Metabolic Health". Metabolic flexibility is the capacity to adapt fuel oxidation to fuel availability so that ATP synthesis can match its cellular demands. Thus, for example, increases in glucose availability after a meal would increase glucose oxidation, while increases in lipid availability during fasting would incr...
What is the current status of trial NCT06340321?
This trial is currently completed. The enrollment target is 18 participants. The study started on 2024-10-09. Estimated completion is 2025-08-27.
What conditions does trial NCT06340321 study?
This clinical trial studies the following conditions: Obesity, Metabolic Syndrome.
What interventions are being tested in trial NCT06340321?
The interventions under investigation include: Metabolic flexibility in the fasted state (DIAGNOSTIC_TEST), Metabolic flexibility in euglycemic-hyperinsulinemic clamp (OTHER), Metabolic flexibility in the metabolic chamber (OTHER).
Who is sponsoring clinical trial NCT06340321?
This trial is sponsored by Pennington Biomedical Research Center, which has 258 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06340321 being conducted?
This trial has 1 study location across Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.