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NCT04223531 · ClinicalTrials.gov registry record · NA
The Natriuretic Peptide Response to Saline Infusion
A NA study of Obesity, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT04223531: Completed NA study of Obesity, sponsored by Vanderbilt University Medical Center.
NCT04223531 is a NA study of Obesity that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 18 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04223531, a NA study of Obesity, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objective is to evaluate the overarching hypothesis that obese and black individuals have relatively lower circulating natriuretic peptide levels compared with lean and white individuals. Conventional clinical assays for measurement of circulating natriuretic peptides display substantial overlap, precluding determination of the basis of the relative natriuretic peptide deficiency previously observed in these groups. We will study lean or obese, black or white, healthy adult subjects with intravenous (IV) saline infusion as a stimulus for natriuretic peptide production and release. We will measure circulating levels of natriuretic peptide isoforms using mass spectrometry that allows the specific identification of proBNP 1-108 and its cleavage product BNP 1-32.
Primary Outcome
proBNP 1-108 is a protein made by the heart. The change in circulating levels will be measured in response to saline infusion
Conditions Studied
Interventions
- DRUG Normal Saline 0.9% Infusion Solution Bag
Study Locations (1)
Tennessee
- Vanderbilt Univeristy - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2020-10-26 |
| Est. Completion | 2022-06-17 |
| Phase | NA |
What the finished NCT04223531 record still lists
NCT04223531 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which Normal Saline 0.9% Infusion Solution Bag is the first listed.
NCT04223531 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT04223531 about?
NCT04223531 is a clinical study titled "The Natriuretic Peptide Response to Saline Infusion". The primary objective is to evaluate the overarching hypothesis that obese and black individuals have relatively lower circulating natriuretic peptide levels compared with lean and white individuals. Conventional clinical assays for measurement of circulating natriuretic peptides display substantial...
What is the current status of trial NCT04223531?
This trial is currently completed. It is a NA study. The enrollment target is 18 participants. The study started on 2020-10-26. Estimated completion is 2022-06-17.
What conditions does trial NCT04223531 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT04223531?
The interventions under investigation include: Normal Saline 0.9% Infusion Solution Bag (DRUG).
Who is sponsoring clinical trial NCT04223531?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04223531 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04223531's enrollment target sits among peer trials
18 982nd of 1053 higher than 64 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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