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NCT01494025 · ClinicalTrials.gov registry record · NA
Identification of Muscle-specific Biomarkers of Fatty Acid Beta-oxidation
A NA study of Obesity, sponsored by USDA, Western Human Nutrition Research Center.
- Completed
- Registry status
- NA
- Development phase
- 13
- Enrollment target
- 1
- Study location
NCT01494025 is a NA study of Obesity that has completed, run by USDA, Western Human Nutrition Research Center. The registered enrollment target is 13 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01494025, a NA study of Obesity, has completed, sponsored by USDA, Western Human Nutrition Research Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 13 participants
- Enrollment target
- 1
- Study location
Study Summary
Elevated fat levels within skeletal muscle cells (intramyocellular lipids) are highly correlated with muscle and whole-body insulin resistance, and more prevalent in obesity. The molecular links and metabolic shifts driving this association remain open to debate, but notably, reduced muscle mitochondrial fatty acid (FA) ß-oxidation is more prevalent among insulin-resistant/diabetic persons. Therefore, discovery of biomarkers reflective of the status of an individual's muscle FA ß-oxidation activity or capacity would have tremendous prognostic and diagnostic value in terms of diabetes. Furthermore, characterization of metabolites associated with muscle mitochondrial fat metabolism should uncover candidate signaling factors which tie FA ß-oxidation to insulin signaling. The investigators propose to identify, for the first time, specific biomarkers of muscle FA ß-oxidation using multiple metabolomic analytical platforms to compare metabolite profiles in samples derived from biological systems displaying disparate muscle fat combustion. The current experiment will test whether plasma metabolites and/or metabolite signatures that track efficient muscular FA ß-oxidation can be experimentally increased in obese, insulin-resistant subjects via a diet-exercise regimen designed to improve muscle fitness and FA combustion.
Conditions Studied
Interventions
- BEHAVIORAL Diet and Exercise
Study Locations (1)
California
- Western Human Nutrition Research Center - Davis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2009-10 |
| Est. Completion | 2012-07 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01494025
The ClinicalTrials.gov registry entry for NCT01494025 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 13 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (98% lower). The listed sponsor is USDA, Western Human Nutrition Research Center, which has 47 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which Diet and Exercise is the first listed.
NCT01494025 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT01494025 about?
NCT01494025 is a clinical study titled "Identification of Muscle-specific Biomarkers of Fatty Acid Beta-oxidation". Elevated fat levels within skeletal muscle cells (intramyocellular lipids) are highly correlated with muscle and whole-body insulin resistance, and more prevalent in obesity. The molecular links and metabolic shifts driving this association remain open to debate, but notably, reduced muscle mitochon...
What is the current status of trial NCT01494025?
This trial is currently completed. It is a NA study. The enrollment target is 13 participants. The study started on 2009-10. Estimated completion is 2012-07.
What conditions does trial NCT01494025 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT01494025?
The interventions under investigation include: Diet and Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT01494025?
This trial is sponsored by USDA, Western Human Nutrition Research Center, which has 47 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01494025 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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