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NCT05713370 · ClinicalTrials.gov registry record · NA
Sleep Restriction and Postprandial Lipemia
A NA study of Obesity and Sleep Deprivation, sponsored by University of Missouri-Columbia.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 2
- Study locations
NCT05713370 is a NA study of Obesity and Sleep Deprivation that has completed, run by University of Missouri-Columbia. The registered enrollment target is 10 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT05713370, a NA study of Obesity and Sleep Deprivation, has completed, sponsored by University of Missouri-Columbia.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 2
- Study locations
Study Summary
Sleep restriction increases overnight and early morning non-esterified fatty acids (NEFA) levels, which are correlated with whole-body decreases in insulin sensitivity, consistent with the observed impairment of intracellular insulin signaling. Adipose tissue biopsies from sleep restricted subjects that are insulin stimulated have reduced phosphorylation of protein kinase B (pAKT). This protein is involved in suppression of intracellular lipolysis and NEFA release. Aerobic exercise has beneficial effects on postprandial lipemia and insulinemia in normal-weight and obese individuals. Acute moderate-intensity aerobic exercise (30-90 min) performed 12-18 h before an oral fat tolerance test or mixed meal test reduces postprandial triglycerides (TG) and insulin concentrations. This response is largely dependent upon the exercise-induced energy deficit as the response is abolished when the calories expended during exercise are replaced. However, it is not known if sleep restriction will interfere with the beneficial effects of prior exercise on postprandial lipemia. The aim of this project is to investigate if sleep restriction negates the positive effect that exercise has on postprandial lipemia. It is hypothesized that sleep restriction will negate the beneficial effects of prior exercise on postprandial lipemia. Additionally sleep restriction will result in a worsening of the lipid profile compared to no exercise. For the proposed study, the investigators will use a repeated measures analysis of variance (ANOVA) (4 study conditions (no exercise+ sleep restriction, no exercise+normal sleep, exercise+normal sleep, exercise+sleep restriction) x time will be used to analyze changes in NEFA and TG concentrations while a one way ANOVA will be used to analyze area under the curve of the NEFA and TG concentrations.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT high fat meal
Study Locations (2)
Missouri
- University of Misouri - Columbia
- University of Missouri - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-07-01 |
| Est. Completion | 2023-12-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05713370
The ClinicalTrials.gov registry entry for NCT05713370 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (99% lower). The listed sponsor is University of Missouri-Columbia, which has 291 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which high fat meal is the first listed.
NCT05713370 reports 2 study locations spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT05713370 about?
NCT05713370 is a clinical study titled "Sleep Restriction and Postprandial Lipemia". Sleep restriction increases overnight and early morning non-esterified fatty acids (NEFA) levels, which are correlated with whole-body decreases in insulin sensitivity, consistent with the observed impairment of intracellular insulin signaling. Adipose tissue biopsies from sleep restricted subjects ...
What is the current status of trial NCT05713370?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2022-07-01. Estimated completion is 2023-12-01.
What conditions does trial NCT05713370 study?
This clinical trial studies the following conditions: Obesity, Sleep Deprivation.
What interventions are being tested in trial NCT05713370?
The interventions under investigation include: high fat meal (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT05713370?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05713370 being conducted?
This trial has 2 study locations across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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