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ClinicalTrials.gov 38 recruiting now early-phase tilt

Neuroblastoma: early-phase trial registry

38 of 98 indexed Neuroblastoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #141 of 28,707 conditions by registered trial count.

98 US clinical trials · 38 currently recruiting · #141 of 28,707 conditions by registered trial count

Neuroblastoma: 98 US clinical trials tracked, 38 recruiting.

Neuroblastoma is the subject of 98 registered US clinical trials on ClinicalTrials.gov, 38 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 78 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 19 of these trials.

Enrollment posture brief

Registry condition neuroblastoma

OPEN 38 | RECR 39% | LATE 6 | EARLY 78 | RANK #141 | SPON 19

Nearest open-share peer: Metastatic Urothelial Carcinoma (39% recruiting · 31 trials)

Pregnancy Related56%Prostate Adenocarcinoma45%Neuroblastoma (this)39%Breast Neoplasms35.7%Colon Cancer34.3%
Open-enrollment share among volume-matched conditions near Neuroblastoma

Neuroblastoma lists 38 open slots (39% of 98 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Neuroblastoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Neuroblastoma recruits in line with its size-band peers.

    38 of 98 indexed trials (38.8%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Neuroblastoma research.

    Memorial Sloan Kettering Cancer Center accounts for 19 of 98 trials (19.4%). 41 distinct sponsors appear on at least one study for this condition label.

  3. Most Neuroblastoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 45 among the 95 trials that report a genuine target (sentinel values excluded). 66 of those (69.5%) plan for fewer than 100 participants.

  4. Neuroblastoma research is mostly interventional.

    89 interventional and 9 observational studies make up this index (90.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 148Phase 230Phase 36

Open and recent trials

98 total, page 2 of 2

ACTIVE NOT RECRUITING Early Phase 1 26 participants

A Study of N9 Chemotherapy in Children With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT04947501

ACTIVE NOT RECRUITING Phase 1 26 participants

iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma

Baylor College of Medicine

NCT01953900

ACTIVE NOT RECRUITING Phase 1 24 participants

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

University of Florida

NCT04837547

ACTIVE NOT RECRUITING Early Phase 1 20 participants

An Investigational Scan (68Ga-DOTATATE PET/CT) in Diagnosing Pediatric Metastatic Neuroendocrine Tumors

Mayo Clinic

NCT04040088

ACTIVE NOT RECRUITING Phase 1 18 participants

Sorafenib and Cyclophosphamide/Topotecan in Patients With Relapsed and Refractory Neuroblastoma

New Approaches to Neuroblastoma Therapy Consortium

NCT02298348

ACTIVE NOT RECRUITING Phase 1 13 participants

Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells

New Approaches to Neuroblastoma Therapy Consortium

NCT02573896

ACTIVE NOT RECRUITING Early Phase 1 13 participants

18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

St. Jude Children's Research Hospital

NCT03541720

ACTIVE NOT RECRUITING Phase 1 11 participants

Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma

Baylor College of Medicine

NCT01192555

ACTIVE NOT RECRUITING Phase 1 11 participants

3rd Generation GD-2 Chimeric Antigen Receptor and ICaspase Suicide Safety Switch, Neuroblastoma, GRAIN

Baylor College of Medicine

NCT01822652

ACTIVE NOT RECRUITING Phase 1 11 participants

Rapid Administration Pilot for Infusing Dinutuximab

Children's Hospital Los Angeles

NCT05421897

ACTIVE NOT RECRUITING NA 7 participants

PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study

Memorial Sloan Kettering Cancer Center

NCT02307630

COMPLETED Phase 3 968 participants

Surgery in Treating Children With Neuroblastoma

Children's Oncology Group

NCT00003119

COMPLETED Phase 3 464 participants

Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma

Children's Oncology Group

NCT00499616

COMPLETED Phase 3 198 participants

A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families

Tufts Medical Center

NCT00782145

COMPLETED Phase 2 164 participants

131 I-MIBG in Treating Patients With Refractory or Relapsed Neuroblastoma

University of California, San Francisco

NCT00293319

COMPLETED Phase 2 140 participants

Preventative Trial of Difluoromethylornithine (DFMO) in High Risk Patients With Neuroblastoma That is in Remission

Giselle Sholler

NCT02395666

COMPLETED Phase 2 122 participants

Impact of Ga-68 DOTATOC PET-CT Imaging in Management of Neuroendocrine Tumors

Sue O'Dorisio

NCT02441062

COMPLETED 121 participants

Prevalence+Significance of Paraneoplastic Autoantibodies in Many Cancers

Memorial Sloan Kettering Cancer Center

NCT00608452

COMPLETED 101 participants

iCAT for Recurrent/Refractory/HR Solid Tumors

Dana-Farber Cancer Institute

NCT01853345

COMPLETED Phase 2 90 participants

New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

National Cancer Institute (NCI)

NCT00001335

COMPLETED Early Phase 1 78 participants

Local Control With Reduced-dose Radiotherapy for High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT02245997

COMPLETED NA 69 participants

Anti-GD2 3F8 Monoclonal Antibody and GM-CSF for High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT02100930

COMPLETED Phase 2 68 participants

Comparative Study of Sensitivity of Ga-DOTATOC PET vs Octreoscan SPECT + CT

Sue O'Dorisio

NCT01869725

COMPLETED Phase 1 54 participants

Study of MLN8237 in Combination With Irinotecan and Temozolomide

New Approaches to Neuroblastoma Therapy Consortium

NCT01601535

COMPLETED Phase 2 53 participants

Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT00410657

COMPLETED Phase 1 40 participants

Recombinant Human Thrombopoietin in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy

St. Jude Children's Research Hospital

NCT00187109

COMPLETED Phase 2 39 participants

3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT01183429

COMPLETED Phase 2 39 participants

hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory Neuroblastoma

Children's Oncology Group

NCT00082758

COMPLETED Phase 2 34 participants

Campath-1H + FK506 and Methylprednisolone for GVHD

Case Comprehensive Cancer Center

NCT00109993

COMPLETED Phase 1 31 participants

N99-02: Melphalan and Buthionine Sulfoximine

New Approaches to Neuroblastoma Therapy Consortium

NCT00005835

COMPLETED Phase 2 30 participants

Rebeccamycin Analog in Treating Children With Relapsed or Refractory Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT00003737

COMPLETED Phase 1 30 participants

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced Neuroblastoma

Children's Oncology Group

NCT00002740

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED Phase 1 21 participants

Safety Study for Refractory or Relapsed Neuroblastoma With DFMO Alone and in Combination With Etoposide

Giselle Sholler

NCT01059071

COMPLETED Phase 1 21 participants

Zoledronic Acid (ZOMETA) With Cyclophosphamide With Neuroblastoma and Cortical Bone Involvement

Baylor College of Medicine

NCT00206388

COMPLETED Phase 1 19 participants

Blood T-Cells and EBV Specific CTLs Expressing GD-2 Specific Chimeric T Cell Receptors to Neuroblastoma Patients

Baylor College of Medicine

NCT00085930

COMPLETED Phase 1 19 participants

Decitabine Followed by a Cancer Antigen Vaccine for Patients With Neuroblastoma and Sarcoma

University of Louisville

NCT01241162

COMPLETED Phase 1 18 participants

HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors

Timothy Cripe

NCT00931931

COMPLETED Phase 1 17 participants

N2004-03: Intravenous Fenretinide in Treating Young Patients With Recurrent or Resistant Neuroblastoma

Nant Operations Center

NCT00646230

COMPLETED Phase 1 15 participants

A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors

National Cancer Institute (NCI)

NCT02107963

COMPLETED Phase 1 13 participants

Neuroblastoma Vaccine for Treatment of High-Risk Neuroblastoma After Chemotherapy

Malcolm Brenner

NCT00048386

COMPLETED Phase 2 9 participants

Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in Patients With Relapsed/Refractory Ewing's Sarcoma and Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT01492673

COMPLETED Phase 1 9 participants

Using Gene Modified Neuroblastoma Cells for the Treatment of Relapsed/Refractory Neuroblastoma

Baylor College of Medicine

NCT00062855

COMPLETED Phase 2 4 participants

High-Dose 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Myeloablative Therapy and Autologous Stem-Cell Transplantation

Memorial Sloan Kettering Cancer Center

NCT01183416

COMPLETED Phase 2 3 participants

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Roswell Park Cancer Institute

NCT00003661

COMPLETED Phase 1

Chemotherapy in Treating Children With Neuroblastoma

New Approaches to Neuroblastoma Therapy Consortium

NCT00002730

COMPLETED Phase 1

Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation

National Institutes of Health Clinical Center (CC)

NCT00064311

COMPLETED Phase 1

Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors

Indiana University School of Medicine

NCT00003107

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Phase Distribution

PhaseTrial count
Phase 1 48
Phase 2 30
Phase 3 6

Named interventions

Most-linked intervention names on Neuroblastoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Cyclophosphamide Drug
10 trials
Temozolomide Drug
7 trials
Topotecan Drug
6 trials
Irinotecan Drug
5 trials
cyclophosphamide Drug
4 trials
Biospecimen Collection Procedure
4 trials
Carboplatin Drug
4 trials
doxorubicin hydrochloride Drug
3 trials

US sites by state

Facility locations filed on Neuroblastoma trials. A trial with sites in several states counts in each.

California 37 trials
New York 30 trials
Texas 28 trials
Pennsylvania 23 trials
Ohio 21 trials
Massachusetts 19 trials
Florida 19 trials
Georgia 18 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Neuroblastoma page

98 registered trials, 38 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Neuroblastoma condition card totals 98 registered trials; most-linked intervention Cyclophosphamide; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.