Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Prostate Adenocarcinoma

Open-data reference.

100 US clinical trials · 45 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 2,050 participants

Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial

NRG Oncology

NCT05050084

RECRUITING Phase 3 1,209 participants

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

NRG Oncology

NCT05946213

RECRUITING 1,000 participants

Customized TULSA-PRO Ablation Registry

Profound Medical

NCT05001477

RECRUITING Phase 3 804 participants

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

ECOG-ACRIN Cancer Research Group

NCT04423211

RECRUITING Phase 3 586 participants

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

NRG Oncology

NCT04134260

RECRUITING NA 500 participants

Reduction of Gastrointestinal Toxicity in Prostate Cancer by Proton Spot Placement

Covenant Health Cancer Center

NCT06200259

RECRUITING Phase 1 470 participants

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

SystImmune

NCT05983432

RECRUITING Phase 3 439 participants

Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer

Curium US

NCT06235151

RECRUITING Early Phase 1 400 participants

Impact of Intraoperative ICG on Functional Outc in RARP

University of California, Irvine

NCT06446648

RECRUITING NA 276 participants

Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound

Case Comprehensive Cancer Center

NCT05610852

RECRUITING Phase 2 194 participants

Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study

NRG Oncology

NCT05053152

RECRUITING NA 180 participants

MRI Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

University of Chicago

NCT05710380

RECRUITING Phase 2 138 participants

Intermittent Fasting Using a Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes

Stephen Freedland

NCT05832086

RECRUITING 120 participants

ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

Duke University

NCT06141993

RECRUITING Phase 2 120 participants

Diagnostic Utility of rhPSMA-7.3 (18F) PET/CT in Men With Prostate Cancer on Active Surveillance

Icahn School of Medicine at Mount Sinai

NCT07285057

RECRUITING Phase 2 110 participants

Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment of Prostate Cancer

Mayo Clinic

NCT06369610

RECRUITING Phase 2 102 participants

Extremely Hypofractionated Intensity Modulated Stereotactic Body Radiotherapy for the Treatment of Prostate Cancer With Rising PSA After Radical Prostatectomy

Jonsson Comprehensive Cancer Center

NCT04915508

RECRUITING Phase 2 100 participants

Prostate Specific Membrane Antigen (PSMA) or (FACBC) PET/CT Site-Directed Therapy for Treatment of Prostate Cancer, Flu-BLAST-PC Study

University of Washington

NCT04175431

RECRUITING Phase 2 95 participants

Hormone Therapy (Apalutamide) and Image-guided Stereotactic Body Radiation Therapy for the Treatment of Patients With Prostate Cancer, HEATWAVE Trial

Jonsson Comprehensive Cancer Center

NCT06067269

RECRUITING Phase 2 90 participants

A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer

University of Chicago

NCT05726292

RECRUITING Phase 2 90 participants

Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

National Cancer Institute (NCI)

NCT06022822

RECRUITING Phase 4 80 participants

Evaluation of the Change in PSMA Expression in Prostate Cancer in Response to Hormonal Therapy

OHSU Knight Cancer Institute

NCT05919329

RECRUITING 77 participants

Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Prostate Cancer (CaP)

Mayo Clinic

NCT06470750

RECRUITING Phase 2 70 participants

Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer

Ohio State University Comprehensive Cancer Center

NCT06330805

RECRUITING Phase 2 68 participants

Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy

David Oh

NCT03821246

RECRUITING Phase 2 60 participants

Hyperpolarized Pyruvate (13C) MR Imaging in Monitoring Patients With Prostate Cancer on Active Surveillance

University of California, San Francis

NCT03933670

RECRUITING Phase 2 60 participants

Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

Shehzad Basaria, M.D.

NCT06957691

RECRUITING Phase 2 60 participants

EBRT and HDR Brachytherapy for Unfavorable-intermediate, High, and Very High-risk Prostate Cancer

University of Virginia

NCT04465500

RECRUITING Phase 1 56 participants

Enzalutamide Implants (Enolen) in Patients With Prostate Cancer

Alessa Therapeutics

NCT06257693

RECRUITING Phase 2 54 participants

Neoadjuvant Lu-177-PSMA-617 in Patients With High Risk Localized Prostate Cancer Undergoing Radical Prostatectomy

Hackensack Meridian Health

NCT06798558

RECRUITING NA 52 participants

High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for the Treatment of Prostate Adenocarcinoma

Jonsson Comprehensive Cancer Center

NCT04945642

RECRUITING Phase 2 50 participants

Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial

Northwestern University

NCT06499870

RECRUITING NA 50 participants

Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors

Roswell Park Cancer Institute

NCT03880422

RECRUITING Phase 2 47 participants

Bipolar Androgen Therapy (BAT) and Radium-223 (RAD) in Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04704505

RECRUITING Phase 2 44 participants

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

SWOG Cancer Research Network

NCT05806515

RECRUITING Phase 2 42 participants

Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor

National Cancer Institute (NCI)

NCT05616650

RECRUITING Early Phase 1 40 participants

rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance

Northwestern University

NCT05852041

RECRUITING Phase 2 34 participants

PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

University of Miami

NCT06392295

RECRUITING Phase 2 30 participants

Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial

Mayo Clinic

NCT07025369

RECRUITING Early Phase 1 27 participants

An Investigational Scan (rhPSMA-7.3 PET/CT) for Detecting Biochemically Recurrent Prostate Cancer, ENLIGHTEN Trial

Northwestern University

NCT06813898

RECRUITING Phase 1 20 participants

PSMA PET Response Guided SabR in High Risk Pca

University of Texas Southwestern Medical Center

NCT06044857

RECRUITING Phase 1 18 participants

Hypofractionated Accelerated Pelvic Nodal Radiotherapy (GCC 2048)

University of Maryland, Baltimore

NCT04486755

RECRUITING NA 17 participants

Two-fraction HDR Monotherapy for Localized Prostate Cancer

University of California, San Francis

NCT05665738

RECRUITING NA 10 participants

The Use of Ultrasound in Assessing Post-prostatectomy Erectile Dysfunction

Mayo Clinic

NCT05109208

RECRUITING Phase 1 8 participants

A Phase I Trial of 61Cu-NODAGA-PSMA for Patients with Prostate Cancer

Hoag Memorial Hospital Presbyterian

NCT06736054

ACTIVE NOT RECRUITING Phase 3 2,753 participants

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

NRG Oncology

NCT04513717

ACTIVE NOT RECRUITING Phase 2 1,171 participants

PSMA PET Imaging of Recurrent Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT03204123

ACTIVE NOT RECRUITING Phase 3 575 participants

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

Exelixis

NCT04446117

ACTIVE NOT RECRUITING Phase 2 310 participants

Finite Androgen Ablation With or Without Abiraterone Acetate and Prednisone in Treating Patients With Recurrent Prostate Cancer

M.D. Anderson Cancer Center

NCT01786265

ACTIVE NOT RECRUITING 303 participants

Mild Hypofractionation With Proton Therapy or IMRT for Intermediate-Risk Prostate Cancer

Abramson Cancer Center at Penn Medicine

NCT01352429

ACTIVE NOT RECRUITING NA 208 participants

Germline DNA-Based Radiosensitivity Biomarker Influence on Toxicity Following Prostate Radiotherapy, GARUDA Trial

Jonsson Comprehensive Cancer Center

NCT04624256

ACTIVE NOT RECRUITING NA 201 participants

A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer

Profound Medical

NCT05027477

ACTIVE NOT RECRUITING 179 participants

CT-guided Stereotactic Body Radiation Therapy and MRI-guided Stereotactic Body Radiation Therapy for Prostate Cancer, MIRAGE Study

Jonsson Comprehensive Cancer Center

NCT04384770

ACTIVE NOT RECRUITING NA 146 participants

High-Dose Brachytherapy in Treating Patients With Prostate Cancer

Stanford University

NCT02346253

ACTIVE NOT RECRUITING Phase 2 141 participants

An Investigational Scan (68Ga-PSMA-11 PET) for the Imaging of Prostate Cancer

University of Washington

NCT04777071

ACTIVE NOT RECRUITING Phase 2 140 participants

Fluciclovine F18 or Ga68-PSMA PET/CT to Enhance Prostate Cancer Outcomes

Emory University

NCT03762759

ACTIVE NOT RECRUITING Phase 2 133 participants

White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA

City of Hope Medical Center

NCT04519879

ACTIVE NOT RECRUITING 130 participants

Development and Evaluation of a Quantitative HP MRI for Clinical Prostate Cancer Exam

M.D. Anderson Cancer Center

NCT04286386

ACTIVE NOT RECRUITING Phase 2 115 participants

Clinical Trial of Green Tea Catechins in Men on Active Surveillance

H. Lee Moffitt Cancer Center and Research Institute

NCT04300855

ACTIVE NOT RECRUITING NA 100 participants

CyberKnife Dose Escalation Prostate Cancer Trial

Crozer-Keystone Health System

NCT03822494

ACTIVE NOT RECRUITING Phase 2 93 participants

177-Lutetium-PSMA Before Stereotactic Body Radiotherapy for the Treatment of Oligorecurrent Prostate Cancer, The LUNAR Study

Jonsson Comprehensive Cancer Center

NCT05496959

ACTIVE NOT RECRUITING 92 participants

Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy

Mayo Clinic

NCT01953640

ACTIVE NOT RECRUITING Phase 2 84 participants

A Study to Evaluate Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer

Mayo Clinic

NCT04190446

ACTIVE NOT RECRUITING Phase 2 60 participants

Abiraterone Acetate, Prednisone, and Apalutamide in Treating Patients With Hormone-Naive Metastatic Prostate Cancer

M.D. Anderson Cancer Center

NCT03821792

ACTIVE NOT RECRUITING Phase 2 60 participants

Nivolumab + Docetaxel + ADT in mHSPC Patients With DDRD or Inflamed Tumors

Xiao X. Wei, MD

NCT04126070

ACTIVE NOT RECRUITING 58 participants

Prostate-Specific Membrane Antigen (PSMA) PET Scans in People Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT04030338

ACTIVE NOT RECRUITING Phase 2 45 participants

Apalutamide in Treating Patients With Prostate Cancer Before Radical Prostatectomy

M.D. Anderson Cancer Center

NCT03412396

ACTIVE NOT RECRUITING Phase 2 44 participants

Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer

Andrew McDonald

NCT04743934

ACTIVE NOT RECRUITING Phase 2 40 participants

A Trial of Androgen Deprivation, Docetaxel, and Enzalutamide for Metastatic Prostate Cancer

Wake Forest University Health Sciences

NCT03246347

ACTIVE NOT RECRUITING NA 37 participants

MRI-Mapped Dose-Escalated Salvage Radiotherapy Post-Prostatectomy: The MAPS Trial

University of Miami

NCT01411345

ACTIVE NOT RECRUITING Phase 2 36 participants

A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT05751434

ACTIVE NOT RECRUITING Phase 2 34 participants

Testing the Effects of Low Dose Apalutamide on Prostate-Specific Antigen (PSA) Levels in Men Scheduled for Removal of the Prostate Gland

National Cancer Institute (NCI)

NCT04530552

ACTIVE NOT RECRUITING NA 33 participants

Novel Synthetic T2W MR Imaging and Spin Parameter Mapping Techniques for Screening Prostate Cancer

M.D. Anderson Cancer Center

NCT05055843

ACTIVE NOT RECRUITING Phase 2 25 participants

Radium Ra 223 Dichloride, Hormone Therapy and Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Prostate Cancer

City of Hope Medical Center

NCT03361735

ACTIVE NOT RECRUITING Phase 2 20 participants

Comparison of 18F-rhPSMA-7.3 PET/CT With and Without Furosemide in Biochemical Recurrence of Prostate Cancer

Emory University

NCT05779943

ACTIVE NOT RECRUITING Phase 2 20 participants

Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer

University of Utah

NCT03796767

ACTIVE NOT RECRUITING Phase 1 20 participants

Bicalutamide Implants (Biolen) With Radiation Therapy in Patients With Localized Prostate Cancer

Alessa Therapeutics

NCT04943536

ACTIVE NOT RECRUITING NA 12 participants

Neoadjuvant Dietary Intervention in Intermediate Risk Prostate Cancer

M.D. Anderson Cancer Center

NCT04985565

ACTIVE NOT RECRUITING Phase 2 12 participants

Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery

Roswell Park Cancer Institute

NCT03899987

ACTIVE NOT RECRUITING Early Phase 1 9 participants

Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression

Beth Israel Deaconess Medical Center

NCT05683964

ACTIVE NOT RECRUITING Phase 2 8 participants

Golimumab and Apalutamide for the Treatment of Castration-Resistant Prostate Cancer, TRAMP Study

University of Washington

NCT05960578

ACTIVE NOT RECRUITING Phase 1 6 participants

Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer

Emory University

NCT06105918

COMPLETED Phase 3 1,138 participants

Gallium Ga 68-labeled PSMA-11 PET/CT in Detecting Recurrent Prostate Cancer in Patients After Initial Therapy

Jonsson Comprehensive Cancer Center

NCT02940262

COMPLETED Phase 2 937 participants

68GA-PSMA-11 PET/CT Scan in Impacting Treatment Strategies for Patients With Prostate Cancer

Jonsson Comprehensive Cancer Center

NCT04050215

COMPLETED NA 550 participants

Increasing the Dose of Survivorship Care Planning in Improving Care and Outcomes in Prostate Cancer Survivors Receiving Androgen Deprivation Therapy

NRG Oncology

NCT03860961

COMPLETED NA 400 participants

68Ga-PSMA-11 PET/CT in Imaging Patients With Intermediate or High Risk Prostate Cancer Before Surgery

Jonsson Comprehensive Cancer Center

NCT03368547

COMPLETED Phase 2 300 participants

C11-Sodium Acetate PET/CT Imaging for Metastatic Disease in Intermediate-to-high Risk Prostate Adenocarcinoma

Phoenix Molecular Imaging

NCT01530269

COMPLETED NA 132 participants

Cholecalciferol Supplement in Treating Patients With Localized Prostate Cancer Undergoing Observation

Roswell Park Cancer Institute

NCT00887432

COMPLETED Phase 2 122 participants

68Ga-RM2 PET/MRI in Biochemically Recurrent Prostate Cancer

Andrei Iagaru

NCT02624518

COMPLETED Phase 2 112 participants

Hormone Therapy and Ipilimumab in Treating Patients With Advanced Prostate Cancer

Mayo Clinic

NCT00170157

COMPLETED NA 83 participants

CyberKnife® as Monotherapy or Boost SBRT for Intermediate or High Risk Localized Prostate Cancer

Wake Forest University Health Sciences

NCT01985828

COMPLETED Phase 2 78 participants

Tivantinib in Treating Patients With Metastatic Prostate Cancer

National Cancer Institute (NCI)

NCT01519414

COMPLETED Phase 1 41 participants

Fluorescent Imaging of Nerves With Illuminare-1 During Surgery

Memorial Sloan Kettering Cancer Center

NCT04983862

COMPLETED Phase 2 31 participants

Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer

M.D. Anderson Cancer Center

NCT03204812

COMPLETED Phase 1 29 participants

An Investigational Scan (rh PSMA 7.3 PET/MRI) for the Detection of Recurrent Disease and Aid in Radiotherapy Planning in Biochemically Recurrent Prostate Cancer

M.D. Anderson Cancer Center

NCT04978675

COMPLETED Phase 2 25 participants

Soy Bread Diet in Improving Immune Function in Participants With Prostate Cancer

Ohio State University Comprehensive Cancer Center

NCT03654638

COMPLETED Phase 1 22 participants

Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring

NRG Oncology

NCT04037254

COMPLETED Phase 2 15 participants

Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer

National Cancer Institute (NCI)

NCT01325311

COMPLETED Phase 2 13 participants

Combining EPI-7386 With Enzalutamide and Androgen Deprivation Therapy for Metastatic Hormone-Sensitive Prostate Cancer

Pedro Barata, MD, MSc

NCT06312670

COMPLETED 5 participants

CCRO044: Quality of Life Assessments Associated With a Physician Communication Intervention for Prostate Cancer Patients

University of California, Davis

NCT03780023

Phase Distribution

PhaseTrial count
Early Phase 1 14
Phase 2 50
Phase 3 8
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Prostate Adenocarcinoma Trial Landscape

ClinicalTrials.gov lists 100 US studies indexed under Prostate Adenocarcinoma, and 45 of those are currently open to recruitment — roughly 45% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Prostate Adenocarcinoma shows 9 late-stage studies (Phase 3 and Phase 4 combined) alongside 64 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Prostate Adenocarcinoma is led by Jonsson Comprehensive Cancer Center with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Prostate Adenocarcinoma?

PlainTrial tracks 100 US clinical trials for Prostate Adenocarcinoma, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Prostate Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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