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Colon Cancer
Open-data reference.
99 US clinical trials · 34 currently recruiting
Active & Recent Trials
Integrated Cancer Repository for Cancer Research
University of Nebraska
NCT02012699
Avera Cancer Sequencing and Analytics Protocol (ASAP)
Avera McKennan Hospital & University Health Center
NCT05142033
Genomic Services Research Program
National Human Genome Research Institute (NHGRI)
NCT02595957
Collection of Blood From Patients With Cancer
National Cancer Institute (NCI)
NCT00034216
EXoPERT EMERALD Clinical Study
EXoPERT
NCT07186296
Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)
University of California, San Francis
NCT05056077
Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)
Washington University School of Medicine
NCT06340646
Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies
National Cancer Institute (NCI)
NCT00451022
Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
Memorial Sloan Kettering Cancer Center
NCT00582621
An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer
City of Hope Medical Center
NCT07255729
Adaptive Symptom Self-Management Immunotherapy Study
University of Arizona
NCT05715255
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Cedars-Sinai Medical Center
NCT04907643
Improving Care for Rural Patients With Solid Tumors
University of Colorado, Denver
NCT04916990
Resilience and Equity in Aging, Cancer, and Health (REACH)
Dana-Farber Cancer Institute
NCT04674267
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
A2 Biotherapeutics
NCT06682793
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Case Comprehensive Cancer Center
NCT06263088
A Study of PHN-012 in Patients With Advanced Solid Tumors
Pheon Therapeutics
NCT07127874
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
RasCal Therapeutics
NCT04678648
PrehabPal: A Digital Tool to Help Older Adults Prepare for Cancer Surgery
University of California, San Francis
NCT05520866
A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors
Sapience Therapeutics
NCT05848739
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
ModeX Therapeutics, An OPKO Health Company
NCT06239194
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
National Cancer Institute (NCI)
NCT03190941
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Washington University School of Medicine
NCT04354064
Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation
Memorial Sloan Kettering Cancer Center
NCT04668872
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer
Cartography Biosciences
NCT07321106
A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)
SCRI Development Innovations
NCT07011576
Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer
Rutgers, The State University of New Jersey
NCT05806931
The Phoenix Trial: Phase II Trial of Cemiplimab for the Non-operative Management of Localized dMMR Colon Cancer
M.D. Anderson Cancer Center
NCT05961709
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
Orano Med
NCT05283330
Phase II Trial of Lung Chemoemobolization
City of Hope Medical Center
NCT05672108
Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers
University of Iowa
NCT05239546
Brodalumab in the Treatment of Immune-Related Adverse Events
Brian Henick, MD
NCT06673329
COLON-MD: Colon Cancer Longitudinal Study
Baylor Research Institute
NCT04751448
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Washington University School of Medicine
NCT06904365
Voyage: Real-World Impact of the Multi-target Stool DNA Test on CRC Screening and Mortality
Exact Sciences Corporation
NCT04124406
Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
Memorial Sloan Kettering Cancer Center
NCT00579514
Genomic Structural Variation in Cancer Susceptibility
Memorial Sloan Kettering Cancer Center
NCT00996710
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
Eli Lilly and Company
NCT03157128
Developing a Virtual Stress Management Intervention for Spousal/Partnered Caregivers of Solid Tumor Cancer Patients.
University of Colorado, Denver
NCT04739696
Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention
M.D. Anderson Cancer Center
NCT05677048
CRC Detection Reliable Assessment With Blood
New Day Diagnostics
NCT05551052
A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)
AstraZeneca
NCT00600496
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
Compugen
NCT04354246
RCT of Mobile Apps & FitBit v. Usual Care
Weill Medical College of Cornell University
NCT03623464
A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Sensei Biotherapeutics
NCT05864144
Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
Emory University
NCT04780477
The Exercise And Colorectal Cancer Treatment Trial
Pennington Biomedical Research Center
NCT03975491
Improving Quality of Life for Colon Cancer Patients and Their Caregivers
University of Hawaii
NCT04713007
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
National Cancer Institute (NCI)
NCT04708470
Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients
The University of Texas Health Science Center at San Antonio
NCT02891538
A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors
Memorial Sloan Kettering Cancer Center
NCT03432806
CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab
Anup Kasi
NCT05121038
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
University of Colorado, Denver
NCT04963283
A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
HUYABIO International
NCT05485974
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
Immunophotonics
NCT05688280
Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal Cancer
M.D. Anderson Cancer Center
NCT05722327
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
City of Hope Medical Center
NCT02293954
Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors
Wake Forest University Health Sciences
NCT06340503
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
GlaxoSmithKline
NCT06710847
Oncology Episode Payment Model in Hawaii
University of Pennsylvania
NCT03523546
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
University Hospitals Cleveland Medical Center
NCT00622557
Mailed FIT Outreach 2022
Abramson Cancer Center at Penn Medicine
NCT05341622
Study of Colorectal Cancer Screening Options
Kaiser Permanente
NCT05987709
Adherence to Colon Cancer Screening (ACCS)
Ohio State University Comprehensive Cancer Center
NCT02112747
Online Study of Colorectal Cancer and Prostate Cancer Screening Decision Making
University of North Carolina, Chapel Hill
NCT01558583
Patient Navigator Project
H. Lee Moffitt Cancer Center and Research Institute
NCT00375024
Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults
Norgine
NCT02254486
Impact of a Novel Patient Educational Booklet on Colonoscopy Quality
VA Greater Los Angeles Healthcare System
NCT00975247
BLI850-302: BLI850 vs an Approved Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy
Braintree Laboratories
NCT00756548
Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer
Wake Forest University Health Sciences
NCT01656044
Men Together Making a Difference: Health Promotion for Black Men
University of Pennsylvania
NCT02572414
Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer
Ohio State University Comprehensive Cancer Center
NCT01801059
Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)
Indiana University
NCT03462706
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma
NCT02632448
Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer
Amgen
NCT00625651
FOcus on Reducing Dose-limiting Toxicities in Colon Cancer With Resistance Exercise Study
Kaiser Permanente
NCT03291951
Reducing VA No-Shows: Evaluation of Predictive Overbooking Applied to Colonoscopy
VA Office of Research and Development
NCT01639443
Prospective Randomized Controlled Trial Comparing Water and Air Colonoscopy in a Community Based Setting
University of California, Davis
NCT01729416
Understanding the Value of Community Vital Signs in Primary Care
Virginia Commonwealth University
NCT02512835
GI SPORE Colon Biosample Protocol
University of Michigan
NCT02243267
Safety of BKM120 Monotherapy in Advanced Solid Tumor Patients
Novartis Pharmaceuticals
NCT01068483
Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients
M.D. Anderson Cancer Center
NCT00508846
Latino Peers as Patient Navigators for Colon Cancer Screening
Icahn School of Medicine at Mount Sinai
NCT02226107
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
Corewell Health West
NCT00467922
Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy
Washington University School of Medicine
NCT05427214
CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer
David Bajor, MD
NCT02861300
Clinical Trial in Patients With Metastatic Colorectal Cancer
Mast Therapeutics
NCT00081627
Promoting Physical Activity After Colorectal Cancer
The Miriam Hospital
NCT00230646
Hybrid APC Assisted EMR for Large Colon Polyps
Milton S. Hershey Medical Center
NCT03390907
Sleep Coach: A Mobile App to Address Insomnia Symptoms Among Cancer Survivors
University of Michigan Rogel Cancer Center
NCT04827459
Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy
UNC Lineberger Comprehensive Cancer Center
NCT01789983
Genetic Investigation of Solid Tumors Cohort
Scripps Translational Science Institute
NCT01005225
Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies
Novita Pharmaceuticals
NCT03199586
Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance
National Human Genome Research Institute (NHGRI)
NCT02767986
Clinical and Translational Study of STA-9090
Memorial Sloan Kettering Cancer Center
NCT01111838
Cellular Immune Augmentation in Colon and Rectal Cancer
University of California, Irvine
NCT00257322
Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer
National Cancer Institute (NCI)
NCT03384316
Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers
National Cancer Institute (NCI)
NCT03801915
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
St. Luke's-Roosevelt Hospital Center
NCT01163552
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 26 |
| Phase 2 | 11 |
| Phase 3 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Colon Cancer Trial Landscape
ClinicalTrials.gov lists 99 US studies indexed under Colon Cancer, and 34 of those are currently open to recruitment — roughly 34% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Colon Cancer shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 37 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Colon Cancer is led by National Cancer Institute (NCI) with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 99 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Colon Cancer?
PlainTrial tracks 99 US clinical trials for Colon Cancer, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Colon Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.