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ClinicalTrials.gov 34 recruiting now official registry

Colon Cancer clinical trials

34 of 99 indexed Colon Cancer trials are currently recruiting.

99 US clinical trials · 34 currently recruiting

Colon Cancer is the subject of 99 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.

The research picture

Colon Cancer has 99 registered US clinical trials, 34 of them open to new participants right now, about 34% of the total.

34
recruiting participants now
34%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
6
top sponsor: National Cancer Institute (NCI)
Phase 126Phase 211Phase 34

Active & Recent Trials

99 total, page 1 of 2

RECRUITING open-ended (no fixed target)

Integrated Cancer Repository for Cancer Research

University of Nebraska

NCT02012699

RECRUITING 25,000 participants

Avera Cancer Sequencing and Analytics Protocol (ASAP)

Avera McKennan Hospital & University Health Center

NCT05142033

RECRUITING 5,000 participants

Genomic Services Research Program

National Human Genome Research Institute (NHGRI)

NCT02595957

RECRUITING 1,750 participants

Collection of Blood From Patients With Cancer

National Cancer Institute (NCI)

NCT00034216

RECRUITING 1,400 participants

EXoPERT EMERALD Clinical Study

EXoPERT

NCT07186296

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francisco

NCT05056077

RECRUITING NA 990 participants

Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

Washington University School of Medicine

NCT06340646

RECRUITING 750 participants

Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies

National Cancer Institute (NCI)

NCT00451022

RECRUITING 500 participants

Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

Memorial Sloan Kettering Cancer Center

NCT00582621

RECRUITING 400 participants

An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer

City of Hope Medical Center

NCT07255729

RECRUITING NA 400 participants

Adaptive Symptom Self-Management Immunotherapy Study

University of Arizona

NCT05715255

RECRUITING NA 360 participants

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Cedars-Sinai Medical Center

NCT04907643

RECRUITING NA 320 participants

Improving Care for Rural Patients With Solid Tumors

University of Colorado, Denver

NCT04916990

RECRUITING NA 257 participants

Resilience and Equity in Aging, Cancer, and Health (REACH)

Dana-Farber Cancer Institute

NCT04674267

RECRUITING Phase 1 240 participants

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06682793

RECRUITING NA 200 participants

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Case Comprehensive Cancer Center

NCT06263088

RECRUITING Phase 1 165 participants

A Study of PHN-012 in Patients With Advanced Solid Tumors

Pheon Therapeutics

NCT07127874

RECRUITING Phase 1 134 participants

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

RasCal Therapeutics

NCT04678648

RECRUITING NA 132 participants

PrehabPal: A Digital Tool to Help Older Adults Prepare for Cancer Surgery

University of California, San Francisco

NCT05520866

RECRUITING Phase 1 130 participants

A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors

Sapience Therapeutics

NCT05848739

RECRUITING Phase 1 115 participants

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

ModeX Therapeutics, An OPKO Health Company

NCT06239194

RECRUITING Phase 1 110 participants

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

National Cancer Institute (NCI)

NCT03190941

RECRUITING 100 participants

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Washington University School of Medicine

NCT04354064

RECRUITING 80 participants

Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation

Memorial Sloan Kettering Cancer Center

NCT04668872

RECRUITING Phase 1 80 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

Cartography Biosciences

NCT07321106

RECRUITING Phase 2 60 participants

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)

SCRI Development Innovations

NCT07011576

RECRUITING Phase 2 50 participants

Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer

Rutgers, The State University of New Jersey

NCT05806931

RECRUITING Phase 2 50 participants

The Phoenix Trial: Phase II Trial of Cemiplimab for the Non-operative Management of Localized dMMR Colon Cancer

M.D. Anderson Cancer Center

NCT05961709

RECRUITING Phase 1 48 participants

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Orano Med

NCT05283330

RECRUITING Phase 2 30 participants

Phase II Trial of Lung Chemoemobolization

City of Hope Medical Center

NCT05672108

RECRUITING Phase 2 25 participants

Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers

University of Iowa

NCT05239546

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

RECRUITING 11 participants

COLON-MD: Colon Cancer Longitudinal Study

Baylor Research Institute

NCT04751448

RECRUITING 10 participants

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Washington University School of Medicine

NCT06904365

ACTIVE NOT RECRUITING 150,000 participants

Voyage: Real-World Impact of the Multi-target Stool DNA Test on CRC Screening and Mortality

Exact Sciences Corporation

NCT04124406

ACTIVE NOT RECRUITING NA 21,081 participants

Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT00579514

ACTIVE NOT RECRUITING 1,275 participants

Genomic Structural Variation in Cancer Susceptibility

Memorial Sloan Kettering Cancer Center

NCT00996710

ACTIVE NOT RECRUITING Phase 1 857 participants

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

Eli Lilly and Company

NCT03157128

ACTIVE NOT RECRUITING NA 510 participants

Developing a Virtual Stress Management Intervention for Spousal/Partnered Caregivers of Solid Tumor Cancer Patients.

University of Colorado, Denver

NCT04739696

ACTIVE NOT RECRUITING NA 205 participants

Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

M.D. Anderson Cancer Center

NCT05677048

ACTIVE NOT RECRUITING 196 participants

CRC Detection Reliable Assessment With Blood

New Day Diagnostics

NCT05551052

ACTIVE NOT RECRUITING Phase 1 140 participants

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

AstraZeneca

NCT00600496

ACTIVE NOT RECRUITING Phase 1 110 participants

COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies

Compugen

NCT04354246

ACTIVE NOT RECRUITING NA 107 participants

RCT of Mobile Apps & FitBit v. Usual Care

Weill Medical College of Cornell University

NCT03623464

ACTIVE NOT RECRUITING Phase 1 98 participants

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Sensei Biotherapeutics

NCT05864144

ACTIVE NOT RECRUITING NA 60 participants

Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer

Emory University

NCT04780477

ACTIVE NOT RECRUITING NA 60 participants

The Exercise And Colorectal Cancer Treatment Trial

Pennington Biomedical Research Center

NCT03975491

ACTIVE NOT RECRUITING NA 60 participants

Improving Quality of Life for Colon Cancer Patients and Their Caregivers

University of Hawaii

NCT04713007

ACTIVE NOT RECRUITING Phase 1 55 participants

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

National Cancer Institute (NCI)

NCT04708470

ACTIVE NOT RECRUITING Early Phase 1 51 participants

Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients

The University of Texas Health Science Center at San Antonio

NCT02891538

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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 11
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Colon Cancer Trial Landscape

99 indexed Colon Cancer studies · 34 recruiting (34%).

Phase mix: 4 late (III/IV) vs 37 early (I/II).

Top sponsor: National Cancer Institute (NCI) (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Colon Cancer?

PlainTrial tracks 99 US clinical trials for Colon Cancer, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Colon Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.