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NCT04837547 · ClinicalTrials.gov registry record · Phase 1
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
A Phase 1 study of Neuroblastoma and Diffuse Intrinsic Pontine Glioma, sponsored by University of Florida.
- Active
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 3
- Study locations
NCT04837547 is a Phase 1 study of Neuroblastoma and Diffuse Intrinsic Pontine Glioma that is active but no longer recruiting, run by University of Florida. The registered enrollment target is 24 participants, below the 239-participant average among 94 other Neuroblastoma trials with a reported enrollment target (90% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT04837547, a Phase 1 study of Neuroblastoma and Diffuse Intrinsic Pontine Glioma, is active but no longer recruiting, sponsored by University of Florida.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 3
- Study locations
Study Summary
A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in combination with adoptive cell therapy (Total tumor mRNA-pulsed autologous Dendritic Cells (DCs) (TTRNA-DCs), Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT) and Autologous G-CSF mobilized Hematopoietic Stem Cells (HSCs)).
Conditions Studied
Interventions
- BIOLOGICAL Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)
Study Locations (3)
Florida
- University of Florida - Gainesville
North Carolina
- Levine Children's Hospital - Charlotte
Pennsylvania
- Penn State Milton S. Hershey Medical Center and Children's Hospital - Hershey
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2021-09-20 |
| Est. Completion | 2032-09 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04837547
The ClinicalTrials.gov registry entry for NCT04837547 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 239-participant average among 94 other Neuroblastoma trials with a reported enrollment target (90% lower). The listed sponsor is University of Florida, which has 1,106 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Neuroblastoma appearing as the primary indexed condition, and to 1 intervention - of which Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT) is the first listed.
NCT04837547 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Florida, North Carolina, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04837547 about?
NCT04837547 is a clinical study titled "PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy". A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in combination with adoptive cell therapy (Total tumor mRNA-pulsed autologous Dendr...
What is the current status of trial NCT04837547?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2021-09-20. Estimated completion is 2032-09.
What conditions does trial NCT04837547 study?
This clinical trial studies the following conditions: Neuroblastoma, Diffuse Intrinsic Pontine Glioma.
What interventions are being tested in trial NCT04837547?
The interventions under investigation include: Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT) (BIOLOGICAL).
Who is sponsoring clinical trial NCT04837547?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04837547 being conducted?
This trial has 3 study locations across Florida, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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