Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

NCT00003661 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Umbilical cord blood transplantation may be able to replace cells destroyed by chemotherapy or radiation therapy. PURPOSE: Phase II trial to study the effectiveness of chemotherapy, radiation therapy, and umbilical cord blood transplantation in treating patients who have hematologic cancer.

Interventions

  • DRUG methylprednisolone
  • DRUG melphalan
  • DRUG busulfan
  • DRUG cyclosporine
  • BIOLOGICAL anti-thymocyte globulin

Study Locations (17)

Florida

  • University of Florida Health Science Center — Gainesville
  • Division of Pediatric Surgery — Jacksonville
  • Nemours Children's Clinic — Jacksonville
  • H. Lee Moffitt Cancer Center and Research Institute — Tampa

New York

  • Roswell Park Cancer Institute — Buffalo
  • North Shore University Hospital — Manhasset
  • New York Blood Center — New York

Illinois

  • Rush-Presbyterian-St. Luke's Medical Center — Chicago
  • University of Chicago Cancer Research Center — Chicago

North Carolina

  • Lineberger Comprehensive Cancer Center, UNC — Chapel Hill
  • Duke Comprehensive Cancer Center — Durham

South Carolina

  • Medical University of South Carolina — Charleston
  • University of South Carolina School of Medicine — Columbia

Louisiana

  • Children's Hospital of New Orleans — New Orleans

Missouri

  • Cardinal Glennon Children's Hospital — St Louis

New Jersey

  • Hackensack University Medical Center — Hackensack

Trial Details

FieldValue
Enrollment Target 3 participants
Start Date 1998-06
Est. Completion 2006-03
Phase Phase 2

Sponsor

Roswell Park Cancer Institute

228 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00003661

The ClinicalTrials.gov registry entry for NCT00003661 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 3 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Roswell Park Cancer Institute, which has 228 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which methylprednisolone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00003661 reports 17 study locations spanning 9 distinct geographic areas — top geographies include Florida, New York, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00003661 about?

NCT00003661 is a clinical study titled "Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer". RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Umbilical cord blood transplantation may be able to replace cells destroyed by chemotherapy or radiation therapy....

What is the current status of trial NCT00003661?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 3 participants. The study started on 1998-06. Estimated completion is 2006-03.

What conditions does trial NCT00003661 study?

This clinical trial studies the following conditions: Lymphoma, Leukemia, Myelodysplastic Syndromes, Neuroblastoma, Graft Versus Host Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00003661?

The interventions under investigation include: methylprednisolone (DRUG), melphalan (DRUG), busulfan (DRUG), cyclosporine (DRUG), anti-thymocyte globulin (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00003661?

This trial is sponsored by Roswell Park Cancer Institute, which has 228 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00003661 being conducted?

This trial has 17 study locations across Florida, Illinois, Louisiana, Missouri, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial