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ACTIVE NOT RECRUITING Phase 1

Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells

NCT02573896 · View on ClinicalTrials.gov ↗

Study Summary

This NANT trial will determine the maximum tolerated dose (MTD) of autologous expanded natural killer (NK) cells when combined with standard dosing of dinutuximab and will assess the feasibility of adding lenalidomide at the recommended Phase II dose of the expanded NK cells with dinutuximab, for treatment of children with refractory or recurrent neuroblastoma.

Conditions Studied

Interventions

  • DRUG Lenalidomide
  • DRUG Dinutuximab
  • BIOLOGICAL NK Cells

Study Locations (11)

California

  • Children's Hospital Los Angeles — Los Angeles
  • UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco

Ohio

  • Cincinnati Children's Hospital Medical Center — Cincinnati
  • Nationwide Children's Hospital — Columbus

Georgia

  • AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus — Atlanta

Illinois

  • University of Chicago Comer Children's Hospital — Chicago

Massachusetts

  • Childrens Hospital Boston, Dana-Farber Cancer Institute. — Boston

Michigan

  • C.S Mott Children's Hospital — Ann Arbor

Pennsylvania

  • Children's Hospital of Philadelphia — Philadelphia

Texas

  • Cook Children's Healthcare System — Fort Worth

Trial Details

FieldValue
Enrollment Target 13 participants
Start Date 2019-01-14
Est. Completion 2026-12
Phase Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02573896

The ClinicalTrials.gov registry entry for NCT02573896 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 13 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is New Approaches to Neuroblastoma Therapy Consortium, which has 39 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neuroblastoma appearing as the primary indexed condition, and to 3 interventions — of which Lenalidomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02573896 reports 11 study locations spanning 9 distinct geographic areas — top geographies include California, Ohio, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02573896 about?

NCT02573896 is a clinical study titled "Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells". This NANT trial will determine the maximum tolerated dose (MTD) of autologous expanded natural killer (NK) cells when combined with standard dosing of dinutuximab and will assess the feasibility of adding lenalidomide at the recommended Phase II dose of the expanded NK cells with dinutuximab, for tr...

What is the current status of trial NCT02573896?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2019-01-14. Estimated completion is 2026-12.

What conditions does trial NCT02573896 study?

This clinical trial studies the following conditions: Neuroblastoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02573896?

The interventions under investigation include: Lenalidomide (DRUG), Dinutuximab (DRUG), NK Cells (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02573896?

This trial is sponsored by New Approaches to Neuroblastoma Therapy Consortium, which has 39 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02573896 being conducted?

This trial has 11 study locations across California, Georgia, Illinois, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial