Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 35 recruiting now official registry

Breast Neoplasms clinical trials

Every US clinical trial registered for Breast Neoplasms — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

98 US clinical trials · 35 currently recruiting

The research picture

Breast Neoplasms has 98 registered US clinical trials, 35 of them open to new participants right now — about 36% of the total.

35
recruiting participants now
36%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
10
top sponsor: Pfizer

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 2 5,000 participants

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

QuantumLeap Healthcare Collaborative

NCT01042379

RECRUITING NA 3,300 participants

Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

UNC Lineberger Comprehensive Cancer Center

NCT07214610

RECRUITING Phase 3 2,400 participants

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Merck Sharp & Dohme

NCT06966700

RECRUITING NA 1,500 participants

Biennial CEM in Women With a Personal History of Breast Cancer

Wendie Berg

NCT06105749

RECRUITING Phase 3 1,200 participants

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

Merck Sharp & Dohme

NCT06312176

RECRUITING Phase 3 1,000 participants

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Merck Sharp & Dohme

NCT07060807

RECRUITING 1,000 participants

Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

Saint John's Cancer Institute

NCT04603209

RECRUITING Phase 3 920 participants

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Eli Lilly and Company

NCT07174336

RECRUITING 800 participants

A Study of Breast Cancer Risk Factors and Outcomes of People in Florida

Memorial Sloan Kettering Cancer Center

NCT06780176

RECRUITING Phase 3 558 participants

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

BioNTech SE

NCT07173751

RECRUITING Phase 3 500 participants

Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ

Uppsala University

NCT04722692

RECRUITING Phase 2 500 participants

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

Bristol-Myers Squibb

NCT06926868

RECRUITING Phase 1 421 participants

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

Eli Lilly and Company

NCT07114601

RECRUITING 420 participants

A Registry Study of Breast Microseed Treatment

Concure Oncology-Breast Microseed

NCT02701244

RECRUITING Phase 2 372 participants

Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

Merck Sharp & Dohme

NCT06797635

RECRUITING 300 participants

Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells

Washington University School of Medicine

NCT00353483

RECRUITING Phase 2 297 participants

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

Kristina A. Fanucci

NCT07222215

RECRUITING Phase 1 241 participants

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

Eli Lilly and Company

NCT07213791

RECRUITING Phase 1 220 participants

Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

Circle Pharma

NCT06577987

RECRUITING Phase 2 172 participants

A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06157892

RECRUITING NA 160 participants

Breast Cancer, Reasoning, and Activity Intervention

Mayo Clinic

NCT04816006

RECRUITING Phase 1 128 participants

A Study of DM001 in Patients With Advanced Solid Tumors

Xadcera Biopharmaceutical (Suzhou) Co.

NCT06475937

RECRUITING Phase 1 100 participants

A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

Pfizer

NCT06966453

RECRUITING Phase 4 100 participants

DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment

Rutgers, The State University of New Jersey

NCT07158164

RECRUITING Phase 2 87 participants

(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer

Atossa Therapeutics

NCT05607004

RECRUITING Phase 1 81 participants

Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

Merck Sharp & Dohme

NCT06686394

RECRUITING Phase 1 73 participants

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Stemline Therapeutics

NCT05386108

RECRUITING Phase 2 60 participants

Preventing Dato-DXd Associated Stomatitis With Dexamethasone Mouthwash, TROPION-DM

Brown University

NCT06974604

RECRUITING Phase 2 50 participants

Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score

Washington University School of Medicine

NCT02476786

RECRUITING Phase 2 48 participants

Tirzepatide Weight Loss for MRD+ Early Breast Cancer

Baylor Research Institute

NCT06517212

RECRUITING Phase 1 32 participants

Focused Ultrasound and Gemcitabine in Breast Cancer

Patrick Dillon, MD

NCT04796220

RECRUITING Phase 2 30 participants

A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

GlaxoSmithKline

NCT04641247

RECRUITING 25 participants

The Intestinal Microbiome in Triple Negative Breast Cancer Treated with Immunotherapy

Pennington Biomedical Research Center

NCT06318507

RECRUITING NA 20 participants

Dissemination of BREASTChoice AIM1-B

UNC Lineberger Comprehensive Cancer Center

NCT07396766

RECRUITING Phase 1 18 participants

A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

Memorial Sloan Kettering Cancer Center

NCT06623396

ACTIVE NOT RECRUITING Phase 3 8,000 participants

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Eli Lilly and Company

NCT05514054

ACTIVE NOT RECRUITING NA 1,647 participants

Tomosynthesis vs. Contrast-Enhanced Mammography in Women With Personal History of Breast Cancer in Western Pennsylvania

Wendie Berg

NCT04085510

ACTIVE NOT RECRUITING 992 participants

Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers

Memorial Sloan Kettering Cancer Center

NCT00579163

ACTIVE NOT RECRUITING Phase 3 927 participants

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

AstraZeneca

NCT05113251

ACTIVE NOT RECRUITING Phase 3 874 participants

A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer

Eli Lilly and Company

NCT04975308

ACTIVE NOT RECRUITING Phase 3 669 participants

A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer

Eli Lilly and Company

NCT02107703

ACTIVE NOT RECRUITING Phase 2 362 participants

Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

Pfizer

NCT04557449

ACTIVE NOT RECRUITING Phase 3 340 participants

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

Merck Sharp & Dohme

NCT04895358

ACTIVE NOT RECRUITING Phase 1 329 participants

Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

BicycleTx Limited

NCT04561362

ACTIVE NOT RECRUITING Phase 3 300 participants

Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation

Alliance for Clinical Trials in Oncology

NCT04711109

ACTIVE NOT RECRUITING Phase 1 268 participants

Phase I/II Study of the Anti-Programmed Death Ligand-1 Durvalumab Antibody (MEDI4736) in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Can...

National Cancer Institute (NCI)

NCT02484404

ACTIVE NOT RECRUITING NA 202 participants

The IDEA Study (Individualized Decisions for Endocrine Therapy Alone)

University of Michigan Rogel Cancer Center

NCT02400190

ACTIVE NOT RECRUITING Phase 1 198 participants

A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread

Eli Lilly and Company

NCT02057133

ACTIVE NOT RECRUITING NA 173 participants

Lifestyle, Exercise, and Nutrition Study Early After Diagnosis

Yale University

NCT03314688

ACTIVE NOT RECRUITING Phase 1 140 participants

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

AstraZeneca

NCT00600496

ACTIVE NOT RECRUITING Phase 1 134 participants

A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations

Atavistik Bio

NCT07038369

ACTIVE NOT RECRUITING 125 participants

Multi-Institutional Transgender & Gender-Diverse Breast Cancer Study

Medical College of Wisconsin

NCT06234488

ACTIVE NOT RECRUITING Phase 2 84 participants

PD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast Cancer

Washington University School of Medicine

NCT01723774

ACTIVE NOT RECRUITING 68 participants

Study of the Safety of MRI Scans in People Who Have Breast Tissue Expanders After Mastectomy

Memorial Sloan Kettering Cancer Center

NCT04769960

ACTIVE NOT RECRUITING Phase 1 44 participants

Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast

Icahn School of Medicine at Mount Sinai

NCT03304080

ACTIVE NOT RECRUITING Phase 2 40 participants

Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer

City of Hope Medical Center

NCT01273610

ACTIVE NOT RECRUITING Phase 1 34 participants

Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer

US Oncology Research

NCT03379428

ACTIVE NOT RECRUITING Phase 1 31 participants

A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer

Eisai

NCT04288089

ACTIVE NOT RECRUITING Phase 2 12 participants

Pembrolizumab, IRX-2, and Chemotherapy in Triple Negative Breast Cancer

Providence Health & Services

NCT04373031

COMPLETED Phase 3 10,000 participants

Raloxifene Use for The Heart

Eli Lilly and Company

NCT00190593

COMPLETED 1,772 participants

A Study to Understand About the Study Medicine Palbociclib in Breast Cancer Patients After it is Out in the Japanese Market

Pfizer

NCT07096024

COMPLETED Phase 3 865 participants

Phase III Study of Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer

Intarcia Therapeutics

NCT00044291

COMPLETED Phase 3 594 participants

Study Of Sunitinib In Combination With Docetaxel Vs Docetaxel In Patients With Advanced Breast Cancer

Pfizer

NCT00393939

COMPLETED Phase 3 488 participants

A Study Of SU011248 Plus Paclitaxel Versus Bevacizumab Plus Paclitaxel In Patients With Advanced Breast Cancer

Pfizer

NCT00373256

COMPLETED Phase 3 444 participants

A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Hoffmann-La Roche

NCT02131064

COMPLETED Phase 3 431 participants

A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study)

Pfizer

NCT01945775

COMPLETED NA 224 participants

A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients

Washington University School of Medicine

NCT00355316

COMPLETED NA 191 participants

Hypnosis to Reduce Aromatase Inhibitor Pain and Improve Adherence

Icahn School of Medicine at Mount Sinai

NCT02657993

COMPLETED Phase 1 174 participants

AG-013736 In Combination With Docetaxel Versus Docetaxel Alone For Patients With Metastatic Breast Cancer

Pfizer

NCT00076024

COMPLETED NA 151 participants

Nuevo Amanecer: Promoting the Psychosocial Health of Latinas

University of California, San Francis

NCT01383174

COMPLETED Phase 1 144 participants

A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer

Hoffmann-La Roche

NCT03280563

COMPLETED Phase 1 133 participants

This Study in Patients With Different Types of Cancer (Solid Tumours) Aims to Find a Safe Dose of Xentuzumab in Combination With Abemaciclib With or Without Hormonal Therapies. The Study Also Tests How Effective These Medicines Are in Patients With Lung and Breast Cancer

Boehringer Ingelheim

NCT03099174

COMPLETED NA 107 participants

Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings

Thomas Jefferson University

NCT03929783

COMPLETED Phase 1 106 participants

A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

Ambrx

NCT03255070

COMPLETED Early Phase 1 100 participants

Testing of Different Methods for Determining Whether Breast Cancer Has Spread to the Lymph Nodes

Washington University School of Medicine

NCT00360152

COMPLETED NA 100 participants

Efficacy Study of an Educational Program for Decision Support for Breast Cancer

Baylor College of Medicine

NCT00473096

COMPLETED Phase 2 90 participants

Study Of The Efficacy And Safety Of SU-014813 In Patients With Metastatic Breast Cancer

Pfizer

NCT00322517

COMPLETED Phase 1 79 participants

Study of Safety and Efficacy of Alpelisib With Everolimus or Alpelisib With Everolimus and Exemestane in Advanced Breast Cancer Patients, Renal Cell Cancer and Pancreatic Tumors

Novartis Pharmaceuticals

NCT02077933

COMPLETED Phase 2 79 participants

Bevacizumab Given With Either Anastrozole or Fulvestrant With Trastuzumab for Postmenopausal Metastatic Breast Cancer

SCRI Development Innovations

NCT00405938

COMPLETED NA 79 participants

Evaluating and Comparing Two Surgical Methods for Treatment of Early Stage Breast Cancer

Emory University

NCT01271738

COMPLETED Early Phase 1 79 participants

Using Hyperpolarized [1-13C]Pyruvate to Detect Cardiotoxicity

University of Texas Southwestern Medical Center

NCT03685175

COMPLETED 78 participants

Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging to Assess Tumor-Associated Vasculature in Patients With Metastatic Breast Cancer

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00071357

COMPLETED Phase 3 65 participants

A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer

National Cancer Institute (NCI)

NCT00001338

COMPLETED Phase 2 60 participants

Phase 2 Study of TLK286 in Metastatic Breast Cancer

Telik

NCT00035841

COMPLETED Phase 1 58 participants

Vaccination of High Risk Breast Cancer Patients

University of Arkansas

NCT02229084

COMPLETED Phase 2 46 participants

Exemestane and Celecoxib in Postmenopausal Women at High Risk for Breast Cancer

Georgetown University

NCT00073073

COMPLETED Phase 1 42 participants

Study of XL147 (SAR245408) in Combination With Trastuzumab or Paclitaxel and Trastuzumab in Subjects With Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab-based Regimen

Sanofi

NCT01042925

COMPLETED Phase 2 41 participants

Enzastaurin For Breast Cancer Patients Who Previously Received an Anthracycline and a Taxane Chemotherapy

Eli Lilly and Company

NCT00386087

COMPLETED NA 40 participants

Know Your Risk: Assessment at Screening for Breast Cancer - Pilot Study

Columbia University

NCT02954900

COMPLETED 33 participants

Treatment Patterns and Clinical Outcomes Among Talazoparib-Treated Adults With HER2-Negative mBC With gBRCA1/2m

Pfizer

NCT05141708

COMPLETED Phase 2 31 participants

PF-3512676 (CPG 7909) Injection For Patients Who Completed An Oncology Study Using PF-3512676 (CPG 7909)

Pfizer

NCT00043368

COMPLETED Phase 2 30 participants

Phase II Study to Evaluate Tariquidar (XR9576), a Selective MDR-1 Inhibitor, in Chemotherapy Resistant Advanced Breast Cancer

QLT

NCT00048633

COMPLETED Phase 2 26 participants

Afatinib (BIBW2992) in HER2 (Human Epidermal Growth Factor Receptor 2)-Overexpressing Inflammatory Breast Cancer

Boehringer Ingelheim

NCT01325428

COMPLETED Phase 1 25 participants

Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer

Pharmacyclics

NCT00120939

COMPLETED 20 participants

Ultrasound Targeting for the Lumpectomy Cavity

University of Iowa

NCT00583843

COMPLETED Phase 1 19 participants

Bright Light on Fatigue in Women Being Treated for Breast Cancer

Washington University School of Medicine

NCT02658708

COMPLETED 13 participants

Studying Normal Breast Tissue and Cancer Risk

National Cancer Institute (NCI)

NCT00341692

COMPLETED Phase 1 9 participants

Evaluating the T Cell Response to a Peptide-based Vaccine in Patients With Breast Cancer

Craig L Slingluff, Jr

NCT00892567

Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 22
Phase 3 19
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Breast Neoplasms Trial Landscape

ClinicalTrials.gov lists 98 US studies indexed under Breast Neoplasms, and 35 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Breast Neoplasms shows 20 late-stage studies (Phase 3 and Phase 4 combined) alongside 51 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Breast Neoplasms is led by Pfizer with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 98 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Breast Neoplasms?

PlainTrial tracks 98 US clinical trials for Breast Neoplasms, of which 35 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Breast Neoplasms?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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