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ClinicalTrials.gov 73 recruiting now official registry

Myelodysplastic Syndromes clinical trials

73 of 193 indexed Myelodysplastic Syndromes trials are currently recruiting.

193 US clinical trials · 73 currently recruiting

Myelodysplastic Syndromes is the subject of 193 registered US clinical trials on ClinicalTrials.gov, 73 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 13 of these trials.

The research picture

Myelodysplastic Syndromes has 193 registered US clinical trials, 73 of them open to new participants right now, about 38% of the total.

73
recruiting participants now
38%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
13
top sponsor: Washington University School of Medicine
Phase 180Phase 268Phase 39Phase 42

Active & Recent Trials

193 total, page 3 of 4

ACTIVE NOT RECRUITING Phase 1 25 participants

A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

Dana-Farber Cancer Institute

NCT03912064

ACTIVE NOT RECRUITING Phase 1 22 participants

NTX-301 in MDS/AML

University of Alabama at Birmingham

NCT04167917

ACTIVE NOT RECRUITING Phase 1 22 participants

Inqovi Maintenance Therapy in Myeloid Neoplasms

Massachusetts General Hospital

NCT04980404

ACTIVE NOT RECRUITING Phase 1 20 participants

CPX-351 (Vyxeos™) for Transplant Eligible, Higher Risk Patients With Myelodysplastic Syndrome

Washington University School of Medicine

NCT03572764

ACTIVE NOT RECRUITING Phase 1 16 participants

Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

Jacqueline Garcia, MD

NCT05455294

ACTIVE NOT RECRUITING Phase 1 15 participants

Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

Johns Hopkins All Children's Hospital

NCT03843528

ACTIVE NOT RECRUITING Phase 1 13 participants

Canakinumab With Darbepoetin Alfa in PTs With Lower-Risk MDS Who Have Failed ESA

H. Lee Moffitt Cancer Center and Research Institute

NCT04798339

ACTIVE NOT RECRUITING Phase 2 13 participants

CPX-351 as a Novel Approach for the Treatment of Older Patients With AML and MDS

Case Comprehensive Cancer Center

NCT04668885

ACTIVE NOT RECRUITING Phase 1 10 participants

Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant

Bellicum Pharmaceuticals

NCT02477878

ACTIVE NOT RECRUITING NA 3 participants

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Baylor College of Medicine

NCT05236764

COMPLETED 1,294 participants

S9910, Collecting and Storing Blood and Bone Marrow Samples From Patients With Hematologic Cancer

SWOG Cancer Research Network

NCT00919425

COMPLETED 459 participants

Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant

City of Hope Medical Center

NCT00964821

COMPLETED Phase 2 361 participants

Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer

Roswell Park Cancer Institute

NCT00003816

COMPLETED Phase 3 254 participants

Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

Children's Oncology Group

NCT00003593

COMPLETED Phase 2 213 participants

An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)

Celgene

NCT02775903

COMPLETED Phase 3 198 participants

A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families

Tufts Medical Center

NCT00782145

COMPLETED Phase 2 182 participants

A Randomized Trial of Antithymocyte Globulin Versus Cyclosporine to Treat the Cytopenia of Myelodysplastic Syndrome

National Institutes of Health Clinical Center (CC)

NCT00001839

COMPLETED Phase 1 160 participants

Phase 1-2 Study of Low Dose ASTX727 (ASTX727 LD) in Lower Risk MDS

Taiho Oncology

NCT03502668

COMPLETED Phase 2 130 participants

S0020 Immunosuppressive Therapy in Treating Patients With Myelodysplastic Syndrome

SWOG Cancer Research Network

NCT00016419

COMPLETED Phase 2 120 participants

An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)

Millennium Pharmaceuticals

NCT02610777

COMPLETED 119 participants

Collect and Assess Tissue Samples From Subjects With Hematologic Malignancy

Notable Labs

NCT04014764

COMPLETED Phase 3 118 participants

Erythropoietin (EPO)+/- Filgrastim (G-CSF) vs. Supportive Therapy Alone for Patients With Myelodysplastic Syndromes

Eastern Cooperative Oncology Group

NCT00003138

COMPLETED Phase 2 114 participants

Genomic Predictors of Decitabine Response in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes

Washington University School of Medicine

NCT01687400

COMPLETED Phase 2 113 participants

Study of Voreloxin (Vosaroxin) in Older Patients With Untreated Acute Myeloid Leukemia

Sunesis Pharmaceuticals

NCT00607997

COMPLETED Phase 2 100 participants

Topotecan in Treating Patients With Myelodysplastic Syndrome

Alliance for Clinical Trials in Oncology

NCT00003675

COMPLETED Phase 3 98 participants

Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain

Vanderbilt-Ingram Cancer Center

NCT00666211

COMPLETED Phase 1 92 participants

Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies

Washington University School of Medicine

NCT00241358

COMPLETED 92 participants

Study of Quality of Life in Older vs. Younger Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes

Center for International Blood and Marrow Transplant Research

NCT03558386

COMPLETED Phase 2 90 participants

Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases

Roswell Park Cancer Institute

NCT00003662

COMPLETED Phase 2 82 participants

Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Cancer

Alliance for Clinical Trials in Oncology

NCT00053196

COMPLETED Phase 1 75 participants

Safety Assessment of Two Schedules of Intravenous Infusions of SNS-595 for the Treatment of Hematologic Malignancies

Sunesis Pharmaceuticals

NCT00246662

COMPLETED Phase 2 57 participants

Study of AP23573 in Patients With Relapsed or Refractory Hematologic Malignancies (8669-024)(COMPLETED)

Merck Sharp & Dohme

NCT00086125

COMPLETED Phase 1 55 participants

Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT03755414

COMPLETED Phase 1 55 participants

Safety Study of ALRN-6924 in Patients With Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome

Aileron Therapeutics

NCT02909972

COMPLETED Phase 2 53 participants

Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT00410657

COMPLETED 50 participants

Ascorbic Acid Levels in MDS, AML, and CMML Patients

Van Andel Research Institute

NCT03526666

COMPLETED Phase 1 49 participants

INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease

Children's Oncology Group

NCT01164163

COMPLETED Phase 4 49 participants

A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT

Phoenix Children's Hospital

NCT03176849

COMPLETED Phase 4 45 participants

Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

University of Maryland, Baltimore

NCT00003398

COMPLETED Phase 1 41 participants

T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer

Masonic Cancer Center, University of Minnesota

NCT00602693

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED NA 39 participants

Donor Lymphocyte Infusion in Treating Patients With Recurrent or Persistent Hematologic Cancer After Donor Stem Cell Transplant

Roswell Park Cancer Institute

NCT00534118

COMPLETED Phase 2 38 participants

A Dose Confirmation Study of Oral Clofarabine for Adult Patients Previously Treated for Myelodysplastic Syndromes (MDS)

Genzyme, a Sanofi Company

NCT00531232

COMPLETED Phase 1 38 participants

Clofarabine, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk and/or Advanced Hematologic Cancer or Other Disease

Memorial Sloan Kettering Cancer Center

NCT00423514

COMPLETED Phase 1 35 participants

Vosaroxin and Azacitidine in Treating Patients With Myelodysplastic Syndromes

Washington University School of Medicine

NCT01913951

COMPLETED Phase 2 34 participants

Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer

Case Comprehensive Cancer Center

NCT00054327

COMPLETED Phase 2 34 participants

Study to Separately Evaluate the Activity of Talacotuzumab (JNJ-56022473) or Daratumumab in Transfusion-Dependent Participants With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) Who Are Relapsed or Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment

Janssen Research & Development

NCT03011034

COMPLETED Phase 2 34 participants

Campath-1H + FK506 and Methylprednisolone for GVHD

Case Comprehensive Cancer Center

NCT00109993

COMPLETED Phase 2 32 participants

Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer

City of Hope Medical Center

NCT00589563

COMPLETED Phase 2 30 participants

Sirolimus With Tacrolimus for Graft-vs-Host Disease Prophylaxis After Un-Related Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT00144677

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 68
Phase 3 9
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelodysplastic Syndromes Trial Landscape

193 indexed Myelodysplastic Syndromes studies · 73 recruiting (38%).

Phase mix: 11 late (III/IV) vs 148 early (I/II).

Top sponsor: Washington University School of Medicine (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelodysplastic Syndromes?

PlainTrial tracks 193 US clinical trials for Myelodysplastic Syndromes, of which 73 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelodysplastic Syndromes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.