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ClinicalTrials.gov 73 recruiting now official registry

Myelodysplastic Syndromes clinical trials

73 of 193 indexed Myelodysplastic Syndromes trials are currently recruiting.

193 US clinical trials · 73 currently recruiting

Myelodysplastic Syndromes is the subject of 193 registered US clinical trials on ClinicalTrials.gov, 73 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 13 of these trials.

The research picture

Myelodysplastic Syndromes has 193 registered US clinical trials, 73 of them open to new participants right now, about 38% of the total.

73
recruiting participants now
38%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
13
top sponsor: Washington University School of Medicine
Phase 180Phase 268Phase 39Phase 42

Active & Recent Trials

193 total, page 4 of 4

COMPLETED Phase 1 28 participants

Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) in Combination With Azacitidine for the Treatment of Myelodysplastic Syndrome (MDS)

Washington University School of Medicine

NCT01065129

COMPLETED NA 26 participants

Low Dose Melphalan and Bortezomib for AML and High-Risk MDS

Dartmouth-Hitchcock Medical Center

NCT00789256

COMPLETED Phase 2 25 participants

A Phase II Study of Intravenous Azacitidine Alone in Patients With Myelodysplastic Syndromes

Washington University School of Medicine

NCT00384956

COMPLETED Phase 1 24 participants

Decitabine Maintenance for Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Post Transplant

Washington University School of Medicine

NCT00986804

COMPLETED Phase 1 23 participants

Azacytidine and Bortezomib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes

Ohio State University Comprehensive Cancer Center

NCT00624936

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED NA 18 participants

Study of Oral Dasatinib in Subjects With Myelodysplastic Syndrome (MDS) and Excess Marrow Blasts

H. Lee Moffitt Cancer Center and Research Institute

NCT00624585

COMPLETED Phase 1 16 participants

Cytarabine and UCN-01 in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia or Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00004263

COMPLETED Phase 1 15 participants

Combination of Sorafenib and Vorinostat in Poor-risk Acute Myelogenous Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)

Indiana University School of Medicine

NCT00875745

COMPLETED Phase 2 14 participants

Multi-Ctr PII Cmb.Modality Tx Ruxolitinib, Decitabine, and DLI for Post HSCT in AML/MDS

Masonic Cancer Center, University of Minnesota

NCT04055844

COMPLETED Phase 1 14 participants

CPX-351 Salvage Therapy Followed by Haplo-Cord Transplant for Relapsed/Refractory Leukemia or Myelodysplastic Syndrome

Weill Medical College of Cornell University

NCT03393611

COMPLETED Phase 2 14 participants

Experimental Bone Marrow Transplant Protocol

National Heart, Lung, and Blood Institute (NHLBI)

NCT00061581

COMPLETED Phase 1 14 participants

Decitabine and Peripheral Stem Cell Transplantation in Treating Patients Who Have Relapsed Following Bone Marrow Transplantation for Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

M.D. Anderson Cancer Center

NCT00002832

COMPLETED Phase 2 12 participants

Amifostine in Treating Patients With Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00003048

COMPLETED Phase 2 12 participants

A Study of E7820 in People With Bone Marrow (Myeloid) Cancers

Memorial Sloan Kettering Cancer Center

NCT05024994

COMPLETED Phase 2 12 participants

Chemotherapy and a Donor Natural Killer Cell Infusion in Treating Patients With Relapsed or Persistent Leukemia or Myelodysplastic Syndrome After a Donor Stem Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT00526292

COMPLETED Phase 2 8 participants

Bortezomib in Treating Patients With Myelodysplastic Syndromes

University of Rochester

NCT00262873

COMPLETED Phase 1 7 participants

Low-Dose Fludarabine, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer

University of California, San Francisco

NCT00301951

COMPLETED Phase 2 7 participants

CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML

Robert Lowsky

NCT04151706

COMPLETED Phase 1 7 participants

Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

M.D. Anderson Cancer Center

NCT00005092

COMPLETED Phase 1 5 participants

Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer

University of California, San Francisco

NCT00304018

COMPLETED Phase 1 5 participants

Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy

Dana-Farber Cancer Institute

NCT00005988

COMPLETED Phase 1 4 participants

A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations

NYU Langone Health

NCT03433781

COMPLETED Phase 2 3 participants

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Roswell Park Cancer Institute

NCT00003661

COMPLETED Phase 1 1 participants

Vaccine Therapy in Treating Patients With Myelodysplastic Syndrome

Memorial Sloan Kettering Cancer Center

NCT00003959

COMPLETED Phase 2

Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Advanced Hematologic Cancer

Memorial Sloan Kettering Cancer Center

NCT00014469

COMPLETED Phase 1

Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia

Drexel University College of Medicine

NCT00003619

COMPLETED Phase 2

Busulfan and Cyclophosphamide Followed by Bone Marrow Transplantation in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Northwestern University

NCT00004896

COMPLETED Phase 2

Combination Chemotherapy and Bone Marrow Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome

Memorial Sloan Kettering Cancer Center

NCT00002502

COMPLETED Phase 1

Perifosine in Treating Patients With Refractory Solid Tumors or Hematologic Cancer

National Cancer Institute (NCI)

NCT00019656

COMPLETED Phase 1

Bone Marrow and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Northwestern University

NCT00004232

COMPLETED Phase 1

Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation

National Institutes of Health Clinical Center (CC)

NCT00064311

COMPLETED Phase 2

Thalidomide and Epoetin Alfa in Treating Anemia in Patients With Myelodysplastic Syndrome

Fallon Clinic

NCT00053001

COMPLETED Phase 2

Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

Fred Hutchinson Cancer Center

NCT00005804

COMPLETED Phase 1

Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors

Indiana University School of Medicine

NCT00003107

COMPLETED Phase 2

Azacitidine Plus Amifostine in Treating Patients With Myelodysplastic Syndrome

University of Michigan Rogel Cancer Center

NCT00005598

COMPLETED Phase 1

PS-341 in Treating Patients With Hematologic Cancer

Memorial Sloan Kettering Cancer Center

NCT00006098

COMPLETED Phase 1

Radiolabeled Monoclonal Antibody Therapy and Etoposide Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Myelodysplastic Syndrome or Refractory Leukemia

Memorial Sloan Kettering Cancer Center

NCT00006040

COMPLETED NA

Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation

Memorial Sloan Kettering Cancer Center

NCT00014482

COMPLETED Phase 2

Doxercalciferol in Treating Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

University of Wisconsin, Madison

NCT00052832

COMPLETED Phase 3

Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter

Jonsson Comprehensive Cancer Center

NCT00006083

COMPLETED Phase 2

Bevacizumab, Cytarabine, and Mitoxantrone on Treating Patients With Hematologic Cancers

University of Maryland, Baltimore

NCT00015951

COMPLETED Phase 1

Cyclophosphamide Plus Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00006042

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 68
Phase 3 9
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelodysplastic Syndromes Trial Landscape

193 indexed Myelodysplastic Syndromes studies · 73 recruiting (38%).

Phase mix: 11 late (III/IV) vs 148 early (I/II).

Top sponsor: Washington University School of Medicine (13 trials), 9 others listed. 43 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelodysplastic Syndromes?

PlainTrial tracks 193 US clinical trials for Myelodysplastic Syndromes, of which 73 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelodysplastic Syndromes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.