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NCT02477878 · ClinicalTrials.gov registry record · Phase 1
Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant
A Phase 1 study of Multiple Myeloma and Lymphoma, sponsored by Bellicum Pharmaceuticals.
- Active
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
- 5
- Study locations
NCT02477878: Active Phase 1 study of Multiple Myeloma and Lymphoma, sponsored by Bellicum Pharmaceuticals.
NCT02477878 is a Phase 1 study of Multiple Myeloma and Lymphoma that is active but no longer recruiting, run by Bellicum Pharmaceuticals. The registered enrollment target is 10 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (98% lower). The trial reports 5 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02477878, a Phase 1 study of Multiple Myeloma and Lymphoma, is active but no longer recruiting, sponsored by Bellicum Pharmaceuticals.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
- 5
- Study locations
Study Summary
A Phase I study of BPX-501 T cell infusion in adults with recurrent or minimal residual disease (MRD) hematologic malignancies post-allogeneic transplant. The treatment consists of increasing doses of BPX-501 T cell infusions to achieve a clinical response. Rimiducid will be investigated for the treatment of aGvHD after BPX-501 T cell infusion to determine a dose that can mitigate GvHD and preserve the graft versus leukemia effect.
Primary Outcome
To evaluate the safety of 2 stratified dose levels of BPX-501 T cell infusions based on patient-donor match in adult subjects with hematological malignancies
Conditions Studied
Interventions
- DRUG Rimiducid
- BIOLOGICAL BPX-501
Study Locations (5)
Georgia
- BMT Program at Northside Hospital - Atlanta
Kansas
- University of Kansas - Westwood
New York
- Roswell Park - Buffalo
Oregon
- Oregon Health & Science University - Portland
Texas
- UT Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2016-07 |
| Est. Completion | 2033-01 |
| Phase | Phase 1 |
What the registry record for NCT02477878 still lists
NCT02477878 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (98% lower).
The record links to 5 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions - of which Rimiducid is the first listed.
NCT02477878 lists 5 locations in 5 states (Georgia, Kansas, New York).
Frequently Asked Questions
What is clinical trial NCT02477878 about?
NCT02477878 is a clinical study titled "Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant". A Phase I study of BPX-501 T cell infusion in adults with recurrent or minimal residual disease (MRD) hematologic malignancies post-allogeneic transplant. The treatment consists of increasing doses of BPX-501 T cell infusions to achieve a clinical response. Rimiducid will be investigated for the tre...
What is the current status of trial NCT02477878?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2016-07. Estimated completion is 2033-01.
What conditions does trial NCT02477878 study?
This clinical trial studies the following conditions: Multiple Myeloma, Lymphoma, Leukemia, Myelodysplastic Syndromes, Hematologic Neoplasms.
What interventions are being tested in trial NCT02477878?
The interventions under investigation include: Rimiducid (DRUG), BPX-501 (BIOLOGICAL).
Who is sponsoring clinical trial NCT02477878?
This trial is sponsored by Bellicum Pharmaceuticals, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02477878 being conducted?
This trial has 5 study locations across Georgia, Kansas, New York, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
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Where NCT02477878's enrollment target sits among peer trials
10 419th of 438 higher than 14 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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