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ClinicalTrials.gov 73 recruiting now official registry

Myelodysplastic Syndromes clinical trials

73 of 193 indexed Myelodysplastic Syndromes trials are currently recruiting.

193 US clinical trials · 73 currently recruiting

Myelodysplastic Syndromes is the subject of 193 registered US clinical trials on ClinicalTrials.gov, 73 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 13 of these trials.

The research picture

Myelodysplastic Syndromes has 193 registered US clinical trials, 73 of them open to new participants right now, about 38% of the total.

73
recruiting participants now
38%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
13
top sponsor: Washington University School of Medicine
Phase 180Phase 268Phase 39Phase 42

Active & Recent Trials

193 total, page 2 of 4

RECRUITING Phase 2 37 participants

A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies

Franziska Wachter

NCT05796570

RECRUITING Phase 1 36 participants

Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

Tr1X

NCT06462365

RECRUITING Phase 2 36 participants

Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood

Case Comprehensive Cancer Center

NCT06904482

RECRUITING Phase 1 30 participants

IS-free Treg HaploHCT

Dana-Farber Cancer Institute

NCT04678401

RECRUITING 30 participants

Umbilical Cord Blood Transplantation From Unrelated Donors

University of Rochester

NCT03016806

RECRUITING NA 30 participants

Home Blood Transfusions

Thomas Jefferson University

NCT07121140

RECRUITING Phase 2 29 participants

Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant

University of Alabama at Birmingham

NCT06315309

RECRUITING Phase 1 27 participants

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

Taiho Oncology

NCT04953910

RECRUITING Phase 1 26 participants

Leflunomide in Combination With Decitabine for Treatment of Relapsed or Refractory Myelodysplastic Syndromes

West Virginia University

NCT06923488

RECRUITING Phase 2 25 participants

Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations

Abhay Singh, MD MPH

NCT06630221

RECRUITING Early Phase 1 24 participants

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

Omar Aljitawi

NCT03964506

RECRUITING Phase 1 24 participants

Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

Stanford University

NCT06551584

RECRUITING Phase 1 23 participants

Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS

University of Virginia

NCT07270978

RECRUITING Phase 1 20 participants

Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies

University of Alabama at Birmingham

NCT07044544

RECRUITING Phase 2 20 participants

ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis

Leland Metheny

NCT06680661

RECRUITING Early Phase 1 20 participants

5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Benjamin Tomlinson

NCT04187703

RECRUITING Phase 2 20 participants

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

University of Florida

NCT05800210

RECRUITING Phase 1 18 participants

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

Taiho Oncology

NCT04953897

RECRUITING Phase 2 16 participants

Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)

Washington University School of Medicine

NCT05483010

RECRUITING Phase 2 15 participants

A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.

M.D. Anderson Cancer Center

NCT06566742

RECRUITING Phase 1 15 participants

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT06138587

RECRUITING Phase 1 12 participants

Iadademstat With Hypomethylating Agent in Patients With Myelodysplastic Syndrome

Medical College of Wisconsin

NCT06502145

RECRUITING

3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer

Barbara Ann Karmanos Cancer Institute

NCT00935090

ACTIVE NOT RECRUITING Phase 3 363 participants

A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve

Celgene

NCT03682536

ACTIVE NOT RECRUITING NA 320 participants

A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy

Massachusetts General Hospital

NCT03310918

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING Phase 2 300 participants

HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Center for International Blood and Marrow Transplant Research

NCT04904588

ACTIVE NOT RECRUITING Phase 2 289 participants

Study to Evaluate Imetelstat (GRN163L) in Participants With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

Geron Corporation

NCT02598661

ACTIVE NOT RECRUITING Phase 1 255 participants

Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Orca Biosystems

NCT04013685

ACTIVE NOT RECRUITING Phase 2 230 participants

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)

Bristol-Myers Squibb

NCT05469737

ACTIVE NOT RECRUITING Phase 2 206 participants

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

St. Jude Children's Research Hospital

NCT03164057

ACTIVE NOT RECRUITING Phase 1 181 participants

A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies

Faron Pharmaceuticals

NCT05428969

ACTIVE NOT RECRUITING Phase 1 120 participants

Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant

Bellicum Pharmaceuticals

NCT03301168

ACTIVE NOT RECRUITING NA 109 participants

Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies

Rigshospitalet, Denmark

NCT03682029

ACTIVE NOT RECRUITING Phase 3 106 participants

A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants

Bristol-Myers Squibb

NCT06045689

ACTIVE NOT RECRUITING Phase 2 105 participants

Palliative Care Oncology in Patients With Relapsed, Refractory, and High-Risk Leukemias or MDS

University of Virginia

NCT04482894

ACTIVE NOT RECRUITING 100 participants

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Massachusetts General Hospital

NCT04902833

ACTIVE NOT RECRUITING Phase 1 88 participants

PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS

Precigen

NCT03927261

ACTIVE NOT RECRUITING Phase 2 87 participants

A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)

Agios Pharmaceuticals

NCT05490446

ACTIVE NOT RECRUITING 80 participants

AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration

Washington University School of Medicine

NCT04263181

ACTIVE NOT RECRUITING Phase 1 75 participants

Helical Tomotherapy, Fludarabine Phosphate, and Melphalan Followed By Allo-HSCT in Hematological Malignancies

City of Hope Medical Center

NCT00544466

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML

Treadwell Therapeutics

NCT04730258

ACTIVE NOT RECRUITING NA 60 participants

Electronic Health Mindfulness-based Music Therapy Intervention for Patients Undergoing Allogeneic Stem Cell Transplantation

University of Miami

NCT05968963

ACTIVE NOT RECRUITING Phase 1 50 participants

A Pilot Trial of Atorvastatin in Tumor Protein 53 (p53) -Mutant and p53 Wild-Type Malignancies

Joaquina Baranda

NCT03560882

ACTIVE NOT RECRUITING Phase 1 43 participants

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

University of Michigan Rogel Cancer Center

NCT03842696

ACTIVE NOT RECRUITING Phase 1 40 participants

A Phase 1, Open-Label, Sequential Cross-over, Bioavailability/Bioequivalence Study to Compare the Pharmacokinetics of Oral Cladribine With the Reference Listed Drug, Intravenous Cladribine

M.D. Anderson Cancer Center

NCT06021600

ACTIVE NOT RECRUITING Phase 2 38 participants

Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

University of Illinois at Chicago

NCT03121014

ACTIVE NOT RECRUITING Phase 1 36 participants

Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

Bellicum Pharmaceuticals

NCT01744223

ACTIVE NOT RECRUITING Phase 2 33 participants

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.

Novartis Pharmaceuticals

NCT05201066

ACTIVE NOT RECRUITING Phase 1 32 participants

Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05823571

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 68
Phase 3 9
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelodysplastic Syndromes Trial Landscape

193 indexed Myelodysplastic Syndromes studies · 73 recruiting (38%).

Phase mix: 11 late (III/IV) vs 148 early (I/II).

Top sponsor: Washington University School of Medicine (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelodysplastic Syndromes?

PlainTrial tracks 193 US clinical trials for Myelodysplastic Syndromes, of which 73 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelodysplastic Syndromes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.