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NCT01164163 · ClinicalTrials.gov registry record · Phase 1
INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease
A Phase 1 study of Leukemia and Myelodysplastic Syndromes, sponsored by Children's Oncology Group.
- Completed
- Registry status
- Phase 1
- Development phase
- 49
- Enrollment target
- 20
- Study locations
NCT01164163 is a Phase 1 study of Leukemia and Myelodysplastic Syndromes that has completed, run by Children's Oncology Group. The registered enrollment target is 49 participants, below the 487-participant average among 233 other Leukemia trials with a reported enrollment target (90% lower). The trial reports 20 study locations across 17 states.
The verdict
NCT01164163, a Phase 1 study of Leukemia and Myelodysplastic Syndromes, has completed, sponsored by Children's Oncology Group.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 49 participants
- Enrollment target
- 20
- Study locations
Study Summary
RATIONALE: INCB18424 (Ruxolitinib) may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase 1 clinical trial is studying the side effects and best dose of INCB18424 in treating young patients with relapsed or refractory solid tumor, leukemia, or myeloproliferative disease.
Conditions Studied
Interventions
- OTHER laboratory biomarker analysis
- OTHER pharmacological study
- DRUG ruxolitinib phosphate
Study Locations (20)
California
- Children's Hospital of Orange County - Orange
- UCSF Helen Diller Family Comprehensive Cancer Center - San Francisco
Maryland
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins - Baltimore
- Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office - Bethesda
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
- Children's Hospital of Pittsburgh of UPMC - Pittsburgh
Alabama
- UAB Comprehensive Cancer Center - Birmingham
Colorado
- Children's Hospital Colorado Center for Cancer and Blood Disorders - Aurora
District of Columbia
- Children's National Medical Center - Washington D.C.
Georgia
- AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus - Atlanta
Illinois
- Children's Memorial Hospital - Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 49 participants |
| Start Date | 2010-09 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01164163
The ClinicalTrials.gov registry entry for NCT01164163 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 49 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 487-participant average among 233 other Leukemia trials with a reported enrollment target (90% lower). The listed sponsor is Children's Oncology Group, which has 342 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Leukemia appearing as the primary indexed condition, and to 3 interventions - of which laboratory biomarker analysis is the first listed.
NCT01164163 reports 20 study locations spanning 17 distinct geographic areas - top geographies include California, Maryland, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01164163 about?
NCT01164163 is a clinical study titled "INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease". RATIONALE: INCB18424 (Ruxolitinib) may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase 1 clinical trial is studying the side effects and best dose of INCB18424 in treating young patients with relapsed or refractory solid tumor, leukemia, o...
What is the current status of trial NCT01164163?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 49 participants. The study started on 2010-09.
What conditions does trial NCT01164163 study?
This clinical trial studies the following conditions: Leukemia, Myelodysplastic Syndromes, Chronic Myeloproliferative Disorders, Myelodysplastic/Myeloproliferative Neoplasms, Unspecified Childhood Solid Tumor, Protocol Specific.
What interventions are being tested in trial NCT01164163?
The interventions under investigation include: laboratory biomarker analysis (OTHER), pharmacological study (OTHER), ruxolitinib phosphate (DRUG).
Who is sponsoring clinical trial NCT01164163?
This trial is sponsored by Children's Oncology Group, which has 342 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01164163 being conducted?
This trial has 20 study locations across Alabama, California, Colorado, District of Columbia, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.