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Multiple System Atrophy clinical trials
18 of 31 indexed Multiple System Atrophy trials are currently recruiting.
31 US clinical trials · 18 currently recruiting
Multiple System Atrophy is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 7 of these trials.
The research picture
Multiple System Atrophy has 31 registered US clinical trials, 18 of them open to new participants right now, about 58% of the total.
- 18
- recruiting participants now
- 58%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Vanderbilt University Medical Center
Active & Recent Trials
31 total, page 1 of 1
Natural History Study of Synucleinopathies
NYU Langone Health
NCT01799915
North American Prodromal Synucleinopathy Consortium Stage 2
Washington University School of Medicine
NCT05826457
A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D
NCT06568237
An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D
NCT07197866
Gait Analysis in Neurological Disease
Beth Israel Deaconess Medical Center
NCT02994719
Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging
University of Texas Southwestern Medical Center
NCT03872102
A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy
Yoda Therapeutics
NCT06848231
CPAP for the Treatment of Supine Hypertension
Vanderbilt University Medical Center
NCT05489575
PET Imaging Evaluation of [11C]SY08
Massachusetts General Hospital
NCT06098612
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Daniel Claassen
NCT04246437
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Vanderbilt University Medical Center
NCT02897063
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
Vanderbilt University Medical Center
NCT04620382
Automated Abdominal Binder for Orthostatic Hypotension
Vanderbilt University Medical Center
NCT03482297
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms
Vanderbilt University Medical Center
NCT04782830
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Vanderbilt University Medical Center
NCT02429557
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Vanderbilt University Medical Center
NCT03042988
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
Craig van Horne, MD, PhD
NCT06683365
A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)
Tiziana Life Sciences
NCT06868628
Trial of Parkinson's And Zoledronic Acid
California Pacific Medical Center Research Institute
NCT03924414
Community Outreach for Palliative Engagement -- Parkinson Disease
University of Rochester
NCT05222386
A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA)
H. Lundbeck A/S
NCT06706622
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
AskBio
NCT05699460
Clinical Laboratory Evaluation of Chronic Autonomic Failure
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03648905
Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy
Mayo Clinic
NCT05167721
A Study of Lu AF82422 in Participants With Multiple System Atrophy
H. Lundbeck A/S
NCT05104476
GDNF Gene Therapy for Multiple System Atrophy
Brain Neurotherapy Bio
NCT04680065
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
Vanderbilt University
NCT02726711
Diagnosis and Natural History Study of Patients With Neurological Conditions
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001549
Speech Accessibility Project
University of Illinois at Urbana-Champaign
NCT05889260
Synuclein-One Study
CND Life Sciences
NCT04700722
In-Home Care for Patients With PSP and Related Disorders
Rush University Medical Center
NCT03552484
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple System Atrophy Trial Landscape
31 indexed Multiple System Atrophy studies · 18 recruiting (58%).
Phase mix: 2 late (III/IV) vs 15 early (I/II).
Top sponsor: Vanderbilt University Medical Center (7 trials), 9 others listed. 31 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple System Atrophy?
PlainTrial tracks 31 US clinical trials for Multiple System Atrophy, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple System Atrophy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.