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Multiple System Atrophy: early-phase trial registry
18 of 31 indexed Multiple System Atrophy trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #495 of 28,707 conditions by registered trial count.
31 US clinical trials · 18 currently recruiting · #495 of 28,707 conditions by registered trial count
Multiple System Atrophy: 31 US clinical trials tracked, 18 recruiting.
Multiple System Atrophy is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 7 of these trials.
Enrollment posture brief
Registry condition multiple-system-atrophy
OPEN 18 | RECR 58% | LATE 2 | EARLY 15 | RANK #495 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Cognitive Decline (58% recruiting · 62 trials)
Multiple System Atrophy lists 18 open slots (58% of 31 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Multiple System Atrophy on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Multiple System Atrophy is recruiting above its size-band peers.
18 of 31 indexed trials (58.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Multiple System Atrophy research.
Vanderbilt University Medical Center accounts for 7 of 31 trials (22.6%). 22 distinct sponsors appear on at least one study for this condition label.
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Most Multiple System Atrophy trials plan to enrol fewer than 100 people.
Median target enrolment is 71 among the 31 trials that report a genuine target (sentinel values excluded). 19 of those (61.3%) plan for fewer than 100 participants.
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Multiple System Atrophy research is mostly interventional.
22 interventional and 9 observational studies make up this index (71% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
31 total, page 1 of 1
Natural History Study of Synucleinopathies
NYU Langone Health
NCT01799915
North American Prodromal Synucleinopathy Consortium Stage 2
Washington University School of Medicine
NCT05826457
A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D
NCT06568237
An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy
Teva Branded Pharmaceutical Products R&D
NCT07197866
Gait Analysis in Neurological Disease
Beth Israel Deaconess Medical Center
NCT02994719
Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging
University of Texas Southwestern Medical Center
NCT03872102
A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy
Yoda Therapeutics
NCT06848231
CPAP for the Treatment of Supine Hypertension
Vanderbilt University Medical Center
NCT05489575
PET Imaging Evaluation of [11C]SY08
Massachusetts General Hospital
NCT06098612
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Daniel Claassen
NCT04246437
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Vanderbilt University Medical Center
NCT02897063
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
Vanderbilt University Medical Center
NCT04620382
Automated Abdominal Binder for Orthostatic Hypotension
Vanderbilt University Medical Center
NCT03482297
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms
Vanderbilt University Medical Center
NCT04782830
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Vanderbilt University Medical Center
NCT02429557
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Vanderbilt University Medical Center
NCT03042988
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
Craig van Horne, MD, PhD
NCT06683365
A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)
Tiziana Life Sciences
NCT06868628
Trial of Parkinson's And Zoledronic Acid
California Pacific Medical Center Research Institute
NCT03924414
Community Outreach for Palliative Engagement -- Parkinson Disease
University of Rochester
NCT05222386
A Trial of Amlenetug (Lu AF82422) in Participants With Multiple System Atrophy (MSA)
H. Lundbeck A/S
NCT06706622
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
AskBio
NCT05699460
Clinical Laboratory Evaluation of Chronic Autonomic Failure
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03648905
Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy
Mayo Clinic
NCT05167721
A Study of Lu AF82422 in Participants With Multiple System Atrophy
H. Lundbeck A/S
NCT05104476
GDNF Gene Therapy for Multiple System Atrophy
Brain Neurotherapy Bio
NCT04680065
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
Vanderbilt University
NCT02726711
Diagnosis and Natural History Study of Patients With Neurological Conditions
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001549
Speech Accessibility Project
University of Illinois at Urbana-Champaign
NCT05889260
Synuclein-One Study
CND Life Sciences
NCT04700722
In-Home Care for Patients With PSP and Related Disorders
Rush University Medical Center
NCT03552484
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Multiple System Atrophy records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Multiple System Atrophy trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Multiple System Atrophy page
31 registered trials, 18 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 18 Multiple System Atrophy trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Vanderbilt University Medical Center sponsors the most Multiple System Atrophy trials on record, review their full trial history before evaluating a specific study. See Vanderbilt University Medical Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Multiple System Atrophy condition card totals 31 registered trials; most-linked intervention Placebo; top US site state Tennessee. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.