Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Alcohol Use Disorder (AUD)

Open-data reference.

31 US clinical trials · 22 currently recruiting

Active & Recent Trials

RECRUITING NA 330 participants

Combining a Smartphone App With Medications to Manage Heavy Drinking

VA Office of Research and Development

NCT06303778

RECRUITING Phase 2 205 participants

Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

Washington State University

NCT05181891

RECRUITING Phase 2 205 participants

The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study

Washington State University

NCT05134857

RECRUITING NA 200 participants

The Oklahoma Parent-Child Assistance Program

University of Oklahoma

NCT05534568

RECRUITING 200 participants

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Yale University

NCT06624137

RECRUITING NA 200 participants

Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

University of Illinois at Urbana-Champaign

NCT07125534

RECRUITING Phase 2 184 participants

Alpha-1 Blockade for Alcohol Use Disorder (AUD)

Brown University

NCT04135846

RECRUITING Phase 1 180 participants

Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT06484075

RECRUITING Phase 2 120 participants

Probenecid Administration for Alcohol Craving and Consumption

Brown University

NCT07118618

RECRUITING NA 86 participants

MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

Medical University of South Carolina

NCT04998916

RECRUITING NA 80 participants

Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building

University of Rhode Island

NCT07217795

RECRUITING Phase 2 76 participants

Suvorexant for Treatment of AUD and PTSD

Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

NCT06679062

RECRUITING Phase 1 63 participants

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

Yale University

NCT06070649

RECRUITING Phase 1 63 participants

Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers

Yale University

NCT06136195

RECRUITING NA 42 participants

iTBS for Alcohol Use Disorder

Nicholas Balderston, PhD

NCT06696365

RECRUITING Phase 2 40 participants

Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)

Nathan Brashares Sackett

NCT06853912

RECRUITING Phase 2 30 participants

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

Yale University

NCT07040592

RECRUITING 30 participants

Developing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery

Washington State University

NCT07052318

RECRUITING NA 30 participants

Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Alcohol Use Disorder

University of Georgia

NCT06987526

RECRUITING Phase 1 24 participants

Diclofenac Dose Response Study

University of Maryland, Baltimore

NCT06636227

RECRUITING Phase 2 20 participants

Study of Tirzepatide for Recovery and Alcohol Use Management

Brigham and Women's Hospital

NCT06727331

RECRUITING Phase 1 10 participants

Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

NCT06335407

ACTIVE NOT RECRUITING 192 participants

Comprehensive Process Model of AA-related Behavior Change

University of New Mexi

NCT04618653

ACTIVE NOT RECRUITING Phase 2 110 participants

A Study to Investigate the Safety and Efficacy of TMP-301 Compared to Placebo in Adult Patients With Alcohol Use Disorder

Tempero Bio

NCT06648655

ACTIVE NOT RECRUITING Phase 2 100 participants

RECLAIM STUDY: A Phase 2 Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol Use Disorder (AUD) in Subjects With Obesity or Overweight

Altimmune

NCT06987513

ACTIVE NOT RECRUITING Phase 2 50 participants

Ibudilast for Treating Alcohol Use Disorder

University of Pennsylvania

NCT05414240

COMPLETED NA 41,843 participants

Alcohol Telemedicine Consultation in Primary Care (ATC)

Kaiser Permanente

NCT05252221

COMPLETED NA 9,590 participants

Michigan SPARC Trial

Kaiser Permanente

NCT04861792

COMPLETED Phase 2 320 participants

A Randomized, Double-blind Placebo-Controlled Pharmacogenetic Study of Topiramate in European-American Heavy Drinkers

University of Pennsylvania

NCT02371889

COMPLETED Early Phase 1 74 participants

Brain Inflammation and Function in Alcoholism

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT02233868

COMPLETED NA 21 participants

Brain Network Modulation and Alcohol Use

Virginia Polytechnic Institute and State University

NCT04828577

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alcohol Use Disorder (AUD) Trial Landscape

ClinicalTrials.gov lists 31 US studies indexed under Alcohol Use Disorder (AUD), and 22 of those are currently open to recruitment — roughly 71% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Alcohol Use Disorder (AUD) shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Alcohol Use Disorder (AUD) is led by Yale University with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alcohol Use Disorder (AUD)?

PlainTrial tracks 31 US clinical trials for Alcohol Use Disorder (AUD), of which 22 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alcohol Use Disorder (AUD)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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