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NCT03482297 · ClinicalTrials.gov registry record · Phase 1
Automated Abdominal Binder for Orthostatic Hypotension
A Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 31
- Enrollment target
- 1
- Study location
NCT03482297: Recruiting Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, sponsored by Vanderbilt University Medical Center.
NCT03482297 is a Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 31 participants, below the 267-participant average among 30 other Multiple System Atrophy trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03482297, a Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 31 participants
- Enrollment target
- 1
- Study location
Study Summary
The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The purpose of this study is to determine safety and effectiveness of the automated abdominal binder in improving orthostatic tolerance in these patients.
Primary Outcome
orthostatic tolerance is defined as the area under the curve of the upright systolic blood pressure (AUCSBP) during the Morning Orthostatic Trials
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Midodrine
- DEVICE automated abdominal binder
- DEVICE Sham binder
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center/ Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2018-03-01 |
| Est. Completion | 2026-12-01 |
| Phase | Phase 1 |
What NCT03482297 shows while recruiting
NCT03482297 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 267-participant average among 30 other Multiple System Atrophy trials with a reported enrollment target (88% lower).
The record links to 4 conditions, with Multiple System Atrophy appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT03482297 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT03482297 about?
NCT03482297 is a clinical study titled "Automated Abdominal Binder for Orthostatic Hypotension". The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The purpose of this study is to determine safety and effectiveness of the automated abdominal binder in improving o...
What is the current status of trial NCT03482297?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 31 participants. The study started on 2018-03-01. Estimated completion is 2026-12-01.
What conditions does trial NCT03482297 study?
This clinical trial studies the following conditions: Multiple System Atrophy, Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure.
What interventions are being tested in trial NCT03482297?
The interventions under investigation include: Placebo (DRUG), Midodrine (DRUG), automated abdominal binder (DEVICE), Sham binder (DEVICE).
Who is sponsoring clinical trial NCT03482297?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03482297 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple System Atrophy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03482297's enrollment target sits among peer trials
31 23rd of 30 higher than 7 of 30 other Multiple System Atrophy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple System Atrophy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
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Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
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GDNF Gene Therapy for Multiple System Atrophy
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Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
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