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2026 data Public-data reference. official source

Anaplastic Astrocytoma

Open-data reference.

31 US clinical trials · 13 currently recruiting

Active & Recent Trials

RECRUITING 350 participants

Targeted Pediatric High-Grade Glioma Therapy

Nationwide Children's Hospital

NCT05839379

RECRUITING Phase 2 120 participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Nationwide Children's Hospital

NCT05843253

RECRUITING Phase 1 102 participants

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Jazz Pharmaceuticals

NCT04541082

RECRUITING Phase 1 62 participants

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

The Methodist Hospital Research Institute

NCT03603405

RECRUITING Phase 1 54 participants

Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA

Northwell Health

NCT01269853

RECRUITING Phase 2 37 participants

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Northwell Health

NCT02800486

RECRUITING Phase 2 33 participants

DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma

Ashish Shah

NCT06264388

RECRUITING 30 participants

Loupe-Based Intraoperative Fluorescence Imaging

Guoqiang Yu

NCT04780009

RECRUITING Phase 1 28 participants

Study of Pembrolizumab and M032 (NSC 733972)

University of Alabama at Birmingham

NCT05084430

RECRUITING Phase 1 24 participants

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

University of Nebraska

NCT05698524

RECRUITING Phase 1 20 participants

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

University of Miami

NCT05956821

RECRUITING NA 20 participants

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Columbia University

NCT06108206

RECRUITING Early Phase 1 15 participants

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

NCT06333899

ACTIVE NOT RECRUITING Phase 4 163 participants

Pediatric Long-Term Follow-up and Rollover Study

Novartis Pharmaceuticals

NCT03975829

ACTIVE NOT RECRUITING Phase 2 120 participants

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

NRG Oncology

NCT03180502

ACTIVE NOT RECRUITING Phase 2 58 participants

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

National Cancer Institute (NCI)

NCT03919071

ACTIVE NOT RECRUITING Phase 2 38 participants

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

National Cancer Institute (NCI)

NCT03581292

ACTIVE NOT RECRUITING Phase 1 35 participants

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Children's Oncology Group

NCT04978727

COMPLETED Phase 2 112 participants

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

National Cancer Institute (NCI)

NCT00995007

COMPLETED Phase 1 62 participants

Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

Katy Peters

NCT00610571

COMPLETED Phase 1 37 participants

PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas

Duke University

NCT00612651

COMPLETED Phase 1 36 participants

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Julie Krystal

NCT01837862

COMPLETED Phase 2 30 participants

A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma

H. Lee Moffitt Cancer Center and Research Institute

NCT00606008

COMPLETED Phase 1 29 participants

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

National Cancer Institute (NCI)

NCT02101905

COMPLETED Phase 1 22 participants

AZD8055 for Adults With Recurrent Gliomas

National Cancer Institute (NCI)

NCT01316809

COMPLETED Phase 1 19 participants

A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

Children's Hospital Medical Center, Cincinnati

NCT03355794

COMPLETED Phase 1 15 participants

Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA

Northwell Health

NCT01238237

COMPLETED Phase 1 12 participants

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Biogen

NCT00031083

COMPLETED Phase 1 11 participants

Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma

Northwell Health

NCT00301418

COMPLETED Phase 1 10 participants

Cellular Immunotherapy Study for Brain Cancer

Jonsson Comprehensive Cancer Center

NCT01144247

COMPLETED Phase 1 6 participants

Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2

City of Hope Medical Center

NCT01082926

Phase Distribution

PhaseTrial count
Early Phase 1 19
Phase 2 8
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anaplastic Astrocytoma Trial Landscape

ClinicalTrials.gov lists 31 US studies indexed under Anaplastic Astrocytoma, and 13 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Anaplastic Astrocytoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Anaplastic Astrocytoma is led by National Cancer Institute (NCI) with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anaplastic Astrocytoma?

PlainTrial tracks 31 US clinical trials for Anaplastic Astrocytoma, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anaplastic Astrocytoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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