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Aortic Valve Stenosis: early-phase trial registry
13 of 31 indexed Aortic Valve Stenosis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #495 of 28,707 conditions by registered trial count.
31 US clinical trials · 13 currently recruiting · #495 of 28,707 conditions by registered trial count
Aortic Valve Stenosis: 31 US clinical trials tracked, 13 recruiting.
Aortic Valve Stenosis is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Edwards Lifesciences, running 3 of these trials.
Enrollment posture brief
Registry condition aortic-valve-stenosis
OPEN 13 | RECR 42% | LATE 0 | EARLY 1 | RANK #495 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Polycystic Ovary Syndrome (42% recruiting · 31 trials)
Aortic Valve Stenosis lists 13 open slots (42% of 31 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Aortic Valve Stenosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Aortic Valve Stenosis is recruiting above its size-band peers.
13 of 31 indexed trials (41.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Aortic Valve Stenosis trials is spread across many organizations.
Edwards Lifesciences accounts for 3 of 31 trials (9.7%). 26 distinct sponsors appear on at least one study for this condition label.
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Typical Aortic Valve Stenosis enrolment sits around 200 participants.
Median target enrolment is 200 among the 31 trials that report a genuine target (sentinel values excluded). 12 of those (38.7%) plan for fewer than 100 participants.
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Aortic Valve Stenosis splits between interventional and observational designs.
21 interventional and 10 observational studies make up this index (67.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
31 total, page 1 of 1
STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)
The Society of Thoracic Surgeons
NCT01737528
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
Edwards Lifesciences
NCT04889872
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Semmelweis University
NCT07016477
Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
NCT05459233
Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial
Cedars-Sinai Medical Center
NCT06817148
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Edwards Lifesciences
NCT05172973
Effect of Fetal Aortic Valvuloplasty on Outcomes
Queen Silvia Children's Hospital, Gothenburg, Sweden
NCT05386173
CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation
University of Colorado, Denver
NCT07008911
Imaging Histone Deacetylase in the Heart
Massachusetts General Hospital
NCT03549559
MRI in Transcatheter Aortic Valve Replacement Patients
University Hospitals Cleveland Medical Center
NCT05603026
Platelet Adhesion in the Pathobiology of Aortic Stenosis
University of Virginia
NCT05550896
Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR
Baylor Research Institute
NCT05862558
Detecting Changes in Arterial Blood Volume and Cardiac Efficiency
HemoCept
NCT07205341
Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients
Medtronic Cardiovascular
NCT02701283
Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial
Abbott Medical Devices
NCT02000115
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
Medtronic Cardiovascular
NCT04722250
Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
Emblok
NCT05295628
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
Cardiovascular Research Foundation, New York
NCT02661451
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
Edwards Lifesciences
NCT03517436
Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients
Catharina Ziekenhuis Eindhoven
NCT04514250
Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)
Main Line Health
NCT05541679
Early Feasibility Study for the Foldax Tria Aortic Heart Valve
Foldax
NCT03851068
Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform
Tempus AI
NCT06099665
Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes
Eko Devices
NCT04400513
Aortic Valve Replacement With Trifecta(TM)
Abbott Medical Devices
NCT00475709
Improving Echo Measurements in the Diagnosis of Aortic Stenosis
Baylor Research Institute
NCT02146755
Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access
National Heart, Lung, and Blood Institute (NHLBI)
NCT02280824
Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement
Brigham and Women's Hospital
NCT02805309
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
University of British Columbia
NCT04827238
Remote Ischemic Preconditioning for Renal Protection in TAVI
Henry Ford Health System
NCT03347032
Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement
WellSpan Health
NCT03107897
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Aortic Valve Stenosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Aortic Valve Stenosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Aortic Valve Stenosis page
31 registered trials, 13 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 13 Aortic Valve Stenosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Edwards Lifesciences sponsors the most Aortic Valve Stenosis trials on record, review their full trial history before evaluating a specific study. See Edwards Lifesciences's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Aortic Valve Stenosis condition card totals 31 registered trials; most-linked intervention Amplatzer Duct Occluder; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.