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Aortic Valve Stenosis
Open-data reference.
31 US clinical trials · 13 currently recruiting
Active & Recent Trials
STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)
The Society of Thoracic Surgeons
NCT01737528
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
Edwards Lifesciences
NCT04889872
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Semmelweis University
NCT07016477
Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
NCT05459233
Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial
Cedars-Sinai Medical Center
NCT06817148
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Edwards Lifesciences
NCT05172973
Effect of Fetal Aortic Valvuloplasty on Outcomes
Queen Silvia Children's Hospital, Gothenburg, Sweden
NCT05386173
CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation
University of Colorado, Denver
NCT07008911
Imaging Histone Deacetylase in the Heart
Massachusetts General Hospital
NCT03549559
MRI in Transcatheter Aortic Valve Replacement Patients
University Hospitals Cleveland Medical Center
NCT05603026
Platelet Adhesion in the Pathobiology of Aortic Stenosis
University of Virginia
NCT05550896
Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR
Baylor Research Institute
NCT05862558
Detecting Changes in Arterial Blood Volume and Cardiac Efficiency
HemoCept
NCT07205341
Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients
Medtronic Cardiovascular
NCT02701283
Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial
Abbott Medical Devices
NCT02000115
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
Medtronic Cardiovascular
NCT04722250
Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
Emblok
NCT05295628
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
Cardiovascular Research Foundation, New York
NCT02661451
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
Edwards Lifesciences
NCT03517436
Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients
Catharina Ziekenhuis Eindhoven
NCT04514250
Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)
Main Line Health
NCT05541679
Early Feasibility Study for the Foldax Tria Aortic Heart Valve
Foldax
NCT03851068
Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform
Tempus AI
NCT06099665
Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes
Eko Devices
NCT04400513
Aortic Valve Replacement With Trifecta(TM)
Abbott Medical Devices
NCT00475709
Improving Echo Measurements in the Diagnosis of Aortic Stenosis
Baylor Research Institute
NCT02146755
Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access
National Heart, Lung, and Blood Institute (NHLBI)
NCT02280824
Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement
Brigham and Women's Hospital
NCT02805309
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
University of British Columbia
NCT04827238
Remote Ischemic Preconditioning for Renal Protection in TAVI
Henry Ford Health System
NCT03347032
Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement
WellSpan Health
NCT03107897
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Aortic Valve Stenosis Trial Landscape
ClinicalTrials.gov lists 31 US studies indexed under Aortic Valve Stenosis, and 13 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Aortic Valve Stenosis shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Aortic Valve Stenosis is led by Edwards Lifesciences with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Aortic Valve Stenosis?
PlainTrial tracks 31 US clinical trials for Aortic Valve Stenosis, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Aortic Valve Stenosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.