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NCT02429557 · ClinicalTrials.gov registry record · Phase 1
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
A Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT02429557 is a Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 29 participants, below the 267-participant average among 30 other Multiple System Atrophy trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state.
The verdict
NCT02429557, a Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tolerance in these patients, and to compare them with those of the standard of care midodrine. The investigators will test the hypothesis that abdominal compression will blunt the exaggerated fall in stroke volume and the increase in abdominal vascular volume during head up tilt.
Conditions Studied
Interventions
- DRUG Placebo pill
- OTHER Abdominal compression
- OTHER Sham abdominal compression
- DRUG midodrine
Study Locations (1)
Tennessee
- Vanderbilt University - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2015-04 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02429557
The ClinicalTrials.gov registry entry for NCT02429557 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 267-participant average among 30 other Multiple System Atrophy trials with a reported enrollment target (89% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Multiple System Atrophy appearing as the primary indexed condition, and to 4 interventions - of which Placebo pill is the first listed.
NCT02429557 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT02429557 about?
NCT02429557 is a clinical study titled "Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure". Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tol...
What is the current status of trial NCT02429557?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2015-04. Estimated completion is 2026-12-31.
What conditions does trial NCT02429557 study?
This clinical trial studies the following conditions: Multiple System Atrophy, Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure.
What interventions are being tested in trial NCT02429557?
The interventions under investigation include: Placebo pill (DRUG), Abdominal compression (OTHER), Sham abdominal compression (OTHER), midodrine (DRUG).
Who is sponsoring clinical trial NCT02429557?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02429557 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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