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NCT02429557 · ClinicalTrials.gov registry record · Phase 1
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
A Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT02429557: Recruiting Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, sponsored by Vanderbilt University Medical Center.
NCT02429557 is a Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 29 participants, below the 267-participant average among 30 other Multiple System Atrophy trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02429557, a Phase 1 study of Multiple System Atrophy and Orthostatic Hypotension, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tolerance in these patients, and to compare them with those of the standard of care midodrine. The investigators will test the hypothesis that abdominal compression will blunt the exaggerated fall in stroke volume and the increase in abdominal vascular volume during head up tilt.
Primary Outcome
Percent change from supine in stroke volume during head up tilt
Conditions Studied
Interventions
- DRUG Placebo pill
- OTHER Abdominal compression
- OTHER Sham abdominal compression
- DRUG midodrine
Study Locations (1)
Tennessee
- Vanderbilt University - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2015-04 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
What NCT02429557 shows while recruiting
NCT02429557 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 267-participant average among 30 other Multiple System Atrophy trials with a reported enrollment target (89% lower).
The record links to 4 conditions, with Multiple System Atrophy appearing as the primary indexed condition, and to 4 interventions - of which Placebo pill is the first listed.
NCT02429557 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT02429557 about?
NCT02429557 is a clinical study titled "Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure". Compression garments have been shown to be effective in the treatment of orthostatic hypotension in autonomic failure patients. The purpose of this study is to determine the hemodynamic mechanisms by which abdominal compression (up to 40 mm Hg) improve the standing blood pressure and orthostatic tol...
What is the current status of trial NCT02429557?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2015-04. Estimated completion is 2026-12-31.
What conditions does trial NCT02429557 study?
This clinical trial studies the following conditions: Multiple System Atrophy, Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure.
What interventions are being tested in trial NCT02429557?
The interventions under investigation include: Placebo pill (DRUG), Abdominal compression (OTHER), Sham abdominal compression (OTHER), midodrine (DRUG).
Who is sponsoring clinical trial NCT02429557?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02429557 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple System Atrophy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02429557's enrollment target sits among peer trials
29 25th of 30 higher than 5 of 30 other Multiple System Atrophy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple System Atrophy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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