Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

NCT03556228 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, open-label, Phase 1/2 study of orally administered VMD-928 monotherapy and in combination with pembrolizumab in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curative therapy exists

Interventions

  • DRUG VMD-928 100 mg Tablet
  • DRUG VMD-928 Tablet and Pembrolizumab (200 mg)

Study Locations (15)

New Jersey

  • Englewood Hospital and Medical Center (site 202) — Englewood
  • Summit Medical Group (site 205) — Florham Park
  • Atlantic Health System, Morristown Medical Center (site 124) — Morristown

Florida

  • Holy Cross Hospital (site 213) — Fort Lauderdale
  • Memorial Cancer Institute at Memorial Healthcare Systems (site 132) — Pembroke Pines

California

  • Providence Medical Foundation (site 209) — Santa Rosa

Connecticut

  • Hartford Hospital (site 210) — Hartford

District of Columbia

  • The George Washington University Cancer Center (site 212) — Washington D.C.

New Mexico

  • Presbyterian Kaseman Hospital (site 208) — Albuquerque

New York

  • Weill Cornell Medicine, Cornell University (site 126) — New York

Ohio

  • Taylor Cancer Research Center (site 204) — Maumee

Trial Details

FieldValue
Enrollment Target 242 participants
Start Date 2018-06-08
Est. Completion 2028-06
Phase Phase 1

Sponsor

VM Oncology

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03556228

The ClinicalTrials.gov registry entry for NCT03556228 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 242 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VM Oncology, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which VMD-928 100 mg Tablet is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03556228 reports 15 study locations spanning 12 distinct geographic areas — top geographies include New Jersey, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03556228 about?

NCT03556228 is a clinical study titled "VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma". This is a multicenter, open-label, Phase 1/2 study of orally administered VMD-928 monotherapy and in combination with pembrolizumab in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curati...

What is the current status of trial NCT03556228?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 242 participants. The study started on 2018-06-08. Estimated completion is 2028-06.

What conditions does trial NCT03556228 study?

This clinical trial studies the following conditions: Lung Cancer, Pancreatic Cancer, Non-Small Cell Lung Cancer, Esophageal Cancer, Head and Neck Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03556228?

The interventions under investigation include: VMD-928 100 mg Tablet (DRUG), VMD-928 Tablet and Pembrolizumab (200 mg) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03556228?

This trial is sponsored by VM Oncology, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03556228 being conducted?

This trial has 15 study locations across California, Connecticut, District of Columbia, Florida, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial