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NCT00715611 · ClinicalTrials.gov registry record · Phase 2

Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma

A Phase 2 study of Mesothelioma, sponsored by Memorial Sloan Kettering Cancer Center.

Active
Registry status
Phase 2
Development phase
65
Enrollment target
12
Study locations

NCT00715611: Active Phase 2 study of Mesothelioma, sponsored by Memorial Sloan Kettering Cancer Center.

NCT00715611 is a Phase 2 study of Mesothelioma that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 65 participants, below the 197-participant average among 46 other Mesothelioma trials with a reported enrollment target (67% lower). The trial reports 12 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00715611, a Phase 2 study of Mesothelioma, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.

ACTIVE NOT RECRUITING
Registry status
Phase 2
Development phase
65 participants
Enrollment target
12
Study locations

Study Summary

For patients with this type of cancer, the standard of care is treatment with chemotherapy. Radiation therapy is typically not used. This is because radiation to the entire lining of the lung has many side effects that are often severe including damage to the lung (pneumonitis). There is a new radiation technique using Intensity Modulated Radiation Therapy (IMRT) that has been shown to reduce many of the side effects of standard radiation therapy. This type of radiation therapy specifically targets the lining of the lung, where you have your cancer, and reduces the risk of damaging the lung itself. The purpose of this study is to test the safety and implementation of standard pleurectomy/decortication (removal of the surface lining of the lung) and standard chemotherapy followed by IMRT performed at other centers. Patients will undergo pleurectomy/decortication chemotherapy and hemithoracic pleural IMRT to the pleura in patients with malignant pleural mesothelioma.

Conditions Studied

Mesothelioma

Interventions

  • RADIATION Intensity Modulated Radiation Therapy
  • PROCEDURE Pleurectomy/Decortication
  • DRUG pemetrexed and cisplatin or carboplatin

Study Locations (12)

New York

  • Memorial Sloan Kettering Cancer Center @ Suffolk-Commack - Commack
  • Memoral Sloan Kettering Westchester - Harrison
  • Memorial Sloan Kettering Cancer Center - New York
  • Memorial Sloan Kettering at Rockville Center, NY - Rockville Centre
  • Memorial Sloan Kettering Nassau - Uniondale

New Jersey

  • Memorial Sloan Kettering at Basking Ridge - Basking Ridge
  • Memorial Sloan Kettering Monmouth - Middletown
  • Memorial Sloan Kettering Bergen - Montvale

Florida

  • Moffitt Cancer Center - Tampa

Massachusetts

  • Brigham and Women's Hospital - Boston

Minnesota

  • Mayo Clinic Cancer Center - Rochester

Texas

  • Md Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 65 participants
Start Date 2008-10-11
Est. Completion 2026-07
Phase Phase 2

Sponsor

Memorial Sloan Kettering Cancer Center

1,884 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00715611

The ClinicalTrials.gov registry entry for NCT00715611 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 65 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 197-participant average among 46 other Mesothelioma trials with a reported enrollment target (67% lower). The listed sponsor is Memorial Sloan Kettering Cancer Center, which has 1,884 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Mesothelioma appearing as the primary indexed condition, and to 3 interventions - of which Intensity Modulated Radiation Therapy is the first listed.

NCT00715611 reports 12 study locations spanning 6 distinct geographic areas - top geographies include New York, New Jersey, Florida.

Frequently Asked Questions

What is clinical trial NCT00715611 about?

NCT00715611 is a clinical study titled "Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma". For patients with this type of cancer, the standard of care is treatment with chemotherapy. Radiation therapy is typically not used. This is because radiation to the entire lining of the lung has many side effects that are often severe including damage to the lung (pneumonitis). There is a new radia...

What is the current status of trial NCT00715611?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 65 participants. The study started on 2008-10-11. Estimated completion is 2026-07.

What conditions does trial NCT00715611 study?

This clinical trial studies the following conditions: Mesothelioma.

What interventions are being tested in trial NCT00715611?

The interventions under investigation include: Intensity Modulated Radiation Therapy (RADIATION), Pleurectomy/Decortication (PROCEDURE), pemetrexed and cisplatin or carboplatin (DRUG).

Who is sponsoring clinical trial NCT00715611?

This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00715611 being conducted?

This trial has 12 study locations across Florida, Massachusetts, Minnesota, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Read our methodology - how this data is sourced, computed, and verified.
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.