Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02414269 · ClinicalTrials.gov registry record · Phase 1
Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin
A Phase 1 study of Breast Cancer and Lung Cancer, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 113
- Enrollment target
- 6
- Study locations
NCT02414269: Active Phase 1 study of Breast Cancer and Lung Cancer, sponsored by Memorial Sloan Kettering Cancer Center.
NCT02414269 is a Phase 1 study of Breast Cancer and Lung Cancer that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 113 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (96% lower). The trial reports 6 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02414269, a Phase 1 study of Breast Cancer and Lung Cancer, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 113 participants
- Enrollment target
- 6
- Study locations
Study Summary
The purpose of this Phase I study is to test the safety of different doses of specially prepared immune cells (called "T cells") collected from blood. The Investigators want to find a safe dose of these modified T cells for patients who have malignant pleural disease. They want to find out what effects these T cells have on the patient and the cancer (MPD). Phase 2 part of the study, the investigators will test the dose in combination with another drug, pembrolizumab, to see what effects the study treatment has on malignant pleural mesothelioma.
Primary Outcome
All AEs and laboratory toxicities will be graded using version 4 of the CTCAE.
Conditions Studied
Interventions
- DRUG pembrolizumab
- DRUG cyclophosphamide
- GENETIC iCasp9M28z T cell infusions
Study Locations (6)
New Jersey
- Memorial Sloan Kettering Basking Ridge (Consent and Follow-Up) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Consent and Follow-Up) - Middletown
- Memorial Sloan Kettering Bergen (Consent and Follow-Up) - Montvale
New York
- Memorial Sloan Kettering Commack (Consent and Follow-Up) - Commack
- Memorial Sloan Kettering Westchester (Consent and Follow-Up) - Harrison
- Memorial Sloan Kettering Cancer Center (Consent and Follow-Up) - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2015-05 |
| Est. Completion | 2026-04-30 |
| Phase | Phase 1 |
What the registry record for NCT02414269 still lists
NCT02414269 is an interventional study that assigns participants to a tested intervention. The registered 113 participants enrollment target is mid-sized for trials with a published cap, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (96% lower).
The record links to 5 conditions, with Breast Cancer appearing as the primary indexed condition, and to 3 interventions - of which pembrolizumab is the first listed.
NCT02414269 lists 6 locations in 2 states (New Jersey, New York).
Frequently Asked Questions
What is clinical trial NCT02414269 about?
NCT02414269 is a clinical study titled "Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin". The purpose of this Phase I study is to test the safety of different doses of specially prepared immune cells (called "T cells") collected from blood. The Investigators want to find a safe dose of these modified T cells for patients who have malignant pleural disease. They want to find out what effe...
What is the current status of trial NCT02414269?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 113 participants. The study started on 2015-05. Estimated completion is 2026-04-30.
What conditions does trial NCT02414269 study?
This clinical trial studies the following conditions: Breast Cancer, Lung Cancer, Mesothelioma, Metastases, Malignant Pleural Disease.
What interventions are being tested in trial NCT02414269?
The interventions under investigation include: pembrolizumab (DRUG), cyclophosphamide (DRUG), iCasp9M28z T cell infusions (GENETIC).
Who is sponsoring clinical trial NCT02414269?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02414269 being conducted?
This trial has 6 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02414269's enrollment target sits among peer trials
113 531st of 1224 higher than 693 of 1,224 other Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
VS-6766+Abema+Fulv in Met HR+/HER- BC
RECRUITING · Phase 1
-
KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer
RECRUITING · Phase 1
-
Focused Ultrasound and Gemcitabine in Breast Cancer
RECRUITING · Phase 1
-
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
RECRUITING · Phase 1
-
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
RECRUITING · Phase 1
-
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00748254 · 113 participants
Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
- NCT04753190 · 113 participants · NA
Light Timing Study
- NCT05799248 · 113 participants · Phase 3
Role of rhPSMA-7.3 PET/CT Imaging in Men With High-Risk Prostate Cancer Following Conventional Imaging and Associated Changes in Medical Management
- NCT07449715 · 113 participants
Respiration From Pleth Validation
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia