Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04439370 · ClinicalTrials.gov registry record
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
A clinical trial of Hypertension and Blood Pressure, sponsored by University of Minnesota.
- Recruiting
- Registry status
- 160
- Enrollment target
- 1
- Study location
NCT04439370: Recruiting study of Hypertension and Blood Pressure, sponsored by University of Minnesota.
NCT04439370 is a study of Hypertension and Blood Pressure that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 160 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04439370, a study of Hypertension and Blood Pressure, is actively recruiting participants, sponsored by University of Minnesota.
- RECRUITING
- Registry status
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.
Primary Outcome
Muscle sympathetic nerve activity (MSNA) is a measurement of sympathetic activity. This is measured by two small needles are inserted behind or on the side of the knee, one needle is an acupuncture needle and one needle is a small recording microelectrode (same size as the acupuncture needle). Outcome will be reported in units of bursts per minute.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Microneurography to measure muscle sympathetic nerve activity (MSNA)
- DIAGNOSTIC_TEST Baroreflex sensitivity testing
- DIAGNOSTIC_TEST Sympathoexcitatory Maneuvers
- DIAGNOSTIC_TEST Blood tests
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2019-10-01 |
| Est. Completion | 2026-12-30 |
What NCT04439370 shows while recruiting
NCT04439370 is an observational study that tracks outcomes without assigning an intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (95% lower).
The record links to 4 conditions, with Hypertension appearing as the primary indexed condition, and to 4 interventions - of which Microneurography to measure muscle sympathetic nerve activity (MSNA) is the first listed.
NCT04439370 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT04439370 about?
NCT04439370 is a clinical study titled "Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women". This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in prem...
What is the current status of trial NCT04439370?
This trial is currently recruiting. The enrollment target is 160 participants. The study started on 2019-10-01. Estimated completion is 2026-12-30.
What conditions does trial NCT04439370 study?
This clinical trial studies the following conditions: Hypertension, Blood Pressure, Menopause, Menopause, Premature.
What interventions are being tested in trial NCT04439370?
The interventions under investigation include: Microneurography to measure muscle sympathetic nerve activity (MSNA) (DIAGNOSTIC_TEST), Baroreflex sensitivity testing (DIAGNOSTIC_TEST), Sympathoexcitatory Maneuvers (DIAGNOSTIC_TEST), Blood tests (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04439370?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04439370 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04439370's enrollment target sits among peer trials
160 238th of 470 higher than 228 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Ketone Ester And Salt (KEAS) in Older Adults
RECRUITING · NA
-
How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes
RECRUITING · NA
-
Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients
RECRUITING · NA
-
Comparing Healthcare Visit Recording and Open Notes to Improve Chronic iLlness Care Experience in Older Adults
RECRUITING · NA
-
Childhood-Onset Essential Hypertension Natural History Study
RECRUITING
-
Early Time-Restricted Eating in Older Adults With Hypertension
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00501826 · 160 participants · Phase 2
Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
- NCT00992901 · 160 participants · Early Phase 1
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
- NCT01515527 · 160 participants · Phase 2
Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)
- NCT02193841 · 160 participants · Phase 3
Simple Bone Cysts in Kids
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI