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NCT06480695 · ClinicalTrials.gov registry record · NA
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
A NA study of Menopause, sponsored by University of Virginia.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06480695 is a NA study of Menopause that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 40 participants, below the 9,393-participant average among 54 other Menopause trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06480695, a NA study of Menopause, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an intensity dependent manner. The effects of nitrate supplementation and exercise training over a longer training program remains unexplored. This investigation will examine the impact of exercise training intensity with and without inorganic nitrate supplementation, on CVD and fitness outcomes. Postmenopausal females will be tested for maximal oxygen uptake and lactate threshold before randomization to one of four groups: that inorganic nitrate-rich beetroot juice, or beetroot juice with nitrate extracted; and assigned to one-month of calorie matched high-intensity or moderate-intensity exercise training. Vascular function and fitness will be evaluated before and after training.
Conditions Studied
Interventions
- BEHAVIORAL Moderate Intensity Exercise
- DIETARY_SUPPLEMENT Nitrate-Rich Beetroot Juice
- BEHAVIORAL High Intensity Exercise
- DIETARY_SUPPLEMENT Nitrate-Depleted Placebo Beetroot Juice
Study Locations (1)
Virginia
- Student Health and Wellness Building - Department of Kinesiology - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-07-01 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06480695
The ClinicalTrials.gov registry entry for NCT06480695 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 9,393-participant average among 54 other Menopause trials with a reported enrollment target (100% lower). The listed sponsor is University of Virginia, which has 449 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Menopause appearing as the primary indexed condition, and to 4 interventions - of which Moderate Intensity Exercise is the first listed.
NCT06480695 reports 1 study location spanning 1 distinct geographic area - top geographies include Virginia.
Frequently Asked Questions
What is clinical trial NCT06480695 about?
NCT06480695 is a clinical study titled "Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females". Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD r...
What is the current status of trial NCT06480695?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-07-01. Estimated completion is 2026-12-31.
What conditions does trial NCT06480695 study?
This clinical trial studies the following conditions: Menopause.
What interventions are being tested in trial NCT06480695?
The interventions under investigation include: Moderate Intensity Exercise (BEHAVIORAL), Nitrate-Rich Beetroot Juice (DIETARY_SUPPLEMENT), High Intensity Exercise (BEHAVIORAL), Nitrate-Depleted Placebo Beetroot Juice (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06480695?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06480695 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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