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NCT06480695 · ClinicalTrials.gov registry record · NA
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
A NA study of Menopause, sponsored by University of Virginia.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06480695: Recruiting NA study of Menopause, sponsored by University of Virginia.
NCT06480695 is a NA study of Menopause that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 40 participants, below the 9,393-participant average among 54 other Menopause trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06480695, a NA study of Menopause, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an intensity dependent manner. The effects of nitrate supplementation and exercise training over a longer training program remains unexplored. This investigation will examine the impact of exercise training intensity with and without inorganic nitrate supplementation, on CVD and fitness outcomes. Postmenopausal females will be tested for maximal oxygen uptake and lactate threshold before randomization to one of four groups: that inorganic nitrate-rich beetroot juice, or beetroot juice with nitrate extracted; and assigned to one-month of calorie matched high-intensity or moderate-intensity exercise training. Vascular function and fitness will be evaluated before and after training.
Primary Outcome
Participants will be placed in a supine position with their left forearm slightly extended and supinated with legs straight. The arteries will be imaged using a high-resolution 7.5MHz linear array transducer at rest, during 5 minutes of forearm occlusion via cuff inflation, and continuously for 3 minutes post-occlusion; an EKG trigger will be used to capture images during end-diastole of the cardiac cycle.
Conditions Studied
Interventions
- BEHAVIORAL Moderate Intensity Exercise
- DIETARY_SUPPLEMENT Nitrate-Rich Beetroot Juice
- BEHAVIORAL High Intensity Exercise
- DIETARY_SUPPLEMENT Nitrate-Depleted Placebo Beetroot Juice
Study Locations (1)
Virginia
- Student Health and Wellness Building - Department of Kinesiology - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-07-01 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT06480695 shows while recruiting
NCT06480695 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 9,393-participant average among 54 other Menopause trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Menopause appearing as the primary indexed condition, and to 4 interventions - of which Moderate Intensity Exercise is the first listed.
NCT06480695 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT06480695 about?
NCT06480695 is a clinical study titled "Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females". Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD r...
What is the current status of trial NCT06480695?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-07-01. Estimated completion is 2026-12-31.
What conditions does trial NCT06480695 study?
This clinical trial studies the following conditions: Menopause.
What interventions are being tested in trial NCT06480695?
The interventions under investigation include: Moderate Intensity Exercise (BEHAVIORAL), Nitrate-Rich Beetroot Juice (DIETARY_SUPPLEMENT), High Intensity Exercise (BEHAVIORAL), Nitrate-Depleted Placebo Beetroot Juice (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06480695?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06480695 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Menopause
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06480695's enrollment target sits among peer trials
40 37th of 54 higher than 16 of 54 other Menopause trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Menopause trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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