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NCT01895959 · ClinicalTrials.gov registry record · Phase 4
To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
A Phase 4 study of Knee Osteoarthritis, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 4
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT01895959 is a Phase 4 study of Knee Osteoarthritis that has completed, run by University of California, San Francisco. The registered enrollment target is 12 participants, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01895959, a Phase 4 study of Knee Osteoarthritis, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to identify novel imaging markers for characterizing the biochemical profiles in synovial fluid and cartilage matrix in OA knee joints after intra-articular HA (Euflexxa) injection using high field NMR and MRI techniques. We hypothesize that: 1. High-field HRMAS NMR spectroscopy will provide sensitive measures for biochemical changes within knee synovial fluid after HA injection; 2. Baseline HRMAS spectroscopy, in particular N-acetyl peaks, as well as early changes of glutamate will predict patient response of pain relief after HA injection; 3. MR cartilage T1p and T2 quantifications will provide sensitive measures for biochemical changes within knee cartilage matrix after HA injection. Specifically cartilage T1p and T2 will decrease in patients who respond to the treatment, indicating potential beneficial effects of HA injection to cartilage preservation.
Conditions Studied
Interventions
- DEVICE Magnetic Resonance Imaging (MRI)
- DRUG Euflexxa
Study Locations (1)
California
- UCSF - China Basin Imaging Center - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2013-08 |
| Est. Completion | 2017-01 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01895959
The ClinicalTrials.gov registry entry for NCT01895959 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (96% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Knee Osteoarthritis appearing as the primary indexed condition, and to 2 interventions - of which Magnetic Resonance Imaging (MRI) is the first listed.
NCT01895959 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT01895959 about?
NCT01895959 is a clinical study titled "To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection". The purpose of this study is to identify novel imaging markers for characterizing the biochemical profiles in synovial fluid and cartilage matrix in OA knee joints after intra-articular HA (Euflexxa) injection using high field NMR and MRI techniques. We hypothesize that: 1. High-field HRMAS NMR sp...
What is the current status of trial NCT01895959?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 12 participants. The study started on 2013-08. Estimated completion is 2017-01.
What conditions does trial NCT01895959 study?
This clinical trial studies the following conditions: Knee Osteoarthritis.
What interventions are being tested in trial NCT01895959?
The interventions under investigation include: Magnetic Resonance Imaging (MRI) (DEVICE), Euflexxa (DRUG).
Who is sponsoring clinical trial NCT01895959?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01895959 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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