Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05160532 · ClinicalTrials.gov registry record · Phase 2
Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis
A Phase 2 study of Knee Osteoarthritis, sponsored by Mayo Clinic.
- Completed
- Registry status
- Phase 2
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT05160532: Completed Phase 2 study of Knee Osteoarthritis, sponsored by Mayo Clinic.
NCT05160532 is a Phase 2 study of Knee Osteoarthritis that has completed, run by Mayo Clinic. The registered enrollment target is 48 participants, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05160532, a Phase 2 study of Knee Osteoarthritis, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research is to learn more about treating Symptomatic Knee Osteoarthritis (OA) with an ultrasound-guided hypertonic dextrose injection. Researchers would like to determine best practice for injection frequency and effectiveness of the dextrose injection for symptomatic knee OA.
Primary Outcome
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) disease-specific tool used to measure physical function, pain, and stiffness in individuals with knee OA. Total scores range from 0-96, with higher scores indicating worse outcome.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Dextrose prolotherapy (DPT)
Study Locations (1)
Arizona
- Mayo Clinic in Arizona - Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2022-04-10 |
| Est. Completion | 2025-05-31 |
| Phase | Phase 2 |
What the finished NCT05160532 record still lists
NCT05160532 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Knee Osteoarthritis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05160532 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT05160532 about?
NCT05160532 is a clinical study titled "Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis". The purpose of this research is to learn more about treating Symptomatic Knee Osteoarthritis (OA) with an ultrasound-guided hypertonic dextrose injection. Researchers would like to determine best practice for injection frequency and effectiveness of the dextrose injection for symptomatic knee OA.
What is the current status of trial NCT05160532?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2022-04-10. Estimated completion is 2025-05-31.
What conditions does trial NCT05160532 study?
This clinical trial studies the following conditions: Knee Osteoarthritis.
What interventions are being tested in trial NCT05160532?
The interventions under investigation include: Placebo (DRUG), Dextrose prolotherapy (DPT) (DRUG).
Who is sponsoring clinical trial NCT05160532?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05160532 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Knee Osteoarthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05160532's enrollment target sits among peer trials
48 71st of 101 higher than 30 of 101 other Knee Osteoarthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Knee Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
RECRUITING · Phase 2
-
Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
RECRUITING · Phase 2
-
A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
RECRUITING · Phase 2
-
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
RECRUITING · Phase 2
-
A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
COMPLETED · Phase 2
-
Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee
COMPLETED · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01765777 · 48 participants · NA
Efficacy of Osteopathic Manipulative Medicine (OMM) and Phototherapy for Patients With Chronic Lower Back Pain
- NCT03073343 · 48 participants · NA
A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
- NCT03431064 · 48 participants
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
- NCT03514602 · 48 participants · NA
Maternal Smoking Cessation and Pediatric Obesity Prevention
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI