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ACTIVE NOT RECRUITING NA

Impact of Different Exercise Programs on Knee OA

NCT05844124 · View on ClinicalTrials.gov ↗

Study Summary

This study will examine and compare the changes in serum biomarkers, joint kinematics, and thigh muscle strength based on three different 8-week exercise protocols in individuals with knee pathology: Lower-body positive-pressure (LBPP) supported low-load treadmill walking and Aquatic exercise program and standard of care treadmill or community walking. Investigators hypothesize that both the 8-week exercise programs which aim to partially off-load the knee joint will be associated with a significant reduction in serum biological markers of joint disease (tissue turnover, cartilage degradation and inflammation) in response to the exercise. The serum biological markers will be directly correlated to participant reported knee pain. Both the LBPP-supported low-load and the aquatic exercise regimens will result in significant increases in thigh muscle strength about the degenerative knee which in-turn will result in diminished knee pain and enhanced joint function. Investigators aim to compare these two exercise programs to understand if benefits of one far exceeds the other as compared to standard of care treadmill or community walking.

Interventions

  • OTHER Exercise for Knee Osteoarthritis Recommendations (Control group)
  • OTHER Exercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking)
  • OTHER Exercise for Knee Osteoarthritis - (Aquatic Walking)

Study Locations (1)

Illinois

  • Shirley Ryan AbilityLab — Chicago

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2023-04-01
Est. Completion 2025-07-31
Phase NA

Sponsor

Shirley Ryan AbilityLab

274 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05844124

The ClinicalTrials.gov registry entry for NCT05844124 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Shirley Ryan AbilityLab, which has 274 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 6 conditions, with Osteoarthritis appearing as the primary indexed condition, and to 3 interventions — of which Exercise for Knee Osteoarthritis Recommendations (Control group) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05844124 reports 1 study location spanning 1 distinct geographic area — top geographies include Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05844124 about?

NCT05844124 is a clinical study titled "Impact of Different Exercise Programs on Knee OA". This study will examine and compare the changes in serum biomarkers, joint kinematics, and thigh muscle strength based on three different 8-week exercise protocols in individuals with knee pathology: Lower-body positive-pressure (LBPP) supported low-load treadmill walking and Aquatic exercise progra...

What is the current status of trial NCT05844124?

This trial is currently active not recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2023-04-01. Estimated completion is 2025-07-31.

What conditions does trial NCT05844124 study?

This clinical trial studies the following conditions: Osteoarthritis, Knee Osteoarthritis, Arthritis, Musculoskeletal Diseases, Rheumatic Diseases. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05844124?

The interventions under investigation include: Exercise for Knee Osteoarthritis Recommendations (Control group) (OTHER), Exercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking) (OTHER), Exercise for Knee Osteoarthritis - (Aquatic Walking) (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05844124?

This trial is sponsored by Shirley Ryan AbilityLab, which has 274 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05844124 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial