Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05003323 · ClinicalTrials.gov registry record
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
A clinical trial of Chronic Pain and Knee Osteoarthritis, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 110
- Enrollment target
- 1
- Study location
NCT05003323: Completed study of Chronic Pain and Knee Osteoarthritis, sponsored by University of Pittsburgh.
NCT05003323 is a study of Chronic Pain and Knee Osteoarthritis that has completed, run by University of Pittsburgh. The registered enrollment target is 110 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05003323, a study of Chronic Pain and Knee Osteoarthritis, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 110 participants
- Enrollment target
- 1
- Study location
Study Summary
This case-control study in patients with knee osteoarthritis and pain-free control individuals aims to develop a brain biomarker of endogenous analgesia that may be used in subsequent clinical trials. Deficits in central nervous system (CNS) pain inhibition may contribute to chronic pain intensity, but quantitative sensory testing (QST) methods are limited. Incorporating brain imaging to assessments of CNS pain inhibition, by examining activity in relevant brain networks, would allow for an objective, physiologic measure of CNS pain inhibition. Preliminary data in pain-free volunteers implicate cortical activity measured with functional near-infrared spectroscopy (fNIRS) during CNS pain inhibition. Broadly, the investigators hypothesize that variability in CNS pain inhibition contributes to variability in clinical pain intensity.
Primary Outcome
Pain intensity difference during offset and control heat stimuli
Conditions Studied
Study Locations (1)
Pennsylvania
- UPMC Pain Medicine at Centre Commons - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2021-11-18 |
| Est. Completion | 2023-10-20 |
What the finished NCT05003323 record still lists
NCT05003323 is an observational study that tracks outcomes without assigning an intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (86% lower).
The record links to 4 conditions, with Chronic Pain appearing as the primary indexed condition, and to 0 interventions.
NCT05003323 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05003323 about?
NCT05003323 is a clinical study titled "Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain". This case-control study in patients with knee osteoarthritis and pain-free control individuals aims to develop a brain biomarker of endogenous analgesia that may be used in subsequent clinical trials. Deficits in central nervous system (CNS) pain inhibition may contribute to chronic pain intensity, ...
What is the current status of trial NCT05003323?
This trial is currently completed. The enrollment target is 110 participants. The study started on 2021-11-18. Estimated completion is 2023-10-20.
What conditions does trial NCT05003323 study?
This clinical trial studies the following conditions: Chronic Pain, Knee Osteoarthritis, Analgesia, Chronic Knee Pain.
Who is sponsoring clinical trial NCT05003323?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05003323 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05003323's enrollment target sits among peer trials
110 128th of 301 higher than 172 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software
RECRUITING · NA
-
Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
RECRUITING · NA
-
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
RECRUITING · NA
-
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
RECRUITING · NA
-
Group-based Integrative Pain Management in Primary Care Safety Net Clinics
RECRUITING · NA
-
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01530373 · 110 participants · Phase 2
Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
- NCT02379377 · 110 participants · Phase 1
18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
- NCT02411773 · 110 participants · Phase 1
Sympatholysis in Chronic Kidney Disease
- NCT03190941 · 110 participants · Phase 1
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI