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NCT05003323 · ClinicalTrials.gov registry record
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
A clinical trial of Chronic Pain and Knee Osteoarthritis, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 110
- Enrollment target
- 1
- Study location
NCT05003323 is a study of Chronic Pain and Knee Osteoarthritis that has completed, run by University of Pittsburgh. The registered enrollment target is 110 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05003323, a study of Chronic Pain and Knee Osteoarthritis, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 110 participants
- Enrollment target
- 1
- Study location
Study Summary
This case-control study in patients with knee osteoarthritis and pain-free control individuals aims to develop a brain biomarker of endogenous analgesia that may be used in subsequent clinical trials. Deficits in central nervous system (CNS) pain inhibition may contribute to chronic pain intensity, but quantitative sensory testing (QST) methods are limited. Incorporating brain imaging to assessments of CNS pain inhibition, by examining activity in relevant brain networks, would allow for an objective, physiologic measure of CNS pain inhibition. Preliminary data in pain-free volunteers implicate cortical activity measured with functional near-infrared spectroscopy (fNIRS) during CNS pain inhibition. Broadly, the investigators hypothesize that variability in CNS pain inhibition contributes to variability in clinical pain intensity.
Conditions Studied
Study Locations (1)
Pennsylvania
- UPMC Pain Medicine at Centre Commons - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2021-11-18 |
| Est. Completion | 2023-10-20 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05003323
The ClinicalTrials.gov registry entry for NCT05003323 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 110 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (86% lower). The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Chronic Pain appearing as the primary indexed condition, and to 0 interventions.
NCT05003323 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05003323 about?
NCT05003323 is a clinical study titled "Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain". This case-control study in patients with knee osteoarthritis and pain-free control individuals aims to develop a brain biomarker of endogenous analgesia that may be used in subsequent clinical trials. Deficits in central nervous system (CNS) pain inhibition may contribute to chronic pain intensity, ...
What is the current status of trial NCT05003323?
This trial is currently completed. The enrollment target is 110 participants. The study started on 2021-11-18. Estimated completion is 2023-10-20.
What conditions does trial NCT05003323 study?
This clinical trial studies the following conditions: Chronic Pain, Knee Osteoarthritis, Analgesia, Chronic Knee Pain.
Who is sponsoring clinical trial NCT05003323?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05003323 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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