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Heart Failure With Preserved Ejection Fraction clinical trials
33 of 43 indexed Heart Failure With Preserved Ejection Fraction trials are currently recruiting.
43 US clinical trials · 33 currently recruiting
Heart Failure With Preserved Ejection Fraction is the subject of 43 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Northwestern University, running 3 of these trials.
The research picture
Heart Failure With Preserved Ejection Fraction has 43 registered US clinical trials, 33 of them open to new participants right now, about 77% of the total.
- 33
- recruiting participants now
- 77%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Northwestern University
Active & Recent Trials
43 total, page 1 of 1
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
Yale University
NCT04237701
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Amgen
NCT07037459
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
Uppsala University
NCT02901184
Assessment of CCM in HF With Higher Ejection Fraction
Impulse Dynamics
NCT05064709
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
Northwestern University
NCT05873634
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences
NCT05525663
Purinergic Signaling and the Postmenopausal Heart
Beth Israel Deaconess Medical Center
NCT06015776
Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
Mayo Clinic
NCT07401771
Study of JK07 in Patients With Chronic Heart Failure
Salubris Biotherapeutics
NCT06369298
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
Tectonic Therapeutic
NCT06616974
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Northwestern University
NCT06517186
Transitions of Care Clinic (TOCC)
Hackensack Meridian Health
NCT06937827
Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction
Medtronic Cardiac Rhythm and Heart Failure
NCT05839730
Home-Based Cardiac Rehabilitation for Patients With Heart Failure
Vanderbilt University Medical Center
NCT06479876
Ketogenic Diet vs Mixed Diet in Patients With Heart Failure
Ohio State University
NCT06081543
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
Indiana University
NCT06388226
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
VA Office of Research and Development
NCT06312748
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
University of Texas Southwestern Medical Center
NCT05723679
Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
The University of Texas Health Science Center at San Antonio
NCT05838287
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)
Massachusetts General Hospital
NCT04945707
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Northwestern University
NCT05719714
Physical Activity, Cardiac and Skeletal Muscle Energetics in Healthy Subjects and HFpEF Patients
Johns Hopkins University
NCT04998877
Matching Perfusion and Metabolic Activity in HFpEF
University of Pennsylvania
NCT04913805
SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
University of Pennsylvania
NCT05138575
The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF
University of Virginia
NCT05236413
A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
Mayo Clinic
NCT07083011
Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Michigan
NCT06337812
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
The University of Texas Health Science Center at San Antonio
NCT05057806
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
UConn Health
NCT05174351
A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
Mayo Clinic
NCT07093528
Pilot Study Lp299v Supplementation in Chronic Heart Failure
Medical College of Wisconsin
NCT05752760
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
Sardocor
NCT06061549
The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)
Heart Failure Solutions
NCT06702501
Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences
NCT05093959
Cardiac Rehab Effects in HFpEF
VA Office of Research and Development
NCT04506606
Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
University of Pittsburgh
NCT06576297
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
Massachusetts General Hospital
NCT06576050
Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Novartis
NCT06671314
Virtual Visits to Optimize Research Trial Offerings to HF Patients
The Cleveland Clinic
NCT04064541
Cilostazol for HFpEF
University of Minnesota
NCT05126836
Physiological Effects of Grape Seed Extract in Diastolic Heart Failure
University of Michigan
NCT01185067
Pressure Assessment to Improve Outcomes After TAVR: a Registry
North Florida Foundation for Research and Education
NCT03923530
Impact of Empagliflozin on Functional Capacity in Heart Failure with Preserved Ejection Fraction
University of Texas Southwestern Medical Center
NCT05139472
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 7 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Heart Failure With Preserved Ejection Fraction Trial Landscape
43 indexed Heart Failure With Preserved Ejection Fraction studies · 33 recruiting (77%).
Phase mix: 5 late (III/IV) vs 13 early (I/II).
Top sponsor: Northwestern University (3 trials), 9 others listed. 43 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Heart Failure With Preserved Ejection Fraction?
PlainTrial tracks 43 US clinical trials for Heart Failure With Preserved Ejection Fraction, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Failure With Preserved Ejection Fraction?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.