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Heart Failure With Preserved Ejection Fraction: early-phase trial registry
33 of 43 indexed Heart Failure With Preserved Ejection Fraction trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #339 of 28,707 conditions by registered trial count.
43 US clinical trials · 33 currently recruiting · #339 of 28,707 conditions by registered trial count
Heart Failure With Preserved Ejection Fraction: 43 US clinical trials tracked, 33 recruiting.
Heart Failure With Preserved Ejection Fraction is the subject of 43 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Northwestern University, running 3 of these trials.
Enrollment posture brief
Registry condition heart-failure-with-preserved-ejection-fraction
OPEN 33 | RECR 77% | LATE 5 | EARLY 13 | RANK #339 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Firearm Injury (77% recruiting · 13 trials)
Heart Failure With Preserved Ejection Fraction lists 33 open slots (77% of 43 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure With Preserved Ejection Fraction on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure With Preserved Ejection Fraction is recruiting above its size-band peers.
33 of 43 indexed trials (76.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure With Preserved Ejection Fraction trials is spread across many organizations.
Northwestern University accounts for 3 of 43 trials (7%). 32 distinct sponsors appear on at least one study for this condition label.
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Most Heart Failure With Preserved Ejection Fraction trials plan to enrol fewer than 100 people.
Median target enrolment is 78 among the 43 trials that report a genuine target (sentinel values excluded). 28 of those (65.1%) plan for fewer than 100 participants.
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Heart Failure With Preserved Ejection Fraction research is mostly interventional.
34 interventional and 9 observational studies make up this index (79.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
43 total, page 1 of 1
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
Yale University
NCT04237701
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Amgen
NCT07037459
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
Uppsala University
NCT02901184
Assessment of CCM in HF With Higher Ejection Fraction
Impulse Dynamics
NCT05064709
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
Northwestern University
NCT05873634
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences
NCT05525663
Purinergic Signaling and the Postmenopausal Heart
Beth Israel Deaconess Medical Center
NCT06015776
Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
Mayo Clinic
NCT07401771
Study of JK07 in Patients With Chronic Heart Failure
Salubris Biotherapeutics
NCT06369298
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
Tectonic Therapeutic
NCT06616974
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Northwestern University
NCT06517186
Transitions of Care Clinic (TOCC)
Hackensack Meridian Health
NCT06937827
Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction
Medtronic Cardiac Rhythm and Heart Failure
NCT05839730
Home-Based Cardiac Rehabilitation for Patients With Heart Failure
Vanderbilt University Medical Center
NCT06479876
Ketogenic Diet vs Mixed Diet in Patients With Heart Failure
Ohio State University
NCT06081543
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
Indiana University
NCT06388226
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
VA Office of Research and Development
NCT06312748
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
University of Texas Southwestern Medical Center
NCT05723679
Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
The University of Texas Health Science Center at San Antonio
NCT05838287
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)
Massachusetts General Hospital
NCT04945707
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Northwestern University
NCT05719714
Physical Activity, Cardiac and Skeletal Muscle Energetics in Healthy Subjects and HFpEF Patients
Johns Hopkins University
NCT04998877
Matching Perfusion and Metabolic Activity in HFpEF
University of Pennsylvania
NCT04913805
SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
University of Pennsylvania
NCT05138575
The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF
University of Virginia
NCT05236413
A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
Mayo Clinic
NCT07083011
Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Michigan
NCT06337812
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
The University of Texas Health Science Center at San Antonio
NCT05057806
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
UConn Health
NCT05174351
A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
Mayo Clinic
NCT07093528
Pilot Study Lp299v Supplementation in Chronic Heart Failure
Medical College of Wisconsin
NCT05752760
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
Sardocor
NCT06061549
The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)
Heart Failure Solutions
NCT06702501
Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences
NCT05093959
Cardiac Rehab Effects in HFpEF
VA Office of Research and Development
NCT04506606
Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
University of Pittsburgh
NCT06576297
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
Massachusetts General Hospital
NCT06576050
Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Novartis
NCT06671314
Virtual Visits to Optimize Research Trial Offerings to HF Patients
The Cleveland Clinic
NCT04064541
Cilostazol for HFpEF
University of Minnesota
NCT05126836
Physiological Effects of Grape Seed Extract in Diastolic Heart Failure
University of Michigan
NCT01185067
Pressure Assessment to Improve Outcomes After TAVR: a Registry
North Florida Foundation for Research and Education
NCT03923530
Impact of Empagliflozin on Functional Capacity in Heart Failure with Preserved Ejection Fraction
University of Texas Southwestern Medical Center
NCT05139472
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 7 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure With Preserved Ejection Fraction records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure With Preserved Ejection Fraction trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure With Preserved Ejection Fraction page
43 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Heart Failure With Preserved Ejection Fraction trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Northwestern University sponsors the most Heart Failure With Preserved Ejection Fraction trials on record, review their full trial history before evaluating a specific study. See Northwestern University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure With Preserved Ejection Fraction condition card totals 43 registered trials; most-linked intervention Placebo; top US site state Minnesota. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.