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NCT04913805 · ClinicalTrials.gov registry record · Phase 2

Matching Perfusion and Metabolic Activity in HFpEF

A Phase 2 study of Heart Failure With Preserved Ejection Fraction, sponsored by University of Pennsylvania.

Recruiting
Registry status
Phase 2
Development phase
53
Enrollment target
1
Study location

NCT04913805 is a Phase 2 study of Heart Failure With Preserved Ejection Fraction that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 53 participants, below the 2,287-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04913805, a Phase 2 study of Heart Failure With Preserved Ejection Fraction, is actively recruiting participants, sponsored by University of Pennsylvania.

RECRUITING
Registry status
Phase 2
Development phase
53 participants
Enrollment target
1
Study location

Study Summary

This study will test whether pharmacologic agents that increase perfusion \[Potassium Nitrate (KNO3)\], with and without additional supplements that may improve mitochondrial function \[Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).

Conditions Studied

Heart Failure With Preserved Ejection Fraction

Interventions

  • DRUG Potassium Nitrate
  • DRUG Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside
  • OTHER Potassium Chloride

Study Locations (1)

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 53 participants
Start Date 2021-10-11
Est. Completion 2027-05-01
Phase Phase 2

Sponsor

University of Pennsylvania

1,423 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04913805

The ClinicalTrials.gov registry entry for NCT04913805 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 53 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,287-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (98% lower). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Heart Failure With Preserved Ejection Fraction appearing as the primary indexed condition, and to 3 interventions - of which Potassium Nitrate is the first listed.

NCT04913805 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT04913805 about?

NCT04913805 is a clinical study titled "Matching Perfusion and Metabolic Activity in HFpEF". This study will test whether pharmacologic agents that increase perfusion \[Potassium Nitrate (KNO3)\], with and without additional supplements that may improve mitochondrial function \[Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)\], improve submaximal exercise endurance and skeletal m...

What is the current status of trial NCT04913805?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 53 participants. The study started on 2021-10-11. Estimated completion is 2027-05-01.

What conditions does trial NCT04913805 study?

This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction.

What interventions are being tested in trial NCT04913805?

The interventions under investigation include: Potassium Nitrate (DRUG), Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside (DRUG), Potassium Chloride (OTHER).

Who is sponsoring clinical trial NCT04913805?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04913805 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.