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NCT05839730 · ClinicalTrials.gov registry record · NA

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

A NA study of Heart Failure With Preserved Ejection Fraction and Concentric Hypertrophy, sponsored by Medtronic Cardiac Rhythm and Heart Failure.

Recruiting
Registry status
NA
Development phase
105
Enrollment target
9
Study locations

NCT05839730: Recruiting NA study of Heart Failure With Preserved Ejection Fraction and Concentric Hypertrophy, sponsored by Medtronic Cardiac Rhythm and Heart Failure.

NCT05839730 is a NA study of Heart Failure With Preserved Ejection Fraction and Concentric Hypertrophy that is actively recruiting participants, run by Medtronic Cardiac Rhythm and Heart Failure. The registered enrollment target is 105 participants, below the 2,286-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (95% lower). The trial reports 9 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05839730, a NA study of Heart Failure With Preserved Ejection Fraction and Concentric Hypertrophy, is actively recruiting participants, sponsored by Medtronic Cardiac Rhythm and Heart Failure.

RECRUITING
Registry status
NA
Development phase
105 participants
Enrollment target
9
Study locations

Study Summary

FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements in exercise capacity and health status of subjects.

Conditions Studied

Heart Failure With Preserved Ejection Fraction Concentric Hypertrophy

Interventions

  • DEVICE Pacemaker PLR + TRT ON
  • DEVICE Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest.

Study Locations (9)

Illinois

  • Prairie Education and Research Cooperative-St. Elizabeth's - O'Fallon
  • Prairie Education and Research Cooperative-St. John's - Springfield

Texas

  • Dallas VA Medical Center - Dallas
  • Houston Methodist Research Institute - Houston

Florida

  • NCH Heart Institute - Naples

Kansas

  • University of Kansas Medical Center - Kansas City

North Carolina

  • Duke University - Durham

Oklahoma

  • Oklahoma Heart Hospital - Oklahoma City

Vermont

  • The University of Vermont Medical Center - Burlington

Trial Details

FieldValue
Enrollment Target 105 participants
Start Date 2024-09-11
Est. Completion 2027-07
Phase NA
Medtronic Cardiac Rhythm and Heart Failure

115 total trials

What NCT05839730 shows while recruiting

NCT05839730 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, below the 2,286-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (95% lower).

The record links to 2 conditions, with Heart Failure With Preserved Ejection Fraction appearing as the primary indexed condition, and to 2 interventions - of which Pacemaker PLR + TRT ON is the first listed.

NCT05839730 lists 9 locations in 7 states (Illinois, Texas, Florida).

Frequently Asked Questions

What is clinical trial NCT05839730 about?

NCT05839730 is a clinical study titled "Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction". FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements ...

What is the current status of trial NCT05839730?

This trial is currently recruiting. It is a NA study. The enrollment target is 105 participants. The study started on 2024-09-11. Estimated completion is 2027-07.

What conditions does trial NCT05839730 study?

This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy.

What interventions are being tested in trial NCT05839730?

The interventions under investigation include: Pacemaker PLR + TRT ON (DEVICE), Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest. (DEVICE).

Who is sponsoring clinical trial NCT05839730?

This trial is sponsored by Medtronic Cardiac Rhythm and Heart Failure, which has 115 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05839730 being conducted?

This trial has 9 study locations across Florida, Illinois, Kansas, North Carolina, Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Heart Failure With Preserved Ejection Fraction

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05839730's enrollment target sits among peer trials

105 14th of 42 higher than 29 of 42 other Heart Failure With Preserved Ejection Fraction trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Heart Failure With Preserved Ejection Fraction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05839730

Source: ClinicalTrials.gov NCT05839730, the US trial registry maintained by the National Library of Medicine. NCT05839730 (mid enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.