Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction
NCT05839730 · View on ClinicalTrials.gov ↗
Study Summary
FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements in exercise capacity and health status of subjects.
Conditions Studied
Interventions
- DEVICE Pacemaker PLR + TRT ON
- DEVICE Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest.
Study Locations (9)
Illinois
- Prairie Education and Research Cooperative-St. Elizabeth's — O'Fallon
- Prairie Education and Research Cooperative-St. John's — Springfield
Texas
- Dallas VA Medical Center — Dallas
- Houston Methodist Research Institute — Houston
Florida
- NCH Heart Institute — Naples
Kansas
- University of Kansas Medical Center — Kansas City
North Carolina
- Duke University — Durham
Oklahoma
- Oklahoma Heart Hospital — Oklahoma City
Vermont
- The University of Vermont Medical Center — Burlington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2024-09-11 |
| Est. Completion | 2027-07 |
| Phase | NA |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05839730
The ClinicalTrials.gov registry entry for NCT05839730 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 105 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Medtronic Cardiac Rhythm and Heart Failure, which has 56 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Heart Failure With Preserved Ejection Fraction appearing as the primary indexed condition, and to 2 interventions — of which Pacemaker PLR + TRT ON is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05839730 reports 9 study locations spanning 7 distinct geographic areas — top geographies include Illinois, Texas, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05839730 about?
NCT05839730 is a clinical study titled "Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction". FIRE-HFpEF is a multi-center, prospective, randomized, single-blinded, clinical feasibility study. This study will enroll up to 105 subjects with heart failure with preserved ejection fraction in the United States. Data will be collected to evaluate whether pacing therapies can lead to improvements ...
What is the current status of trial NCT05839730?
This trial is currently recruiting. It is a NA study. The enrollment target is 105 participants. The study started on 2024-09-11. Estimated completion is 2027-07.
What conditions does trial NCT05839730 study?
This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05839730?
The interventions under investigation include: Pacemaker PLR + TRT ON (DEVICE), Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest. (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05839730?
This trial is sponsored by Medtronic Cardiac Rhythm and Heart Failure, which has 56 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05839730 being conducted?
This trial has 9 study locations across Florida, Illinois, Kansas, North Carolina, Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.