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NCT06015776 · ClinicalTrials.gov registry record
Purinergic Signaling and the Postmenopausal Heart
A clinical trial of Heart Failure With Preserved Ejection Fraction and Diastolic Heart Failure, sponsored by Beth Israel Deaconess Medical Center.
- Recruiting
- Registry status
- 500
- Enrollment target
- 1
- Study location
NCT06015776 is a study of Heart Failure With Preserved Ejection Fraction and Diastolic Heart Failure that is actively recruiting participants, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 500 participants, below the 2,276-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (78% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06015776, a study of Heart Failure With Preserved Ejection Fraction and Diastolic Heart Failure, is actively recruiting participants, sponsored by Beth Israel Deaconess Medical Center.
- RECRUITING
- Registry status
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
Conditions Studied
Interventions
- OTHER Gender
Study Locations (1)
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2019-07-01 |
| Est. Completion | 2030-06 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06015776
The ClinicalTrials.gov registry entry for NCT06015776 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 500 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,276-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (78% lower). The listed sponsor is Beth Israel Deaconess Medical Center, which has 488 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Heart Failure With Preserved Ejection Fraction appearing as the primary indexed condition, and to 1 intervention - of which Gender is the first listed.
NCT06015776 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06015776 about?
NCT06015776 is a clinical study titled "Purinergic Signaling and the Postmenopausal Heart". There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic r...
What is the current status of trial NCT06015776?
This trial is currently recruiting. The enrollment target is 500 participants. The study started on 2019-07-01. Estimated completion is 2030-06.
What conditions does trial NCT06015776 study?
This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction, Diastolic Heart Failure.
What interventions are being tested in trial NCT06015776?
The interventions under investigation include: Gender (OTHER).
Who is sponsoring clinical trial NCT06015776?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06015776 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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