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2026 data Public-data reference. official source

Aphasia

Open-data reference.

43 US clinical trials · 25 currently recruiting

Active & Recent Trials

RECRUITING 300 participants

ReadMap: Reading in Stroke Alexia and Typical Aging

Georgetown University

NCT06700005

RECRUITING NA 160 participants

Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia

University of Massachusetts, Amherst

NCT06990997

RECRUITING NA 135 participants

Language Processing and TMS

Medical College of Wisconsin

NCT05425615

RECRUITING NA 120 participants

tACS to Enhance Language Abilities

University of Pennsylvania

NCT06092814

RECRUITING Early Phase 1 120 participants

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

University of Texas at Austin

NCT06511752

RECRUITING NA 120 participants

Aphasia Physical EXercise Study: Randomized Trial

University of California, Berkeley

NCT07281313

RECRUITING NA 120 participants

Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke

Medical College of Wisconsin

NCT06048159

RECRUITING NA 104 participants

Sentence Production Training in Aphasia

Purdue University

NCT05415501

RECRUITING NA 100 participants

Telerehabilitation for Aphasia (TERRA)

University of South Carolina

NCT04682223

RECRUITING NA 100 participants

Neural Bases of Vocal Sensorimotor Impairment in Aphasia

The University of Texas at Dallas

NCT04742894

RECRUITING NA 90 participants

Neuroplasticity Biomarkers in Aphasia

University of Wisconsin, Madison

NCT06471127

RECRUITING Phase 2 88 participants

Escitalopram and Language Intervention for Subacute Aphasia

Johns Hopkins University

NCT03843463

RECRUITING NA 70 participants

Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits

Kessler Foundation

NCT06213272

RECRUITING NA 70 participants

Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine

Johns Hopkins University

NCT05845047

RECRUITING Phase 2 63 participants

Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

University of Pennsylvania

NCT06968663

RECRUITING NA 50 participants

Transcranial Alternating Current Stimulation (tACS) in Aphasia

Medical College of Wisconsin

NCT04375722

RECRUITING NA 50 participants

Treatment Outcomes With tDCS in Post-Stroke Aphasia

University of Arkansas

NCT03929432

RECRUITING NA 50 participants

Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.

University of New Mexi

NCT04432883

RECRUITING NA 50 participants

Post-Stroke Aphasia TMS

Medical College of Wisconsin

NCT06974279

RECRUITING NA 50 participants

Effect of Community Choir Singing in People With Chronic Post-stroke Aphasia

University of Ottawa

NCT06368323

RECRUITING Phase 2 40 participants

Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)

Teachers College, Columbia University

NCT07036406

RECRUITING Phase 2 32 participants

Adaptive Trial Scheduling in Naming Treatment for Aphasia

University of Pittsburgh

NCT05653466

RECRUITING NA 30 participants

Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia

City University of New York

NCT04142866

RECRUITING Phase 2 30 participants

Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia

University of Pittsburgh

NCT05653440

RECRUITING Phase 2 24 participants

Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

University of Pennsylvania

NCT06842745

ACTIVE NOT RECRUITING 400 participants

Brain-based Understanding of Individual Language Differences After Stroke

Georgetown University

NCT04991519

ACTIVE NOT RECRUITING NA 200 participants

HD-tDCS for Phonological Impairment in Aphasia

Medical College of Wisconsin

NCT06010030

ACTIVE NOT RECRUITING NA 120 participants

Genetic and Cognitive Predictors of Aphasia Treatment Response

Ohio State University

NCT05179538

ACTIVE NOT RECRUITING NA 60 participants

Treatment for Speech and Language in Primary Progressive Aphasia

University of Texas at Austin

NCT04881617

ACTIVE NOT RECRUITING NA 40 participants

Semantic Feature Analysis Treatment for Aphasia

VA Pittsburgh Healthcare System

NCT04215952

COMPLETED NA 110 participants

Word-Retrieval Treatment for Aphasia: Semantic Feature Analysis

US Department of Veterans Affairs

NCT00125242

COMPLETED Phase 2 86 participants

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia

H. Branch Coslett

NCT03651700

COMPLETED NA 63 participants

NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery

Dr. Alexander Thiel

NCT02020421

COMPLETED NA 56 participants

The Intensive Comprehensive Aphasia Program (ICAP)

Shirley Ryan AbilityLab

NCT03514186

COMPLETED 41 participants

TMS as a Biological Marker of Neuroplasticity

University of Pennsylvania

NCT02867670

COMPLETED NA 38 participants

Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia

Georgetown University

NCT01709383

COMPLETED NA 32 participants

Intention Treatment for Anomia

VA Office of Research and Development

NCT04267198

COMPLETED NA 28 participants

Exercise Effects on Word Learning

VA Office of Research and Development

NCT03370471

COMPLETED NA 23 participants

Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia

Penn State University

NCT03550092

COMPLETED NA 20 participants

Adapting Acceptance and Commitment Therapy for Stroke Survivors With Aphasia

University of Pittsburgh

NCT04984239

COMPLETED NA 12 participants

Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia

University of California, Berkeley

NCT06185023

COMPLETED NA 10 participants

Inner Speech and Naming Treatment for Individuals with Aphasia

George Washington University

NCT05980897

COMPLETED 1 participants

Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

Quality Living

NCT03662295

Phase Distribution

PhaseTrial count
Early Phase 1 1
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Aphasia Trial Landscape

ClinicalTrials.gov lists 43 US studies indexed under Aphasia, and 25 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Aphasia shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Aphasia is led by Medical College of Wisconsin with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 43 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Aphasia?

PlainTrial tracks 43 US clinical trials for Aphasia, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Aphasia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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