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Degenerative Disc Disease: full-pipeline trial registry
18 of 43 indexed Degenerative Disc Disease trials are currently recruiting.
Corpus placement: #339 of 28,707 conditions by registered trial count.
43 US clinical trials · 18 currently recruiting · #339 of 28,707 conditions by registered trial count
Degenerative Disc Disease: 43 US clinical trials tracked, 18 recruiting.
Degenerative Disc Disease is the subject of 43 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is NuVasive, running 4 of these trials.
Enrollment posture brief
Registry condition degenerative-disc-disease
OPEN 18 | RECR 42% | LATE 4 | EARLY 4 | RANK #339 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Sedentary Behavior (42% recruiting · 43 trials)
Degenerative Disc Disease lists 18 open slots (42% of 43 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Degenerative Disc Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Degenerative Disc Disease is recruiting above its size-band peers.
18 of 43 indexed trials (41.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Degenerative Disc Disease trials is spread across many organizations.
NuVasive accounts for 4 of 43 trials (9.3%). 34 distinct sponsors appear on at least one study for this condition label.
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Typical Degenerative Disc Disease enrolment sits around 100 participants.
Median target enrolment is 100 among the 43 trials that report a genuine target (sentinel values excluded). 21 of those (48.8%) plan for fewer than 100 participants.
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Degenerative Disc Disease splits between interventional and observational designs.
26 interventional and 17 observational studies make up this index (60.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
43 total, page 1 of 1
Personalized Spine Study Group (PSSG) Registry
University of Colorado, Denver
NCT04601363
Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease
VIVEX Biologics
NCT06778447
OssDsign® Spine Registry Study ("Propel")
OssDsign
NCT05329129
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
Mesoblast
NCT06325566
A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease
DiscGenics
NCT07254806
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
John O'Toole
NCT05029726
OssiMend BA in Posterolateral Instrumented Lumbar Fusion
Collagen Matrix
NCT04775537
MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion
Kuros Biosurgery
NCT05037968
Conduit Cages and Fibergraft BG Putty
Nitin Agarwal
NCT06704919
Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.
Highridge Medical
NCT06485206
Investigation of DEXA-C Anterior Cervical Interbody System
Aurora Spine and Pain
NCT05883436
Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion
Kuros Biosurgery
NCT04679844
ACDF Using Structural Allograft vs. Tritanium C
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT04388332
Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
Creative Medical Technology Holdings
NCT06053242
Trial for Treating Painful Degenerative Disc Disease
Regenexx
NCT05287867
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
Locate Bio Pty
NCT06462729
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
EicOsis Human Health
NCT06438471
Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty
University of California, Los Angeles
NCT05701059
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
CeraPedics
NCT03438747
Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD
Providence Medical Technology
NCT04229017
Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc
NuVasive
NCT05258435
Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages
Ohio State University
NCT05182489
Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels
Corewell Health East
NCT04214535
Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft.
Artoss
NCT04615260
VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs
VIVEX Biologics
NCT05201287
VIA Disc Nucleus Pulposus Older Patients Pilot
VIVEX Biologics
NCT05412277
Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)
Zimmer Biomet
NCT00726284
Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease
Aesculap Implant Systems
NCT00589797
CHARITE™ vs. ALIF 5-Year Follow-up
DePuy Spine
NCT00215332
PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries
Justin Parker Neurological Institute
NCT01406405
INFUSE® Bone Graft/ PEEK Interbody Spacer/ Anterior Cervical Plate Pivotal Clinical Trial
Medtronic Spinal and Biologics
NCT00485173
Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal Instability
Zimmer Biomet
NCT00726310
Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF)
Orthofix
NCT00951938
Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.
DePuy Spine
NCT00215319
Retrospective Modulus ALIF Study
NuVasive
NCT05566704
An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)
NuVasive
NCT01019057
Safety and Efficacy of the CarboClear Pedicle Screw System
CarboFix Orthopedics
NCT02626624
Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion
Induce Biologics USA
NCT05972616
Annex™ Adjacent Level System for Treatment of Adjacent Level Disease
Spine Wave
NCT02108249
Retrospective Multicenter Clinical Evaluation of Complications for Single or Multilevel VEO® Lateral Access and Interbody Fusion System and eXtreme Lateral Interbody Fusion (XLIF®) Subjects
Baxano Surgical
NCT01878149
Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion
RTI Surgical
NCT02628210
Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion
Mesoblast
NCT00996073
Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)
NuVasive
NCT00947583
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 3 | 3 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Degenerative Disc Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Degenerative Disc Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Degenerative Disc Disease page
43 registered trials, 18 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 18 Degenerative Disc Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- NuVasive sponsors the most Degenerative Disc Disease trials on record, review their full trial history before evaluating a specific study. See NuVasive's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Degenerative Disc Disease condition card totals 43 registered trials; most-linked intervention VIA Disc NP; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.