Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06081543 · ClinicalTrials.gov registry record · NA
Ketogenic Diet vs Mixed Diet in Patients With Heart Failure
A NA study of Heart Failure With Preserved Ejection Fraction, sponsored by Ohio State University.
- Recruiting
- Registry status
- NA
- Development phase
- 90
- Enrollment target
- 1
- Study location
NCT06081543: Recruiting NA study of Heart Failure With Preserved Ejection Fraction, sponsored by Ohio State University.
NCT06081543 is a NA study of Heart Failure With Preserved Ejection Fraction that is actively recruiting participants, run by Ohio State University. The registered enrollment target is 90 participants, below the 2,286-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06081543, a NA study of Heart Failure With Preserved Ejection Fraction, is actively recruiting participants, sponsored by Ohio State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is being done to evaluate the effects of a low carbohydrate ketogenic diet (KD) versus a low-fat diet (MD) on exercise tolerance in participants with heart failure with normal pumping function and diabetes or pre-diabetes, or metabolic syndrome, or obesity.
Primary Outcome
Participants will undergo VO2 max testing, conducted by trained professionals. VO2 max testing analyses will determine changes in maximal exercise performance
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Ketogenic diet
- DIETARY_SUPPLEMENT Low-fat Mixed diet
Study Locations (1)
Ohio
- The Ross Heart Hospital - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2023-05-19 |
| Est. Completion | 2026-08-31 |
| Phase | NA |
What NCT06081543 shows while recruiting
NCT06081543 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 2,286-participant average among 42 other Heart Failure With Preserved Ejection Fraction trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Heart Failure With Preserved Ejection Fraction appearing as the primary indexed condition, and to 2 interventions - of which Ketogenic diet is the first listed.
NCT06081543 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06081543 about?
NCT06081543 is a clinical study titled "Ketogenic Diet vs Mixed Diet in Patients With Heart Failure". This study is being done to evaluate the effects of a low carbohydrate ketogenic diet (KD) versus a low-fat diet (MD) on exercise tolerance in participants with heart failure with normal pumping function and diabetes or pre-diabetes, or metabolic syndrome, or obesity.
What is the current status of trial NCT06081543?
This trial is currently recruiting. It is a NA study. The enrollment target is 90 participants. The study started on 2023-05-19. Estimated completion is 2026-08-31.
What conditions does trial NCT06081543 study?
This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction.
What interventions are being tested in trial NCT06081543?
The interventions under investigation include: Ketogenic diet (DIETARY_SUPPLEMENT), Low-fat Mixed diet (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06081543?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06081543 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure With Preserved Ejection Fraction
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06081543's enrollment target sits among peer trials
90 17th of 42 higher than 24 of 42 other Heart Failure With Preserved Ejection Fraction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure With Preserved Ejection Fraction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
RECRUITING · NA
-
Pilot Study Lp299v Supplementation in Chronic Heart Failure
RECRUITING · NA
-
Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction
RECRUITING · NA
-
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
RECRUITING · NA
-
Transitions of Care Clinic (TOCC)
RECRUITING · NA
-
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02521311 · 90 participants · Phase 2
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)
- NCT02939573 · 90 participants · Phase 2
A Randomized Multicenter Study for Isolated Skin Vasculitis
- NCT03128879 · 90 participants · Phase 2
Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL
- NCT03184038 · 90 participants · NA
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI